Precision medication based on the evaluation of drug metabolizing enzyme and transporter functions [0.03%]
基于药物代谢酶和转运蛋白功能评价的精准用药研究
Yanrong Ma,Jing Mu,Xueyan Gou et al.
Yanrong Ma et al.
Pharmacogenomics, therapeutic drug monitoring, and the assessments of hepatic and renal function have made significant contributions to the advancement of individualized medicine. However, their lack of direct correlation with protein abund...
Liquid biopsy in head and neck cancer patients: blood, saliva, or both ? [0.03%]
头颈部肿瘤患者的液体活检：血液、唾液，还是两者？
Valentina De Pascale,Federica Ganci,Fabrizio Leone et al.
Valentina De Pascale et al.
Spatially defined intratumoral immune biomarkers predict recurrent versus second primary tumors in non-small cell lung cancer [0.03%]
空间定义的肿瘤内免疫生物标志物可预测非小细胞肺癌中复发肿瘤和第二原发肿瘤
Rekha Mudappathi,Alanna Maguire,Eunhee S Yi et al.
Rekha Mudappathi et al.
Predictive model for daily risk alerts in sepsis patients in the ICU: visualization and clinical analysis of risk indicators [0.03%]
ICU中脓毒症患者每日风险预警预测模型：风险因素的可视化及临床分析
Hao Yang,Jiaxi Li,Chi Zhang et al.
Hao Yang et al.
This study introduces a novel Transformer-based time-series framework designed to revolutionize risk stratification in Intensive Care Units (ICUs) by predicting patient outcomes with high temporal precision. Leveraging sequential data from ...
Epstein-Barr virus infection exacerbates ulcerative colitis by driving macrophage pyroptosis via the upregulation of glycolysis [0.03%]
通过提高糖酵解来驱动巨噬细胞焦亡从而加重溃疡性结肠炎的Epstein-Barr病毒感染
Chunxiang Ma,Kexin Chen,Lili Li et al.
Chunxiang Ma et al.
Background: Epstein-Barr virus (EBV) infection is associated with clinical symptoms, treatment response, need for surgical intervention, and an enhanced likelihood of lymphoma among patients with ulcerative colitis (UC). ...
MET inhibitors as salvage therapy for MET-amplified gastric cancer with pulmonary lymphangitis [0.03%]
ROS1抑制剂治疗胃癌肺淋巴管炎和ROS1放大化疗法失败的病例
Xiufeng Zheng,Mo Cheng,Wenke Li et al.
Xiufeng Zheng et al.
Cell-free tumor DNA analysis in advanced or metastatic breast cancer patients: mutation frequencies, testing intention, and clinical impact [0.03%]
循环肿瘤DNA在晚期或转移性乳腺癌患者中的分析：突变频率、检测意图及临床影响
Hanna Huebner,Pauline Wimberger,Elena Laakmann et al.
Hanna Huebner et al.
Background: Circulating cell-free tumor DNA (ctDNA) provides a non-invasive approach for assessing somatic alterations. The German PRAEGNANT registry study aims to explore molecular biomarkers and investigate their integr...
Dual anti-HER2 therapy combined with chemotherapy as a novel neoadjuvant treatment option for locally advanced HER2-positive and microsatellite stable colon cancer [0.03%]
新型新辅助治疗方案——双靶联合化疗治疗局部晚期微卫星稳定型HER2阳性结肠癌
Huayang Pang,Xiufeng Chen,Menghua Yan et al.
Huayang Pang et al.
Exosomes of stem cells: a potential frontier in the treatment of osteoarthritis [0.03%]
干细胞外泌体在骨关节炎治疗中的应用前景初探
Xiaofei Wang,Lei Xu,Zhimin Wu et al.
Xiaofei Wang et al.
The aging population has led to a global issue of osteoarthritis (OA), which not only impacts the quality of life for patients but also poses a significant economic burden on society. While biotherapy offers hope for OA treatment, currently...
Comparative analysis of tertiary lymphoid structures for predicting survival of colorectal cancer: a whole-slide images-based study [0.03%]
基于全切片图象的结直肠癌三级淋巴器官结构生存预测价值的定量分析研究
Ming He,Huifen Ye,Liu Liu et al.
Ming He et al.
Background: Tertiary lymphoid structures (TLS) are major components in the immune microenvironment, correlating with a favorable prognosis in colorectal cancer. However, the methods used to define and characterize TLS wer...