Switching patients with inflammatory arthritis from Etanercept (Enbrel®) to the biosimilar drug, SB4 (Benepali®): A single-centre retrospective observational study in the UK and a review of the literature [0.03%]
从Etanercept（恩利）切换到SB4（益赛普）治疗炎性关节病患者的单中心回顾性观察研究及文献综述
Anastasia-Vasiliki Madenidou,Andrew Jeffries,Sneha Varughese et al.
Anastasia-Vasiliki Madenidou et al.
Objective/aim: SB4 (Benepali®), the Etanercept biosimilar, is licenced in the UK for the same indications as the reference product, Enbrel®. In 2016, the Rheumatology Department at Blackpool Teaching Hospitals switched ...
The role of the Nocebo effect in the use of biosimilars in routine rheumatology clinical practice [0.03%]
诺西蓓效应在生物类似药常规风湿病临床实践中的作用
Evrydiki Kravvariti,George D Kitas,Petros P Sfikakis
Evrydiki Kravvariti
SB4 in the Era of Biosimilars: Clinical Data and Real-World Experience [0.03%]
贝伐珠单抗生物类似药的时代：临床数据和真实世界经验
Shing T Law,Peter C Taylor
Shing T Law
A biosimilar is a biological medicinal product that is highly similar to an already authorized original biological medicinal product. The introduction of biosimilars may allow for a reduction in health care costs, due to discount pricing. C...
From Basic Immunology to Clinical Practice: Bio-Originators versus Bio-Similars [0.03%]
从基础免疫学到临床实践：生物原研药与生物类似药
Stamatis-Nick C Liossis,Georgia M Konstantopoulou
Stamatis-Nick C Liossis
Biologic agents are macromolecules, and as such, they have a high level of structural heterogeneity. Treatment with such agents has been extremely expensive limiting thus their availability to increasing numbers of patients; therefore, many...
Implementation of Physical Activity into routine Clinical pracTice in Rheumatic Musculoskeletal Disease: The IMPACT-RMD study protocol and rationale [0.03%]
在风湿性肌肉骨骼疾病临床实践中实施身体活动的实现-IMPACT-RMD研究方案与原理
George S Metsios,Sally Am Fenton,Helene Rikke Moe et al.
George S Metsios et al.
Background: Physical activity is an important intervention for improving disease-related symptoms and systemic manifestations in rheumatic and musculoskeletal disease (RMDs). However, studies suggest that RMD patients rep...
Mohammed B Alanazi,Yahya O Asiri,Ibrahim A Al-Homood
Mohammed B Alanazi
We describe a case of Immunoglobulin G4-related disease (IgG4-RD) coexisting with Behçet's disease. A 49-year-old man, with a diagnosis of Behçet's Disease for 15 years who was found to have an acute kidney injury. His investigations reve...
Maria Rauf,Sambit Sen,Adam Levene et al.
Maria Rauf et al.
A 68-year-old gentleman presented to hepatology department with asymptomatic year-long history of stably deranged liver function tests. His peak alkaline phosphatase (ALP), was 828 with alanine transaminase (ALT) of 141. Full liver workup w...
Muhammad Shipa,Maria Di Cicco,Euthalia Roussou
Muhammad Shipa
A 52-year-old woman known to have anti-synthetase syndrome (ASS) with positive anti-alanyl-tRNA synthetase antibody (anti-PL 12) for 4 years presented with headache and progressive deterioration of cognitive functions manifested predominant...
Hasan Anari,Afsaneh Enteshari-Moghaddam,Yeghaneh Abdolzadeh
Hasan Anari
Objective: Levels of Vitamin D may influence the development of knee osteoarthritis (OA), which is one of the most common joint diseases. The aim of this study was to investigate the association between serum Vitamin D de...
Ilke Coskun Benlidayi
Ilke Coskun Benlidayi
Science and related research activities are always subject to errors. Statistical accuracy is necessary in order to overcome erroneous researching and reporting practices. The present article aimed to review the current literature on statis...