High-risk features of early relapse in newly-diagnosed multiple myeloma: The impact of cytogenetics and response to initial therapy [0.03%]
新诊断的多发性骨髓瘤早期复发的高危因素：细胞遗传学和初始治疗反应的影响
Andrea Manubens,Bruno Paiva,Norma C Gutiérrez et al.
Andrea Manubens et al.
Patients with newly-diagnosed multiple myeloma (MM) who experience early relapse (ER) have dismal overall survival (OS). Their prospective identification, either before or soon after treatment initiation, is paramount to use alternative app...
Comparing functional and genomic-based precision medicine in blood cancer patients [0.03%]
基于功能和基因组的精确医学在血液病患者中的比较研究
Lukas Kazianka,Alexander Pichler,Christiane Agreiter et al.
Lukas Kazianka et al.
Tumor-agnostic precision medicine (PM) strategies promise to support treatment decisions in relapsed/refractory blood cancer patients. Genomic-based PM (gPM) and drug screening-based functional PM (fPM) currently represent the most prominen...
Cumulative review of cardiac failure with acalabrutinib in the treatment of chronic lymphocytic leukemia using data from clinical trials and postmarketing experience [0.03%]
伊布替尼治疗慢性淋巴细胞白血病导致心力衰竭的累积评估:临床试验和上市后经验数据
Paolo Ghia,Naghmana Bajwa,Anthony J Corry et al.
Paolo Ghia et al.
Orchestration of human multi-lineage hematopoietic cell development by humanized in vivo bone marrow models [0.03%]
人类骨髓模型的人类多谱系造血细胞发育的交响乐式调控
Laurent Renou,Wenjie Sun,Chloe Friedrich et al.
Laurent Renou et al.
Hematopoiesis develops in the bone marrow (BM) where multiple interactions regulate the differentiation and preservation of hematopoietic stem and progenitor cells (HSPCs). Immune-deficient murine models have enabled the analysis of molecul...
Phosphatidic acid phosphatase LPIN1 in phospholipid metabolism and stemness in hematopoiesis and AML [0.03%]
磷脂代谢和造血及急性髓系白血病干细胞状态中的磷脂酸磷酸酶LPIN1的作用
Karin Huber,Swati Garg,Lena Schlautmann et al.
Karin Huber et al.
Targeting metabolism represents a promising approach to eradicate leukemic stem cells (LSCs) that are considered critical drivers of relapse in acute myeloid leukemia (AML). In this study, we demonstrate that the phosphatidic acid phosphata...
Spironolactone inhibits the NLRP1 inflammasome and alleviates defective erythropoiesis in Diamond-Blackfan anemia [0.03%]
螺内酯通过抑制NLRP1炎性小体改善Diamond-Blackfan贫血患者的无效红细胞生成
Lola Rodríguez-Ruiz,Juan M Lozano-Gil,María Ocaña-Esparza et al.
Lola Rodríguez-Ruiz et al.
A German multicenter real-world analysis of talquetamab in 138 patients with relapsed/refractory multiple myeloma [0.03%]
一项德国多中心真实世界研究： Talquetamab治疗复发/难治性多发性骨髓瘤患者的分析（138例患者）
Jan H Frenking,Christine Riedhammer,Raphael Teipel et al.
Jan H Frenking et al.
Bispecific T-cell engagers (BTCEs) represent a paradigm shift in the treatment of relapsed/refractory multiple myeloma (RRMM). Talquetamab, a GPRC5DxCD3 BTCE, has shown promising results in the MonumenTAL-1 trial and was recently approved b...
Patient-derived xenografts: Practical considerations for preclinical drug testing [0.03%]
基于患者的异种移植体：药物检测的实用性考虑因素（实验前）
Charles E de Bock
Charles E de Bock
European guidelines on treatment and supportive measures in chronic neutropenias: A consensus between the European Hematology Association and the EuNet-INNOCHRON COST Action based on a systematic evidence review [0.03%]
欧洲关于慢性中性粒细胞减少症治疗和支持措施的指南：欧洲血液学协会和EuNet-INNOCHRON COST行动根据系统证据审查达成共识
Francesca Fioredda,Michail Spanoudakis,Julia Skokowa et al.
Francesca Fioredda et al.
The treatment of chronic neutropenias and control of neutropenia-related infections remain challenging topics for pediatric and adult hematologists. This article aims to fill the gap in the treatment of neutropenias and, in combination with...
Caplacizumab treatment in elderly patients with iTTP: Experience from the Spanish TTP Registry [0.03%]
克拉克拉珠单抗治疗免疫性血栓性血小板减少性紫癜的西班牙注册研究中的老年患者经验
Inés Gómez-Seguí,Joan Cid,Miquel Lozano et al.
Inés Gómez-Seguí et al.
Immune thrombotic thrombocytopenic purpura (iTTP) typically affects middle-aged individuals, although it sometimes appears in older patients. Caplacizumab is approved for the treatment of iTTP, but information on the safety and efficacy of ...