The size of cell-free mitochondrial DNA in blood is inversely correlated with tumor burden in cancer patients [0.03%]
癌症患者血循环中无细胞线粒体DNA含量与肿瘤负荷呈负相关性分布规律研究
Qin An,Youjin Hu,Qingjiao Li et al.
Qin An et al.
Circulating cell-free DNAs (cfDNAs) are fragmented DNA molecules released into the blood by cells. Previous studies have suggested that mitochondria-originated cfDNA fragments (mt-cfDNAs) in cancer patients are more fragmented than those fr...
Quantile regression for survival data in modern cancer research: expanding statistical tools for precision medicine [0.03%]
现代癌症研究中的生存数据分析：精准医疗的统计工具拓展——量回归方法及其应用
Hyokyoung G Hong,David C Christiani,Yi Li
Hyokyoung G Hong
Quantile regression links the whole distribution of an outcome to the covariates of interest and has become an important alternative to commonly used regression models. However, the presence of censored data such as survival time, often the...
Gut microbiota metabolite regulation of host defenses at mucosal surfaces: implication in precision medicine [0.03%]
肠菌代代谢产物调节黏膜表面的宿主防御：在精准医疗中的应用
Anthony J Bilotta,Yingzi Cong
Anthony J Bilotta
The gut microbiota has a well-established role in the regulation of host homeostasis. Multiple factors control the composition and function of the microbiota. The westernization of diet, a shift away from nutrient-dense foods toward diets h...
Big DNA as a tool to dissect an age-related macular degeneration-associated haplotype [0.03%]
大规模DNA作为工具用于分解与年龄相关性黄斑变性相关的单体型
Jon M Laurent,Xin Fu,Sergei German et al.
Jon M Laurent et al.
Age-related Macular Degeneration (AMD) is a leading cause of blindness in the developed world, especially in aging populations, and is therefore an important target for new therapeutic development. Recently, there have been several studies ...
Antigen recognition in autoimmune diabetes: a novel pathway underlying disease initiation [0.03%]
自身免疫性糖尿病中的抗原识别：疾病发生的新型途径
Xiaoxiao Wan,Emil R Unanue
Xiaoxiao Wan
Development of human autoimmune disorders results from complex interplay among genetic, environmental, and immunological risk factors. Despite much heterogeneity in environmental triggers, the leading genes that give the propensity for tiss...
Tian Zhang,Andrew J Armstrong,Daniel J George et al.
Tian Zhang et al.
A broad understanding of the tumor immune landscape has led to a revolution of immune checkpoint inhibitors in the treatment of multiple cancer types. In genitourinary malignancies, immune checkpoint inhibitors have improved outcomes for pa...
Ming Liu,Fukun Guo
Ming Liu
Traditional cancer therapies include surgery, radiation, and chemotherapy, all of which are typically non-specific approaches. Cancer immunotherapy is a type of cancer treatment that helps the immune system fight cancer. Cancer immunotherap...
Characterization of cancer genomic heterogeneity by next-generation sequencing advances precision medicine in cancer treatment [0.03%]
下一代测序表征癌症基因组异质性促进精准医学在癌症治疗中的应用
Jialing Zhang,Stephan Stanislaw Späth,Sadie L Marjani et al.
Jialing Zhang et al.
Cancer is a heterogeneous disease with unique genomic and phenotypic features that differ between individual patients and even among individual tumor regions. In recent years, large-scale genomic studies and new next-generation sequencing t...
New insights into the pathogenesis and treatment of non-viral hepatocellular carcinoma: a balancing act between immunosuppression and immunosurveillance [0.03%]
非病毒性肝细胞癌的发病机制和治疗的新见解：免疫抑制与免疫监视之间的平衡行为
Michael Karin
Michael Karin
Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. HCC initiates as a consequence of chronic liver damage and inflammation caused by hepatitis B and C virus infections, excessive alcohol consumpt...