Detection of ERG11 gene mutation in coding and non-coding regions of clinical Candida glabrata (Nakaseomyces glabratus) isolates from Pakistan [0.03%]
巴基斯坦临床光滑念珠菌（Nakaseomyces glabratus）分离株ERG11基因编码区和非编码区突变的检测
Saba Memon,Najia Karim Ghanchi,Urooj Zafar et al.
Saba Memon et al.
Azoles inhibit the cytochrome P450-dependent enzyme lanosterol 14α-demethylase (CYP51) that is encoded by the ERG11 gene. Azole resistance in Candida species arises through different mechanisms, like mutations in the ERG11 gene, ERG11 over...
Yassine Ben Lahlou,Zakaria Laanibi,Zakaria Malihy et al.
Yassine Ben Lahlou et al.
Genitourinary tuberculosis is a severe form of extrapulmonary tuberculosis. The kidneys are the most commonly affected organs, followed by the epididymis, testicles, bladder, ureter and prostate. Notably, epididymal tuberculosis is one of t...
In vitro activity of cefiderocol against Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis [0.03%]
体外研究塞来西托仑对成人囊性纤维化患者分离的铜绿假单胞菌的作用活性
Saied Ali,Sinead McDermott
Saied Ali
Background. Pseudomonas aeruginosa is a key pathogen in cystic fibrosis (CF), driving pulmonary decline and exhibiting resistance through virulence factors and adaptive mutations. Cefiderocol (FDC) is a novel siderophore cephalosporin with ...
Direct RNA sequencing reveals m6A modifications and isoform changes in SARS-CoV-2-infected HEK cells [0.03%]
直接RNA测序揭示SARS-CoV-2感染的HEK细胞中m6A修饰和同工型变化
Ilhan Cem Duru,Zlatka Plavec,Anne Ylinen et al.
Ilhan Cem Duru et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers complex host responses, including alterations in RNA transcription and modification. Understanding these changes is crucial for elucidating viral pathogenes...
Antibacterial activity of Cinnamomum verum and Thymus vulgaris essential oils on multidrug-resistant zoonotic bacteria isolated from dogs in southern Benin [0.03%]
肉桂和百里香精油对贝宁南部狗源多重耐药人畜共患病菌抗菌活性的研究
Ayaovi Bruno Yaovi,Arpita Das,Rama N Behera et al.
Ayaovi Bruno Yaovi et al.
Antibiotic resistance is a major public health problem. The search for new therapeutic alternatives is becoming urgent. Essential oils are a promising alternative. This study aimed to evaluate the antibacterial activities of essential oils ...
Analysis of the sheep (Ovis aries) vaginal microbiota preceding spontaneous abortion: a pilot study [0.03%]
绵羊(Ovis aries)自发流产前阴道微生态分析：一项初步研究
Lucille C Jonas,Stephan Schmitz-Esser,Curtis R Youngs
Lucille C Jonas
Little is known regarding the vaginal microbiota of sheep that undergo spontaneous abortions. The aim of this pilot study was to characterize, using 16S rRNA gene sequencing and shotgun metagenomics, the vaginal microbiota throughout the ge...
A novel enrichment-free, low-volume filtration and rapid lysis (ELR) method in combination with real-time PCR for detection of Shiga toxin-producing Escherichia coli (STEC) in water [0.03%]
一种新型的免富集、低体积过滤和快速裂解(ELR)方法结合实时PCR检测水中的志贺毒素产生型大肠杆菌(STEC)
Zina Alfahl,Louise O&#x;Connor,Dearbháile Morris et al.
Zina Alfahl et al.
Consequences of Shiga toxin-producing Escherichia coli (STEC) infection can range in severity from asymptomatic infection to haemolytic uraemic syndrome, renal failure and death. Groundwater-derived drinking water is an important route for ...
16S rRNA gene sequencing reveals bacterial diversity in Khewra Salt Mine walls [0.03%]
基于16S rDNA测序的凯维拉盐矿壁细菌多样性研究
Syeda Wardah Noor,Sara Arshad,Syed Muhammad Abdullah et al.
Syeda Wardah Noor et al.
The Khewra Salt Mine, also known as the source of Himalayan Pink Salt, is the second largest salt mine in the world and a significant site for salt export. The mine's salt exhibits both amorphous and crystalline textures, with colours rangi...
Functional characterization of engineered bacterial biosensors for kynurenine detection [0.03%]
工程菌株色氨酸代谢产物检测细菌传感器的鉴定及功能表征研究
Pisit Charoenwongwatthana,Halah Ahmed,Wojciech Cajdler et al.
Pisit Charoenwongwatthana et al.
The kynurenine (KYN) pathway is the major catabolic pathway for tryptophan in humans, producing several metabolites that influence health. In clinical settings, KYN levels serve as a valuable biomarker for the diagnosis and prognosis of inf...
Parapipe: a pipeline for parasite next-generation sequencing data analysis applied to Cryptosporidium [0.03%]
应用于隐孢子虫的寄生虫下一代测序数据分析流程Pараpipe
Arthur V Morris,Guy Robinson,Rachel Chalmers et al.
Arthur V Morris et al.
Cryptosporidium, a protozoan parasite of significant public health concern, is responsible for severe diarrhoeal disease, particularly in immunocompromised individuals and young children in resource-limited settings. Analysis of whole-genom...