Expanding the phenotypic and genetic landscape of congenital neutropenia through whole-exome and genome sequencing [0.03%]
通过外显子组和基因组测序扩大先天性中性粒细胞减少症的表型和基因型谱系
Séverine Marti,Philippe Pellet,Blandine Beaupain et al.
Séverine Marti et al.
Congenital neutropenia (CN) comprises a heterogeneous group of rare genetic disorders. While some CN cases present only with neutropenia, others present with additional extra-hematological manifestations. The most common cause of CN is vari...
Development of myeloid neoplasia associated with prolonged immune cell-associated hematotoxicity after CAR T-cell treatment of B-cell lymphoma: Should we surveille for pre-existing myeloid mutations? [0.03%]
CAR-T细胞治疗B细胞淋巴瘤后与免疫细胞相关血液毒性的长期存在相关的髓系肿瘤的发生：是否应对既往存在的髓系基因突变进行监测？
Mattias Carlsten,Elisa Linnea Lindfors Rossi,Martin Jädersten et al.
Mattias Carlsten et al.
Andreas Verstraete,Quentin Van Thillo,Thomas Vanassche et al.
Andreas Verstraete et al.
Many patients suffer from venous thromboembolism (VTE) and its consequences. Despite substantial advancements with the introduction of direct oral anticoagulants (DOACs), patients and clinicians still encounter challenges in the acute and l...
Efficacy of erythroid-stimulating agent and luspatercept in VEXAS syndrome: A multicenter retrospective study by the FRENVEX group [0.03%]
VEXAS综合征铁剂和luspatercept疗效的多中心回顾性研究：FRENVEX工作组报告
Maël Heiblig,Vincent Jachiet,Jérôme Hadjadj et al.
Maël Heiblig et al.
Oncogenomic profiling in infant-toddler T-ALL identifies NKX2 family genes as drivers linked to favorable outcomes [0.03%]
婴儿和学步儿童T-急性淋巴细胞白血病的肿瘤基因组分析鉴定NKX2家族基因作为预后良好的驱动因子
Manon Delafoy,Estelle Balducci,Mathieu Simonin et al.
Manon Delafoy et al.
T-cell acute lymphoblastic leukemia (T-ALL) is a rare and aggressive hematological malignancy primarily affecting adolescents and young adults and is scarce in infants and toddlers under age 3. Unlike B-ALL, T-ALL in this young population r...
Characterization of cancer-associated fibroblasts and their spatial architecture reveals heterogeneity and survival associations in classic Hodgkin lymphoma [0.03%]
霍奇金淋巴瘤相关的成纤维细胞的特征及其空间结构显示了异质性和生存相关性
Suvi-Katri Leivonen,Kristiina Karihtala,Teijo Pellinen et al.
Suvi-Katri Leivonen et al.
Cancer-associated fibroblasts (CAFs) are a heterogeneous population of stromal cells, which modulate the immune system and can have both pro- and anti-tumorigenic effects. In classic Hodgkin lymphoma (cHL), the role of CAFs has remained lar...
Antigen selection reflected in the subclonal architecture of the B-cell receptor immunoglobulin gene repertoire in splenic marginal zone lymphoma [0.03%]
边缘区淋巴瘤中抗原选择反映在BCR免疫球蛋白基因文库的亚克隆结构中
Laura Zaragoza-Infante,Andreas Agathangelidis,Anastasia Iatrou et al.
Laura Zaragoza-Infante et al.
Almost one-third of all splenic marginal zone lymphoma (SMZL) cases express B-cell receptor immunoglobulin (BcR IG) encoded by the IGHV1-2*04 gene, implicating antigen selection in disease ontogeny. Evidence supporting this notion mostly de...
Genetic evolution and relapse-associated mutations in adult T-cell acute lymphoblastic leukemia patients treated in PETHEMA trials [0.03%]
成人T细胞急性淋巴细胞白血病患者在PETHEMA试验中的遗传进化和复发相关突变
Celia González-Gil,Thaysa Lopes,Mireia Morgades et al.
Celia González-Gil et al.
Relapse is the main cause of treatment failure in T-cell acute lymphoblastic leukemia (T-ALL). Despite this, data from adult T-ALL patients treated with specific chemotherapeutic regimens that examine predictive markers and describe relapse...
Applications of machine learning for immunophenotypic measurable residual disease assessment in acute myeloid leukemia [0.03%]
机器学习在急性髓系白血病免疫表型可测量残留疾病评估中的应用
Tim R Mocking,Arjan A van de Loosdrecht,Jacqueline Cloos et al.
Tim R Mocking et al.
Immunophenotypic detection and quantification of residual leukemic cells by multiparameter flow cytometry is increasingly adopted in the clinical practice of acute myeloid leukemia (AML) to assess measurable residual disease (MRD). However,...
Efficacy and safety of CAR T-cell therapy in patients with primary or secondary CNS lymphoma: A study on behalf of the EBMT and the GoCART coalition [0.03%]
CAR-T细胞治疗原发或继发中枢神经系统淋巴瘤患者的有效性和安全性：EBMT和GoCART联盟的研究
Anna Ossami Saidy,Christophe Peczynski,Catherine Thieblemont et al.
Anna Ossami Saidy et al.
Patients with relapsed or refractory (r/r) primary central nervous system (CNS) lymphoma (PCNSL) or secondary central nervous system (CNS) lymphoma (SCNSL) face a dismal prognosis. They have been excluded from most clinical CAR T-cell trial...