Exosomal miRNAs and isomiRs: potential biomarkers for type 2 diabetes mellitus [0.03%]
外泌体miRNA和等位基因miRNA：2型糖尿病潜在生物标志物
Yong Ling Sou,William M Chilian,Wickneswari Ratnam et al.
Yong Ling Sou et al.
Type 2 diabetes mellitus (T2DM) is a metabolic disease that is characterized by chronic hyperglycaemia. MicroRNAs (miRNAs) are single-stranded, small non-coding RNAs that play important roles in post-transcriptional gene regulation. They ar...
Communication between cancer cell subtypes by exosomes contributes to nasopharyngeal carcinoma metastasis and poor prognosis [0.03%]
鼻咽癌细胞亚型通过外泌体交流促进癌症转移和预后不良
Hao-Jun Xie,Ming-Jie Jiang,Ke Jiang et al.
Hao-Jun Xie et al.
Background: Intratumor heterogeneity is common in cancers, with different cell subtypes supporting each other to become more malignant. Nasopharyngeal carcinoma (NPC), a highly metastatic cancer, shows significant heterog...
Phenotypic age mediates effects of Life's Essential 8 on reduced mortality risk in US adults [0.03%]
生命 essentials of 8对美国成年人降低死亡风险的影响通过表型年龄介导
Yuxuan Zhao,Haiming Yang,Rong Jiao et al.
Yuxuan Zhao et al.
Objective: This study aimed to find out whether phenotypic age could mediate the protective effects of a healthy lifestyle on mortality. Methods: ...
Lipid nanoparticle-based mRNA vaccines: a new frontier in precision oncology [0.03%]
基于脂质纳米颗粒的mRNA疫苗：精准肿瘤学的新前沿
Eden M Jacob,Jiaoti Huang,Ming Chen
Eden M Jacob
The delivery of lipid nanoparticle (LNP)-based mRNA therapeutics has captured the attention of the vaccine research community as an innovative and versatile tool for treating a variety of human malignancies. mRNA vaccines are now in the lim...
Zheng-Yang Guo,Yan-Qing Tang,Zi-Bo Zhang et al.
Zheng-Yang Guo et al.
The coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has highlighted the pivotal role of the immune response in determining the progression and severity of viral infections. In...
Computational insights into CRISP3 downregulation in cervical cancer and its cervical lineages pattern [0.03%]
CRISP3在宫颈癌下调的计算研究及其在宫颈谱系中的模式分析
Ricardo Cesar Cintra,Andrés Galindo Céspedes,Mércia Patrícia Ferreira Conceição et al.
Ricardo Cesar Cintra et al.
Background: Cysteine-rich secretory protein 3 (CRISP3) emerges as a potential biomarker in the study of many cancers, including cervical cancer (CC). This study aimed to analyze the expression pattern of CRISP3 in CC pati...
Suppression of MyD88 disturbs gut microbiota and activates the NLR pathway and hence fails to ameliorate DSS-induced colitis [0.03%]
抑制MyD88扰乱肠道微生物群并激活NLR途径，从而无法缓解DSS诱导的结肠炎
Jun-Hua Li,Yu Chen,Zheng-Hao Ye et al.
Jun-Hua Li et al.
Background: Myeloid differentiation factor 88 (MyD88) is the core adaptor for Toll-like receptors defending against microbial invasion and initiating a downstream immune response during microbiota-host interaction. Howeve...
Deep learning-based multi-modal data integration enhancing breast cancer disease-free survival prediction [0.03%]
基于深度学习的多模态数据集成增强乳腺癌无病生存预测
Zehua Wang,Ruichong Lin,Yanchun Li et al.
Zehua Wang et al.
Background: The prognosis of breast cancer is often unfavorable, emphasizing the need for early metastasis risk detection and accurate treatment predictions. This study aimed to develop a novel multi-modal deep learning m...
Depletion of squalene epoxidase in synergy with glutathione peroxidase 4 inhibitor RSL3 overcomes oxidative stress resistance in lung squamous cell carcinoma [0.03%]
与谷胱甘肽过氧化物酶4抑制剂RSL3联合消耗角鲨烯环氧酶可克服肺鳞状细胞癌的氧化应激抗性
Guo Li,Lu Chen,Hua Bai et al.
Guo Li et al.
Background: Lung squamous cell carcinoma (LUSC) lacks effective targeted therapies and has a poor prognosis. Disruption of squalene epoxidase (SQLE) has been implicated in metabolic disorders and cancer. However, the role...