Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry [0.03%]
中国和英国血统个体肥厚型心肌病的遗传结构
Jie Wang,Dominic Russ,Yongsan Yang et al.
Jie Wang et al.
Background: No studies have explored the genetic differences between the Chinese and other ethnic hypertrophic cardiomyopathy (HCM) populations. Methods: ...
Yingying Ling,Fei Cai,Tao Su et al.
Yingying Ling et al.
Protein glycosylation is a critical post-translational modification that influences protein folding, localization, stability, and functional interactions by attaching glycans to specific sites. This process is crucial for biological functio...
AlphaFold 3: an unprecedent opportunity for fundamental research and drug development [0.03%]
AlphaFold3：基础研究和药物发现的一个前所未有的机遇
Ziqi Fang,Hongbiao Ran,YongHan Zhang et al.
Ziqi Fang et al.
AlphaFold3 (AF3), as the latest generation of artificial intelligence model jointly developed by Google DeepMind and Isomorphic Labs, has been widely heralded in the scientific research community since its launch. With unprecedented accurac...
Utilizing multimodal artificial intelligence to advance cardiovascular diseases [0.03%]
利用多模态人工智能推进心血管疾病诊疗
Xin-Yue Yang,Yi-Ming Li,Jian-Yong Wang et al.
Xin-Yue Yang et al.
The emergence of artificial intelligence (AI) is transforming cardiovascular medicine. Initially, AI applications concentrated on analyzing single data types, such as electrocardiograms and imaging studies. However, advancements in multimod...
Decoding hepatobiliary-specific immune gene patterns in gastrointestinal cancers via gene ontology fingerprints, multi-omics, and experimental integration [0.03%]
基于基因本体指纹、多组学和实验整合解码胃肠道癌症的肝胆特异性免疫基因模式
Honglian Huang,Yueping Zhan,Hui Zong et al.
Honglian Huang et al.
Background: Gastrointestinal (GI) cancers are characterized by high malignancy and poor prognosis. Tumors in different locations exhibit both commonalities and differences. Although immunotherapy has made progress in some...
A benchmarking study of copy number variation inference methods using single-cell RNA-sequencing data [0.03%]
基于单细胞RNA测序数据的拷贝数变异推断方法基准研究
Xin Chen,Li Tai Fang,Zhong Chen et al.
Xin Chen et al.
Background: Single-cell RNA-sequencing (scRNA-seq) has emerged as a powerful tool for cancer research, enabling in-depth characterization of tumor heterogeneity at the single-cell level. Recently, several scRNA-seq copy n...
A multi-omic study profiles women with PCOS to reveal unique gut microbiome compositions [0.03%]
一项多组学研究对PCOS女性进行特征分析以揭示独特的肠道微生物组成
Loukia Lili,Laura J Kunces,Cem Meydan et al.
Loukia Lili et al.
The gut virome in association with the bacteriome in gastrointestinal diseases and beyond: roles, mechanisms, and clinical applications [0.03%]
胃肠疾病相关肠病毒菌和细菌微生物组的作用、机制及临床应用研究
Zhiyang Feng,Elke Burgermeister,Anna Philips et al.
Zhiyang Feng et al.
The gut virome, an essential component of the intestinal microbiome, constitutes ∼0.1% of the total microbial biomass but contains a far greater number of particles than bacteria, with phages making up 90%-95% of this virome. This review s...
Risk factors associated with morbidity and unfavorable treatment outcome in drug-resistant pulmonary tuberculosis: a case-control study [0.03%]
耐多药肺结核患病相关危险因素及不良转归的病例对照研究
Changshu Li,Shufan Liang,Xue Wang et al.
Changshu Li et al.
Objectives: To investigate the risk factors in patients with drug-resistant tuberculosis (DR-TB) and clinical characteristics related to unfavorable anti-TB treatment outcomes. ...
Ultrasound and gene-guided microwave ablation vs. surgery for low-risk papillary thyroid carcinoma: a prospective observational cohort study [0.03%]
低风险乳头状甲状腺癌的超声和基因引导微波消融与手术对照的前瞻性队列研究
Yunfang Yu,Yuxin Shen,Yujie Tan et al.
Yunfang Yu et al.
Objective: This prospective observational cohort real-world study evaluates and compares the efficacy and prognosis of ultrasound (US) and gene-based microwave ablation (MWA) and surgical treatment in patients with low-ri...