COVID-19 infection immediately post-transplant in an unvaccinated patient: Clinical observations and ethical implications [0.03%]
移植手术后未接种疫苗患者立即感染 COVID-19：临床观察和道德影响
Ben Cox,Trana Hussani,Vladimir Marquez et al.
Ben Cox et al.
We report the case of a 28-year-old woman who presented with acute liver failure from suspected drug-induced liver injury. She was not vaccinated against COVID-19 and expressed considerable reluctance to become vaccinated, prompting discuss...
Impacts of the COVID-19 pandemic on hepatitis C elimination in Canada: Where do we go from here? [0.03%]
COVID-19大流行对加拿大丙型肝炎消除的影响：我们下一步往哪里去？
Jawairia Atif,Sasha Tejna Persaud Udhesister,Mohamed N Abdelnabi et al.
Jawairia Atif et al.
Real-world treatment patterns, clinical outcomes, and health care resource utilization in advanced unresectable hepatocellular carcinoma [0.03%]
晚期不可切除肝细胞癌的真实世界治疗模式、临床结局和医疗资源利用情况
Dylan E O&#x;Sullivan,Devon J Boyne,Iqra A Syed et al.
Dylan E O&#x;Sullivan et al.
BACKGROUND: The incidence of advanced unresectable hepatocellular carcinoma (HCC) is increasing in developed countries and the prognosis of advanced HCC remains poor. Real-world evidence of treatment patterns and outcomes can highlight the ...
Natasha Chandok,Eric M Yoshida
Natasha Chandok
Unconjugated hyperbilirubinemia may exacerbate certain underlying chronic liver diseases [0.03%]
非结合性高胆红素血症可能会加重某些潜在的慢性肝病
Roman Dascal,Julia Uhanova,Gerald Y Minuk
Roman Dascal
BACKGROUND: Negative correlations have been described between elevated serum unconjugated bilirubin levels and the prevalence/severity of various chronic inflammatory conditions. Whether a similar association exists for patients with unconj...
Post-transplant diabetes mellitus in Canadian liver and renal transplant recipients [0.03%]
加拿大肝肾移植受者的移植后糖尿病
Roman Dascal,Chris Wiebe,Mina Niazi et al.
Roman Dascal et al.
BACKGROUND: Post-transplant diabetes mellitus (PTDM) occurs in 10%-40% of liver and renal transplant recipients. Whether the risk factors for PTDM in liver and renal transplant recipients are similar and whether Indigenous Canadians, who ha...
Educational interventions to improve hepatitis C testing or treatment in South Asian communities: A systematic review [0.03%]
改善南亚社区丙型肝炎检测或治疗的教育干预措施：系统评价
Muhammad Uzair Khalid,Shawn Khan,Daniel Koerber et al.
Muhammad Uzair Khalid et al.
BACKGROUND: Hepatitis C (HCV) places a disproportionately higher burden on the South Asian community in comparison to the general population, despite the availability of effective antiviral therapies. This study seeks to characterize the ef...
Real-world tertiary referral centre experience stopping nucleos(t)ide analogue therapy in patients with chronic hepatitis B [0.03%]
真实世界中在慢性乙型肝炎患者中停止核苷(酸)类似物治疗的三级转诊中心经验
Hassan Azhari,Alexandra D Frolkis,Abdel Aziz Shaheen et al.
Hassan Azhari et al.
BACKGROUND: Identifying strategies for stopping nucleos(t)ide analogues (NUC) in patients with chronic hepatitis B (CHB) is a major goal in CHB management. Our study describes our tertiary-centre experience stopping nucleos(t)ide analogues ...
A real-world retrospective single-centre study of the cost-effectiveness and long-term outcomes of pegylated interferon for chronic hepatitis B [0.03%]
一项关于聚乙二醇干扰素治疗慢性乙肝的回顾性单中心成本效益及长期结局研究
Stephen E Congly,Ahsan Syed,Sarah Haylock-Jacobs et al.
Stephen E Congly et al.
Background: Pegylated interferon (Peg-IFN) is recommended as first-line therapy for chronic hepatitis B (CHB) but has significant side effects and is rarely used compared to oral nucleos(t)ide analogues (NA). There are li...
Carolina Fernandes da Silva,Alexa Keeshan,Curtis Cooper
Carolina Fernandes da Silva
Hepatitis B virus (HBV) is a hepatotropic virus that affects approximately 296 million people worldwide. A crucial step to HBV replication is the transcription of its infectious DNA from its viral RNA intermediate. The production of the RNA...