Deep learning-based multi-modal data integration enhancing breast cancer disease-free survival prediction [0.03%]
基于深度学习的多模态数据集成增强乳腺癌无病生存预测
Zehua Wang,Ruichong Lin,Yanchun Li et al.
Zehua Wang et al.
Background: The prognosis of breast cancer is often unfavorable, emphasizing the need for early metastasis risk detection and accurate treatment predictions. This study aimed to develop a novel multi-modal deep learning m...
Depletion of squalene epoxidase in synergy with glutathione peroxidase 4 inhibitor RSL3 overcomes oxidative stress resistance in lung squamous cell carcinoma [0.03%]
与谷胱甘肽过氧化物酶4抑制剂RSL3联合消耗角鲨烯环氧酶可克服肺鳞状细胞癌的氧化应激抗性
Guo Li,Lu Chen,Hua Bai et al.
Guo Li et al.
Background: Lung squamous cell carcinoma (LUSC) lacks effective targeted therapies and has a poor prognosis. Disruption of squalene epoxidase (SQLE) has been implicated in metabolic disorders and cancer. However, the role...
TP53-specific mutations serve as a potential biomarker for homologous recombination deficiency in breast cancer: a clinical next-generation sequencing study [0.03%]
TP53特异性突变可作为乳腺癌同源重组缺陷的潜在生物标志物：一项临床下一代测序研究
Yongsheng Huang,Shuwei Ren,Linxiaoxiao Ding et al.
Yongsheng Huang et al.
Background: TP53 mutations and homologous recombination deficiency (HRD) occur frequently in breast cancer. However, the characteristics of TP53 pathogenic mutations in breast cancer patients with/without HRD are not clea...
High PSMA expression is associated with immunosuppressive tumor microenvironment in clear cell renal cell carcinoma [0.03%]
高PSMA表达与透明细胞肾细胞癌免疫抑制性肿瘤微环境相关
Panagiotis J Vlachostergios,Athanasios Karathanasis,Konstantinos Dimitropoulos et al.
Panagiotis J Vlachostergios et al.
Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients [0.03%]
癌症患者围手术期循环DNA水平及中性粒细胞胞外陷阱形成的动态变化及其相关性分析
Andrei Kudriavtsev,Brice Pastor,Alexia Mirandola et al.
Andrei Kudriavtsev et al.
Objectives: Elevated circulating DNA (cirDNA) concentrations were found to be associated with trauma or tissue damage which suggests involvement of inflammation or cell death in post-operative cirDNA release. We carried o...
Zhen Zeng,Mingshan Jiang,Xi Li et al.
Zhen Zeng et al.
Inflammatory bowel disease (IBD) is an incurable disease characterized by remission-relapse cycles throughout its course. Both Crohn's disease (CD) and ulcerative colitis (UC), the two main forms of IBD, exhibit tendency to develop complica...
Genome and clonal hematopoiesis stability contrasts with immune, cfDNA, mitochondrial, and telomere length changes during short duration spaceflight [0.03%]
基因组和克隆造血稳定性与短期太空飞行期间免疫系统、循环游离DNA、线粒体以及端粒长度变化的对比研究
J Sebastian Garcia-Medina,Karolina Sienkiewicz,S Anand Narayanan et al.
J Sebastian Garcia-Medina et al.
Background: The Inspiration4 (I4) mission, the first all-civilian orbital flight mission, investigated the physiological effects of short-duration spaceflight through a multi-omic approach. Despite advances, there remains...
Circle-map profiling of extrachromosomal circular DNA as diagnostic biomarkers for lung cancer [0.03%]
用于肺癌诊断的细胞外环状DNA的圆图谱分析
Yongfeng Yang,Tingting Song,Sha Liu et al.
Yongfeng Yang et al.
Accurate prediction of myopic progression and high myopia by machine learning [0.03%]
机器学习准确预测近视加深和高度近视
Jiahui Li,Simiao Zeng,Zhihuan Li et al.
Jiahui Li et al.
Background: Myopia is a leading cause of visual impairment in Asia and worldwide. However, accurately predicting the progression of myopia and the high risk of myopia remains a challenge. This study aims to develop a pred...
Extracellular vesicles derived from mesenchymal stem cells: the wine in Hebe's hands to treat skin aging [0.03%]
来源于间充质干细胞的细胞外囊泡：抗衰老的不老酒
Qixiang Gui,Neng Ding,Zuochao Yao et al.
Qixiang Gui et al.
Owing to its constant exposure to the external environment and various stimuli, skin ranks among the organs most vulnerable to manifestations of aging. Preventing and delaying skin aging has become one of the prominent research subjects in ...