RNA modifications in health and disease: from mechanistic insights to therapeutic applications [0.03%]
RNA修饰在健康与疾病中的作用：从机制研究到治疗应用
Yiting Chen,Dulin Ding,Xing Tang et al.
Yiting Chen et al.
RNA modifications encompass a series of dynamic chemical changes and editing events on RNA molecules, playing a pivotal role in essential physiological processes such as embryonic development, immune response, and the maintenance of cell ho...
Jing An,Qingyi Jia,Yan Huang et al.
Jing An et al.
More than 500 million Chinese adults suffered from overweight or obesity in 2023. The pandemic of obesity consumes healthcare and economic resources by imposing enormous burden from its complications such as cardiovascular, kidney and metab...
Randomized controlled clinical trial of Shenzhuo Formula in the treatment of macroalbuminuria in diabetic kidney disease and its inflammation-modulating mechanisms [0.03%]
治疗糖尿病肾病大量白蛋白尿的缩泉丸随机对照临床试验及其抗炎机制研究
Anzhu Wang,Yishan Huang,Yu Wei et al.
Anzhu Wang et al.
Background: Shenzhuo Formula (SZF), a modified Didang Tang, is used for diabetic kidney disease (DKD), though high-quality evidence is limited. Methods: ...
Insights into the mechanisms of microRNAs in hepatoblastoma: from diagnosis to treatment [0.03%]
microRNA在肝母细胞瘤诊疗中的作用机制探讨
Meng Kong,Shisong Zhang,Xiang Ma
Meng Kong
Hepatoblastoma (HB) is the most common malignant liver tumor in children. Early diagnosis and effective treatment are crucial for improving the prognosis of children with HB. In recent years, microRNAs (miRNAs), an important class of noncod...
The irreplaceable role of pathology for the clinical translation of patient-derived organoids in precision medicine [0.03%]
精准医疗中基于患者来源类器官的临床转化病理学不可替代的作用
Zuoyu Liang,Ping Yang,Xinglong Zhu et al.
Zuoyu Liang et al.
Endocrinologists in golden age: opportunities enabled by artificial intelligence [0.03%]
内分泌学的黄金时代：人工智能带来的机遇
Bing Li,Qingzheng Wu,Zhaohui Lyu
Bing Li
Anti-diabetic medications and cancer: links beyond glycemic and body weight control [0.03%]
抗糖尿病药物与癌症：控糖和体重之外的关联
Meng Cao,Chu Lin,Xiaoling Cai et al.
Meng Cao et al.
Cancer is becoming one of the leading causes of death among patients with diabetes. Hyperglycemia and obesity, two key characteristics of type 2 diabetes, modify the risks of cancer in patients with type 2 diabetes. However, recent studies ...
SKP2 at the crossroads of proliferation and immune evasion: a new target in the tumor microenvironment [0.03%]
SKP2在增殖和免疫逃逸的交叉路口：肿瘤微环境中的新靶点
Panagiotis J Vlachostergios,Stergios Boussios
Panagiotis J Vlachostergios
Metabolic regulation of T cell production of IL-10 and IL-22 protects against intestinal inflammation [0.03%]
代谢调节T细胞产生IL-10和IL-22可保护肠道免受炎症侵害
Han Liu,Xiaojing Zhao,Tianming Yu et al.
Han Liu et al.
Objectives: Inflammatory bowel disease is driven by dysregulated CD4⁺ T cell responses to the intestinal microbiota. While T cells can exacerbate inflammation by producing proinflammatory cytokines, they also produce ant...