Regulator of telomere elongation helicase 1 gene and its association with malignancy [0.03%]
端粒延长解旋酶1基因与恶性肿瘤的关系研究
Mohammad Arian Hassani,Jamshid Murid,Jinsong Yan
Mohammad Arian Hassani
Background: With the progression of next-generation sequencing technologies, researchers have identified numerous variants of the regulator of telomere elongation helicase 1 (RTEL1) gene that are associated with a broad s...
Cooperative induction of receptor tyrosine kinases contributes to adaptive MAPK drug resistance in melanoma through the PI3K pathway [0.03%]
受体酪氨酸激酶的协同诱导通过PI3K途径促进黑色素瘤中MAPK药物抗性的适应性产生
Tine Norman Alver,Karen-Marie Heintz,Eivind Hovig et al.
Tine Norman Alver et al.
Vemurafenib-induced drug resistance in melanoma has been linked to receptor tyrosine kinase (RTK) upregulation. The MITF and SOX10 genes play roles as master regulators of melanocyte and melanoma development. Here, we aimed to explore the c...
Association of neighborhood-level social determinants of health with psychosocial distress in patients newly diagnosed with lung cancer [0.03%]
肺癌新发患者的社区水平社会健康决定因素与心理社会困扰的关系
Oluwabunmi M Emidio,Sarah L Cutrona,Sharina D Person et al.
Oluwabunmi M Emidio et al.
Background and aim: Patients with lung cancer experience high rates of psychosocial distress. They are also more likely to have unresolved, unmet social needs which may contribute to psychosocial distress. Despite this, n...
Synergetic effect of high dose rate radiations (10× FFF/2400 MU/min/10 MV x-rays) and paclitaxel selectively eliminates melanoma cells [0.03%]
高剂量率放疗（10×FFF/2400MU/min/10MV光子线）与紫杉醇协同特异杀伤黑色素瘤细胞
Niraj Lodhi,Poonam Nagpal,Sreeja Sarojini et al.
Niraj Lodhi et al.
Background: Melanoma is one of the most aggressive cancers, with 1.6% of total cancer deaths in the United States. In recent years treatment options for metastatic melanoma have been improved by the FDA approval of new th...
Two pediatric oncologic cases of hypereosinophilic syndrome and review of the literature [0.03%]
儿童高嗜酸性粒细胞综合征2例及文献复习
Julie Voeller,Thomas DeNapoli,Timothy C Griffin
Julie Voeller
Background: Persistent peripheral blood hypereosinophilia may cause tissue damage, leading to hypereosinophilic syndrome (HES) with end-organ dysfunction. Here we discuss two unique pediatric cases of primary hypereosinop...
Disparities in melanoma incidence and mortality in rural versus urban Michigan [0.03%]
美国密歇根州农村与城市地区黑色素瘤的发病率和死亡率差异
Richard A Shellenberger,Timothy M Johnson,Fatima Fayyaz et al.
Richard A Shellenberger et al.
Introduction: We sought to identifying the possible existence of disparities between rural and urban residents of Michigan for the incidence by stage of disease and disease-specific mortality for cutaneous melanoma (CM). ...
A case of HCC successfully treated with infliximab-steroid sequential therapy for small bowel perforation due to atezolizumab/bevacizumab combination therapy [0.03%]
阿特珠单抗/贝伐珠单抗联合治疗导致小肠穿孔采用英夫利昔诱导糖皮质激素序贯疗法成功救治1例肝细胞癌患者
Satoru Hagiwara,Yoriaki Komeda,Naoshi Nishida et al.
Satoru Hagiwara et al.
Background: Although reports of gastrointestinal perforation after immune-related adverse events (irAE) enteritis are rare, the anti- vascular endothelial growth factor (VEGF) effect of bevacizumab may be involved in gast...
Chronic postsurgical pain in children and young adults with cancer and choice of regional anesthesia for amputation and limb-sparing surgery [0.03%]
儿童及年轻人患癌的术后慢性疼痛以及截肢和保留肢体手术的区域麻醉选择
Doralina L Anghelescu,Emma Johns,Shalini Bhatia et al.
Doralina L Anghelescu et al.
Background: Patients undergoing limb amputation (LA) or limb-sparing (LS) for lower extremity oncologic diagnoses are at similar risk for chronic postsurgical pain of neuropathic nature (CPSP/NP). Regional anesthesia (RA)...
Determination of ERG(+), EZH2, NKX3.1, and SPINK-1 subtypes to evaluate their association with clonal origin and disease progression in multifocal prostate cancer [0.03%]
ERG（+）、EZH2、NKX3.1和SPINK-1亚型的测定及其与多灶性前列腺癌克隆起源和疾病进展的相关性评估
Yenifer Yamile Segura-Moreno,María Carolina Sanabria-Salas,Jorge Andrés Mesa-López De Mesa et al.
Yenifer Yamile Segura-Moreno et al.
Background: The prognostic relevance of prostate cancer (PCa) molecular subtypes remains controversial, given the presence of multiple foci with the possibility of different subtypes in the same patient. ...
Omicron variant of SARS-CoV-2, an epidemiologic assessment of pediatric oncology patients in the Bronx [0.03%]
奥密克戎变异株的流行病学评估——布朗克斯地区肿瘤儿童患者案例分析
Rachel Offenbacher,Joshua Gorlick,Daniel A Weiser
Rachel Offenbacher
Background: Children receiving cytotoxic therapy for cancer have increased risk of infection due to drug-induced neutropenia and are therefore treated empirically for bacteremia when febrile or ill-appearing. However, vir...