Beyond CAR-T and oncology: broadening chimeric antigen receptor technologies across cell types and diseases [0.03%]
CAR-T和肿瘤之外：跨越细胞和疾病拓宽嵌合抗原受体技术
Xiaohong Liu,Hongye Gao,Jianhua Yu
Xiaohong Liu
Chimeric antigen receptor (CAR)-engineered immune cells have revolutionized cancer immunotherapy, expanding from the established success of CAR-T cells to a diverse array of cellular platforms. While seven Food and Drug Administration-appro...
Spatial genomics and brain spatial transcriptomic atlas for precision medicine [0.03%]
空间组学和脑空间转录组图谱在精准医学中的应用
Wei Xiong,Alexander Hindeleh,Charles Wang
Wei Xiong
Artificial intelligence-driven peptide blocks gasdermin pyroptosis and alleviates inflammation [0.03%]
人工智能驱动的肽通过阻断Gasdermin介导的炎性焦亡来减轻炎症
Mingsheng Liu,Hongqing Zhou,Min Wu
Mingsheng Liu
Spatial proteomics in precision medicine: technologies, bioinformatics, and translational applications [0.03%]
精准医学中的空间蛋白质组学：技术、生物信息学及转化应用
Yiwen Li,Yusheng Zhang,Ying Zhang et al.
Yiwen Li et al.
Protein function is inherently spatial: the same molecule can elicit distinct biological outcomes depending on its localization, interacting partners, and surrounding microenvironment. Spatial proteomics enables systematic in situ character...
Antibiotic exposure impairs the efficacy of first-line chemoimmunotherapy in non-small cell lung cancer through the regulation of gut microbiome and bile acid metabolism [0.03%]
抗生素暴露通过调节肠道菌群和胆汁酸代谢损害非小细胞肺癌一线化疗免疫治疗的效果
Hanyan Xu,Jia Yu,Lijing Xia et al.
Hanyan Xu et al.
Objective: Previous antibiotic therapy is acknowledged to potentially reduce the efficacy of single-agent immune checkpoint inhibitors. Nevertheless, the impact of antibiotics on the results for patients undergoing chemoi...
IRF7 orchestrates maladaptive smooth muscle cell phenotype switching in atherosclerosis [0.03%]
IRF7在动脉粥样硬化中促进平滑肌细胞向不良表型转化
Rundong Cai,Xin Chen,Hongxia Zhang et al.
Rundong Cai et al.
Background: Smooth muscle cells (SMCs) exhibit remarkable plasticity, undergoing extensive phenotypic switching to generate a highly heterogeneous population within atherosclerotic plaques. While recent studies have highl...
Identification of factors conferring resistance to trastuzumab deruxtecan in advanced gastric cancer: a translational study from the single-arm, phase II, DESTINY-Gastric06 trial [0.03%]
识别导致局部晚期或转移性胃癌患者对曲妥珠单抗deruxtecan耐药的因素：来自DESTINY-Gastric06 单臂Ⅱ期临床试验的转化研究
Bohan Zhang,Lei Zhang,Cheng Liu et al.
Bohan Zhang et al.
Background: Trastuzumab deruxtecan (T-DXd) has revolutionized the therapeutic landscape for HER2-positive gastric cancer (GC). However, tumor heterogeneity poses a significant challenge in overcoming T-DXd resistance. Thi...
Drug pair-derived synergistic therapy of flavonoids luteolin and astragaloside IV promotes neural repair following spinal cord injury via antioxidant and neuroprotective effects [0.03%]
一种黄酮类化合物芦丁和金雀异黄素的药物组合衍生协同疗法促进脊髓损伤后神经修复的抗氧化和神经营养作用
Wei Lin,Peng Zhang,Defeng Liu et al.
Wei Lin et al.
Background: Spinal cord injury (SCI) induces a damaging oxidative microenvironment exacerbating secondary injury. The traditional Chinese medicine (TCM) drug-pair Dangshen and Huangqi, known for antioxidant and neuroprote...
The recurrence or metastasis related gene predicts the prognosis of extremity and trunk soft tissue sarcoma [0.03%]
复发和转移相关基因用于判断四肢和躯干软组织肉瘤的预后指标研究
Duo Wang,Dawei Sun,Jihao Tu et al.
Duo Wang et al.
Background: Relapsed soft tissue sarcomas (STS) have poor prognosis and limited treatment options. However, the molecular mechanism underlying recurrence and the prognostic predictor for STS are unclear. ...