Gene Expression Profiling of EGFR, FGFR2, PIK3CA, PTEN, SMAD4, STK11, and TP53 in Cell-Free RNA From Exhaled Breath Condensate: Diagnostic, Prognostic, and Therapeutic Implications in Advanced Lung Adenocarcinoma [0.03%]
EGFR、FGFR2、PIK3CA、PTEN、SMAD4、STK11和TP53在呼出气冷凝物中游离RNA的基因表达谱分析：对晚期肺腺癌诊断、预后和治疗的意义
Sabina Latifova,Uygar Genis,Haydar Soydaner Karakus et al.
Sabina Latifova et al.
Background: Advanced non-small cell lung cancer (NSCLC), particularly lung adenocarcinoma, remains a leading cause of cancer-related mortality. Although molecular profiling has improved disease stratification, most biomar...
Patients With Stage III PLCNEC Advocated for Radiotherapy Combined With Chemotherapy While With Stage IV Focus on Individualized Management: Evidence From SEER [0.03%]
III期和IV期肺神经内分泌癌患者的治疗现状及建议：基于SEER数据库的证据分析
Yuze Zhao,Guantong Liu,Haitao Li et al.
Yuze Zhao et al.
Background: PLCNEC is a rare and highly aggressive lung cancer with a poor prognosis. Multimodal therapy, primarily chemotherapy-based, is the standard for advanced PLCNEC, but the role of radiotherapy remains unclear. ...
Case Report: Synchronous Manifestations of Kaposi Sarcoma Herpesvirus-Associated Disorders [0.03%]
卡波西肉瘤病毒相关疾病同步表现案例报告
Kandice Roberts,Paula Valiño Ramos,Saurabh Jindal et al.
Kandice Roberts et al.
Background: Kaposi sarcoma herpes virus (KSHV) is associated with multiple clinical manifestations, including primary effusion lymphoma, an aggressive CD38+ B cell lymphoma with a plasmablastic phenotype. ...
MITF Gain-of-Function Mutation in Metastatic Prostate Cancer: A Rare Finding With Potential Therapeutic Significance [0.03%]
转移性前列腺癌中MITF功能获得性突变的罕见发现及其潜在治疗意义
Paul J Pecorin,Nyembezi Dhliwayo,Matthew Demetrious et al.
Paul J Pecorin et al.
Background: Prostate cancer is the most common non-cutaneous malignancy in men and remains a leading cause of cancer-related mortality, particularly in aggressive variants. These tumors are usually associated with alterat...
Assessing Delay Patterns in Diagnosis and Care Among Breast Cancer Patients in Ethiopia [0.03%]
评估埃塞俄比亚乳腺癌患者诊断和治疗延迟模式
Meklit Solomon Gebremariam,Segni Kejela,Yeabtsega Amlaku Asres et al.
Meklit Solomon Gebremariam et al.
Background: In Ethiopia, breast cancer patients often present with advanced-stage disease, leading to high mortality. This study aimed to quantify diagnostic and treatment intervals and identify their association with sta...
Multicenter Study
Cancer reports (Hoboken, N.J.). 2026 Jun;9(6):e70593. DOI:10.1002/cnr2.70593 2026
Genetic and Clinical Features in TP53-Mutated Patients With Myelodysplastic Neoplasms: A Retrospective Study Based on Next-Generation Sequencing Data [0.03%]
TP53突变骨髓增生异常肿瘤患者的临床和遗传特征：基于下一代测序数据的回顾性研究
Yanming Cheng,Lixia Liu,Yu Gao et al.
Yanming Cheng et al.
Background: The recent fifth edition of World Health Organization and International Consensus Classification in 2022 recognized TP53-mutated myelodysplastic neoplasms (MDS) as a distinct entity requiring multi-hit classif...
Methyltransferase-Like 14 Promotes the Angiogenesis of Hepatocellular Carcinoma via Targeting Vascular Endothelial Growth Factor A [0.03%]
甲基转移酶类似物14通过靶向血管内皮生长因子A促进肝细胞癌血管生成
Xinmiao Xiong,Chuanfang Shu,Ziqun Qu et al.
Xinmiao Xiong et al.
Background: N6-methyladenosine (m6A) modification is a pivotal epitranscriptomic regulator implicated in tumor progression. As a core component of the m6A methyltransferase complex, METTL14 is known to suppress tumorigene...
Adrenocortical Carcinoma in Peutz-Jeghers Syndrome With a Rare STK11 Pathogenic Germline Variant: A Case Report [0.03%]
Peutz-jeghers综合征伴发罕见的STK11致病性胚系变异的肾上腺皮质癌一例报告
Tomoki Ishida,Shuya Kandori,Reo Takahashi et al.
Tomoki Ishida et al.
Background: Peutz-Jeghers syndrome (PJS) is an inherited, autosomal-dominant condition, featuring STK11 germline mutations, characterized by hamartomatous gastrointestinal polyps and increased cancer risk. The most common...
Pharmacotherapeutic Management of Depression in Patients With Cancer: A Review of Mechanistic and Clinical Evidence [0.03%]
癌症患者抑郁的药理治疗：机制和临床证据综述
Sepideh Hajivalizadeh,Kimia Farahmand,Kimia Kazemzadeh et al.
Sepideh Hajivalizadeh et al.
Background: Depression is a prevalent comorbidity in cancer, yet conventional treatments show inconsistent efficacy. This review sought to provide a mechanism-based framework for managing cancer-related depression by expl...
Development of a Machine Learning Model for Distant Metastasis Risk Stratification in Acral Melanoma [0.03%]
用于肢端黑色素瘤远处转移风险分层的机器学习模型的研发
Ye Shanyuan,Zhang Rundong,Cao Meng et al.
Ye Shanyuan et al.
Background: Acral melanoma (AM) is a distinct melanoma subtype associated with delayed diagnosis, aggressive progression, and poor prognosis once distant metastasis occurs. However, prediction models specifically designed...