Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field [0.03%]
建立联系：在痴呆症研究领域创建一个跨地区指导和网络构建的在线空间
Josie Fullerton,Conceicao Bettencourt,Michael Daniels et al.
Josie Fullerton et al.
Background: Effective development and retention of talented early-career researchers (ECRs) is essential to the continued success of biomedical science research fields. To this end, formal mentorship programmes (where res...
Inclusion of palliative and end of life care in health strategies aimed at integrated care: a documentary analysis [version 2; peer review: 2 approved] [0.03%]
姑息治疗和临终关怀在以整合护理为目标的卫生策略中的纳入情况：文献分析
Rachel L Chambers,Sophie Pask,Irene J Higginson et al.
Rachel L Chambers et al.
Background: In England, Integrated Care Systems have been established to improve integration of care, as part of the NHS Long Term Plan. For people near the end of life, palliative care can improve integration of care. We...
Validation of the 4AT tool for delirium assessment in specialist palliative care settings: protocol of a prospective diagnostic test accuracy study [version 1; peer review: 2 approved] [0.03%]
用于姑息治疗环境中谵妄评估的4AT工具验证：诊断准确性前瞻性试验研究方案
Elizabeth Arnold,Anne M Finucane,Juliet A Spiller et al.
Elizabeth Arnold et al.
Background: Delirium is a serious and distressing neuropsychiatric condition, which is prevalent across all palliative care settings. Hypoactive delirium is particularly common, but difficult to recognize, partly due to o...
Real-world Independent Testing of e-ASPECTS Software (RITeS): statistical analysis plan [0.03%]
e-ASPECTS软件独立真实世界测试(RITeS)统计分析计划
Grant Mair,Francesca Chappell,Chloe Martin et al.
Grant Mair et al.
Background: Artificial intelligence-based software may automatically detect ischaemic stroke lesions and provide an Alberta Stroke Program Early CT score (ASPECTS) on CT, and identify arterial occlusion and provide a collateral score on CTA...
A feasibility pilot study of the effects of neurostimulation on swallowing function in Parkinson's Disease [version 2; peer review: 1 approved, 3 approved with reservations, 1 not approved] [0.03%]
帕金森病患者神经刺激对吞咽功能影响的可行性试点研究版本2；同行评审：1名批准，3名有条件批准，1名未批准）
Ayodele Sasegbon,Ulrike Hammerbeck,Emilia Michou et al.
Ayodele Sasegbon et al.
Introduction: Dysphagia often occurs during Parkinson's disease (PD) and can have severe consequences. Recently, neuromodulatory techniques have been used to treat neurogenic dysphagia. Here we aimed to compare the neurop...
A collaborative approach to exercise provision for people with Parkinson's - a feasibility and acceptability study of the PDConnect programme [version 2; peer review: 2 approved] [0.03%]
针对帕金森病患者的运动提供合作方法——PDConnect项目的可行性和可接受性研究版本2；同行评审：2项获批）
Julie Jones,Lyndsay Alexander,Elizabeth Hancock et al.
Julie Jones et al.
Background: Exercise has been shown to be beneficial for people with Parkinson's (PwP), slowing the rate of decline of motor and nonmotor symptoms, with emerging evidence associating exercise with a neuroprotective effect...
Detrimental effect of zwitterionic buffers on lysosomal homeostasis in cell lines and iPSC-derived neurons [0.03%]
两性离子缓冲液对细胞系和诱导多能干细胞来源的神经元溶酶体稳态的不利影响
Sophie R Cook,Rafael A Badell-Grau,Emily D Kirkham et al.
Sophie R Cook et al.
Good's buffers are commonly used for cell culture and, although developed to have minimal to no biological impact, they cause alterations in cellular processes such as autophagy and lysosomal enzyme activity. Using Chinese hamster ovary cel...
Clinical and radiological features that predict malignant transformation in cystic lesions of the pancreas: a retrospective case note review [0.03%]
胰腺囊性病变恶性转化的临床及影像学特征：基于病例记录的回顾性分析
Margaret G Keane,Hannah R Dadds,Ghassan El Sayed et al.
Margaret G Keane et al.
Background: Pancreatic cystic lesions (PCL) are being detected with increasing frequency. Current methods of stratifying risk of malignant transformation are imperfect. This study aimed to determine the frequency of pancreatic malignancy in...
Pentraxin 3 regulates neutrophil infiltration to the brain during neuroinflammation [0.03%]
神经炎症期间pentraxin 3调节中性粒细胞向脑组织浸润
Ivana Rajkovic,Raymond Wong,Eloise Lemarchand et al.
Ivana Rajkovic et al.
Introduction: The acute phase protein pentraxin 3 (PTX3) is known for its anti-inflammatory effects through downregulating neutrophil transmigration during peripheral inflammation. Furthermore, we have previously demonstrated a neuroprotect...