A prospective study on the evaluation of a novel immunochromatographic card for the rapid detection of five carbapenemase enzymes in metallo-beta-lactamase producers [0.03%]
五种金属β-内酰胺酶产生菌的卡巴 penemase 酶新型免疫层析卡片检测的前瞻性研究
Jyotsna Agarwal,Vikramjeet Singh,Avneesh Sharma et al.
Jyotsna Agarwal et al.
Objective. To evaluate the performance of a novel immunochromatographic (IC) card test (TRURAPID® O.K.N.V.I. RESIST-5) for rapid detection of five carbapenemase enzymes in metallo-beta-lactamase (MBL)-producing organisms, compared to real-...
Allele-linked divergence in SlpA and TcdB drives distinct immune and cytotoxic responses that distinguish ST01 from non-ST01 strains in Clade 2 Clostridioides difficile [0.03%]
芽孢菌群2中ST01和非ST01艰难梭杆菌株之间SlpA和TcdB的等位基因连锁差异导致了不同的免疫反应和细胞毒性反应
Adriana Badilla-Lobo,Carlos Quesada-Gómez,Esteban Chaves-Olarte et al.
Adriana Badilla-Lobo et al.
Among the five MLST clades that define the global population structure of the bacterial pathogen Clostridioides difficile, Clade 2 has received special attention due to the global spread, clinical severity and hospital prevalence of ST01 st...
A novel case of prosthetic joint infection due to Clostridioides difficile successfully suppressed with oral doxycycline [0.03%]
一例艰难梭菌假体关节感染口服多西环素治疗成功病例报告
Holly Jordan,Rikki Graham,Sanmarie Schlebusch et al.
Holly Jordan et al.
Extra-colonic infections caused by Clostridioides difficile are exceptionally rare, with prosthetic joint infections (PJIs) comprising only a small fraction of the reported cases. Moreover, there is limited guidance on the optimal managemen...
Detection of ERG11 gene mutation in coding and non-coding regions of clinical Candida glabrata (Nakaseomyces glabratus) isolates from Pakistan [0.03%]
巴基斯坦临床光滑念珠菌（Nakaseomyces glabratus）分离株ERG11基因编码区和非编码区突变的检测
Saba Memon,Najia Karim Ghanchi,Urooj Zafar et al.
Saba Memon et al.
Azoles inhibit the cytochrome P450-dependent enzyme lanosterol 14α-demethylase (CYP51) that is encoded by the ERG11 gene. Azole resistance in Candida species arises through different mechanisms, like mutations in the ERG11 gene, ERG11 over...
Yassine Ben Lahlou,Zakaria Laanibi,Zakaria Malihy et al.
Yassine Ben Lahlou et al.
Genitourinary tuberculosis is a severe form of extrapulmonary tuberculosis. The kidneys are the most commonly affected organs, followed by the epididymis, testicles, bladder, ureter and prostate. Notably, epididymal tuberculosis is one of t...
In vitro activity of cefiderocol against Pseudomonas aeruginosa isolated from adult patients with cystic fibrosis [0.03%]
体外研究塞来西托仑对成人囊性纤维化患者分离的铜绿假单胞菌的作用活性
Saied Ali,Sinead McDermott
Saied Ali
Background. Pseudomonas aeruginosa is a key pathogen in cystic fibrosis (CF), driving pulmonary decline and exhibiting resistance through virulence factors and adaptive mutations. Cefiderocol (FDC) is a novel siderophore cephalosporin with ...
Direct RNA sequencing reveals m6A modifications and isoform changes in SARS-CoV-2-infected HEK cells [0.03%]
直接RNA测序揭示SARS-CoV-2感染的HEK细胞中m6A修饰和同工型变化
Ilhan Cem Duru,Zlatka Plavec,Anne Ylinen et al.
Ilhan Cem Duru et al.
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection triggers complex host responses, including alterations in RNA transcription and modification. Understanding these changes is crucial for elucidating viral pathogenes...
Antibacterial activity of Cinnamomum verum and Thymus vulgaris essential oils on multidrug-resistant zoonotic bacteria isolated from dogs in southern Benin [0.03%]
肉桂和百里香精油对贝宁南部狗源多重耐药人畜共患病菌抗菌活性的研究
Ayaovi Bruno Yaovi,Arpita Das,Rama N Behera et al.
Ayaovi Bruno Yaovi et al.
Antibiotic resistance is a major public health problem. The search for new therapeutic alternatives is becoming urgent. Essential oils are a promising alternative. This study aimed to evaluate the antibacterial activities of essential oils ...
Analysis of the sheep (Ovis aries) vaginal microbiota preceding spontaneous abortion: a pilot study [0.03%]
绵羊(Ovis aries)自发流产前阴道微生态分析：一项初步研究
Lucille C Jonas,Stephan Schmitz-Esser,Curtis R Youngs
Lucille C Jonas
Little is known regarding the vaginal microbiota of sheep that undergo spontaneous abortions. The aim of this pilot study was to characterize, using 16S rRNA gene sequencing and shotgun metagenomics, the vaginal microbiota throughout the ge...
A novel enrichment-free, low-volume filtration and rapid lysis (ELR) method in combination with real-time PCR for detection of Shiga toxin-producing Escherichia coli (STEC) in water [0.03%]
一种新型的免富集、低体积过滤和快速裂解(ELR)方法结合实时PCR检测水中的志贺毒素产生型大肠杆菌(STEC)
Zina Alfahl,Louise O&#x;Connor,Dearbháile Morris et al.
Zina Alfahl et al.
Consequences of Shiga toxin-producing Escherichia coli (STEC) infection can range in severity from asymptomatic infection to haemolytic uraemic syndrome, renal failure and death. Groundwater-derived drinking water is an important route for ...