Too Old for Surgery? A Case Report of an Octogenarian Patient With Locally Advanced Lung Cancer Achieving Long-Term Survival via Bilobectomy Followed by Adjuvant Targeted Therapy [0.03%]
手术太老？一例八旬老年晚期肺癌患者行联合亚肺叶切除术，术后行辅助靶向治疗长期生存的病例报告
Han-Yu Deng,Jia-Hao Li,Xiao-Jun Tang et al.
Han-Yu Deng et al.
Background: An increasing number of octogenarian patients are being diagnosed with lung cancer, but they are less likely to receive surgery because of fragility. As a result, the optimal management of lung cancer in octog...
Targeting Spatiotemporal Heterogeneity of oncomiRNAs: A New Frontier in Cancer Therapy [0.03%]
针对致癌miRNA时空异质性的靶向治疗：癌症治疗的新前沿领域
T Jeethy Ram,Muralee Damodaran
T Jeethy Ram
Background: miRNAs are short RNA transcripts that modulate gene expression after transcription and have emerged as pivotal regulators of cancer biology. A subset, termed oncomiRNAs, functions as oncogenes or tumor suppres...
Human Epidermal Growth Factor Receptor 2-Positive, Claudin-18 Isoform 2-Positive, Mismatch Repair-Deficient Gastric Cancer Revealed by Immunohistochemical Analysis of Surgical Specimens: A Case Report [0.03%]
HER2阳性、Claudin-18.2阳性、错配修复缺陷型胃癌一例（附免疫组化病理图片）
Daichi Takagi,Mikito Mori,Kiyohiko Shuto et al.
Daichi Takagi et al.
Background: Human epidermal growth factor receptor 2 (HER2), mismatch repair (MMR) proteins, claudin-18 isoform 2 (CLDN18.2), and the programmed cell death ligand-1 combined positive score (PD-L1 CPS) are predictive bioma...
Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma [0.03%]
利用再定位药物增强替莫唑胺在胶质母细胞瘤中的疗效
Ali Nakhaei,Atefeh Taghavi,Amir R Afshari et al.
Ali Nakhaei et al.
Background: Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherap...
Oral Carcinoma Cuniculatum: Diagnostic Challenges and Emerging Perspectives-Case Report [0.03%]
舌乳头状癌的诊断挑战及新观点-病例报告
Toniya Raut,Neetu Jain,Shashi Keshwar et al.
Toniya Raut et al.
Background: Oral carcinoma cuniculatum (OCC) is a rare subtype of squamous cell carcinoma (SCC). It is characterized by a locally aggressive, burrowing lesion associated with an osteolytic defect yet lacks obvious cytolog...
Identification and Validation of Metabolic Hub Genes Using WGCNA and Prognostic Risk Modeling in Acute Myeloid Leukemia [0.03%]
急性髓系白血病中代谢中心基因的识别与验证及其预后模型构建研究
Samaneh Ramezani,Fatemeh Akhoundi,Reza Valadan et al.
Samaneh Ramezani et al.
Background: Acute myeloid leukemia (AML) is an aggressive and molecularly heterogeneous hematologic malignancy associated with poor clinical outcomes, particularly in elderly and high-risk patients. Increasing evidence su...
Improvement in Outcomes of Childhood Acute Myeloid Leukemia Treatment: A Survival Analysis at a Reference University Hospital in Rio de Janeiro, Brazil [0.03%]
巴西里约热内卢一所大学医院儿童急性髓系白血病治疗结局改善的生存分析
Thais Alcantara Bonilha,Deborah Sutter Ayres Pereira,Alice Maria Boulhosa de Azevedo et al.
Thais Alcantara Bonilha et al.
Background: Acute myeloid leukemia (AML) represents 15% to 20% of all pediatric acute leukemias and is responsible for nearly 30% of deaths in this population. While high-income countries report overall survival (OS) rate...
Factors Associated With Cervical Cancer Awareness Among Women of Reproductive Age in the Democratic Republic of the Congo: Evidence From a Nationwide DHS Analysis [0.03%]
基于全国DHS数据的刚果民主共和国育龄妇女宫颈癌知晓影响因素分析
Jovinary Adam,Olivier Mukuku,Stanislas Maseb&#x;a Mwang Sulu et al.
Jovinary Adam et al.
Background: Cervical cancer (CC) is a major public health concern, ranked as the fourth leading cause of cancer. Evidence shows that CC is preventable if detected and treated at the early stages. In the Democratic Republi...
Integrated Network Analysis Suggests an miR-21/MMP/VEGF-Associated Regulatory Axis in Gastric Cancer [0.03%]
整合网络分析发现胃癌中miR-21/MMP/VEGF相关调控轴
Fatemeh Babajani,Hadi Mozafari
Fatemeh Babajani
Background, aims: Gastric cancer (GC) pathogenesis involves complex molecular interactions that remain incompletely understood at a biological systems level. While microRNA-21 (miR-21), matrix metalloproteinases (MMPs), a...
Allwell A Ayirebi,Stephen Twumasi,Linda K Olaga et al.
Allwell A Ayirebi et al.
Background: The four primary subgroups of leukemia include chronic myeloid leukemia (CML), acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). Very little is known abo...