Porphyria cutanea tarda associated with elevated serum ferritin, iron overload, and a bone morphogenetic protein 6 genetic variant [0.03%]
与血清纤溶原水平升高、铁负荷过量及骨形态发生蛋白6基因变异相关的迟发性皮肤卟啉病
Paul C Adams,Carolyn Horgan-Bell,Scott Walsh et al.
Paul C Adams et al.
A man aged 51 years was referred to dermatology for hand dermatitis. The dorsal hands and fingers had superficial erosions with pale pink shallow scars and milia suggestive of porphyria cutanea tarda (PCT). Urine and fecal studies were typi...
Evan D Elias,Julia Uhanova,Gerald Y Minuk
Evan D Elias
Background: Recent data suggest intestinal immunity including immunoglobulin A (IgA) may contribute to the pathogenesis of alcohol-induced liver disease (ALD). ...
Eric M Yoshida,Natasha Chandok
Eric M Yoshida
Mia J Biondi,Jordan J Feld
Mia J Biondi
Hepatitis C direct-acting antivirals (DAAs) have an efficacy of 95% or greater, with pangenotypic options. Many regions in Canada have recently abolished the need to demonstrate fibrosis before treatment with DAAs, and several combination t...
Iron overload and cirrhosis in referred HFE p.C282Y homozygotes with normal transferrin saturation and elevated serum ferritin [0.03%]
转铁蛋白饱和度正常但血清铁蛋白升高患者的赫费小体病(p.C282Y同合子)铁负荷过高和肝硬化状况
Paul C Adams,James C Barton
Paul C Adams
Background: levated transferrin saturation (TS) is an imperfect test to identify adults with high-iron gene (HFE) p.C282Y homozygosity or elevated hepatic iron concentration. ...
Serial liver transaminases have no prognostic value in non-alcoholic fatty liver disease [0.03%]
非酒精性脂肪肝病中连续肝转氨酶检测没有预后价值
Julia Uhanova,Gerald Minuk,Kamila Premji et al.
Julia Uhanova et al.
Background: Routine measurement of liver transaminases is common in the general monitoring of patients with non-alcoholic fatty liver disease (NAFLD), but there is little data to support the utility of this practice. The ...
B-type peptides to predict post-liver transplant mortality: systematic review and meta-analysis [0.03%]
B型利钠肽预测肝移植术后死亡率的系统评价和meta分析
Daljeet Chahal,Alan Yau,Paola Casciato et al.
Daljeet Chahal et al.
Background: Cirrhotic patients undergoing liver transplantation are at risk of cardiac complications. Brain natriuretic peptide (BNP) and amino terminal brain natriuretic peptide (NT-BNP) are used in cardiac risk stratifi...
Self-reported experiences of patients living with primary biliary cholangitis (PBC): Are we treating the liver but not the patient? [0.03%]
原发性胆汁性肝炎(PBC)患者的自我报告经历：我们在治疗肝脏，但忽略了患者本身吗？
Kathleen P Ismond,Bishoi Aziz,Gail M Wright et al.
Kathleen P Ismond et al.
Alternative medicine products causing acute liver injury: Pandora's box is open [0.03%]
替代医药产品导致急性肝损伤：潘多拉盒子已经打开
Fanny Bergeron,Trana Hussaini,Natasha Chandok et al.
Fanny Bergeron et al.
The regulatory loopholes governing alternative medicine products in Canada represent a public safety issue. In 2017 and 2018, the Liver Transplant Program of the University of British Columbia assessed three patients with acute liver failur...
Circulating and inducible IL-32α in chronic hepatitis C virus infection [0.03%]
慢性丙型肝炎病毒感染患者外周血及肝脏中IL-32α的表达分布研究
Mark Collister,Julia Rempel,Jiaqi Yang et al.
Mark Collister et al.
Background: Interleukin 32 (IL-32) is a recently described pro-inflammatory cytokine implicated in chronic hepatitis C virus (HCV)-related inflammation and fibrosis. IL-32α is the most abundant IL-32 isoform. ...