Protein modification systems as cancer biomarkers and therapeutic targets [0.03%]
蛋白质修饰系统作为癌症生物标志物和治疗靶点
Li Gao,Yueqin He,Kexin Wang et al.
Li Gao et al.
Protein post-translational modifications (PTMs), such as acetylation, lactylation, methylation, phosphorylation, ubiquitination, and glycosylation, play central roles in regulating diverse cellular processes, including signal transduction, ...
Xun Liao,Wenjie Hou,Junxiu Zhou et al.
Xun Liao et al.
Calming sterile inflammation in intervertebral disc degeneration: taurine disrupts mitochondria-cGAS-STING signaling via autophagy enhancement [0.03%]
Taurolidine通过增强自噬抑制椎间盘退变中的线粒体cGAS-STING信号通路诱导的无菌性炎症
Shuangjia Zai,Huofeng Wu,Xuan You et al.
Shuangjia Zai et al.
Background: Intervertebral disc degeneration (IVDD) is a major pathological process leading to low back pain, closely associated with the functional decline of nucleus pulposus progenitor cell (NPPC). The role of the cGAS...
JS-K induces autophagy-dependent ferroptosis in bladder cancer: a multimodal mechanistic and translational study [0.03%]
JS-K诱导膀胱癌铁死亡的自噬依赖性多模态机制和转化研究
Zhuo Li,Haitao Zhong,Daniel Baptista-Hon et al.
Zhuo Li et al.
Background: Bladder cancer is the most common urological malignancy. Bladder cancer has limited therapeutic options, especially in advanced stages. Ferroptosis, an iron-dependent form of regulated cell death, has emerged ...
Circular RNA as emerging precision therapeutics: from RNA regulation to peptide translation [0.03%]
circRNA新兴精准治疗：从RNA调控到多肽表达
Nan Wu,Jeremiah Amalraj,Burton B Yang
Nan Wu
Circular RNAs (circRNAs) are a class of endogenous non-coding RNAs characterized by a covalently closed-loop structure. Although initially regarded as splicing byproducts, circRNAs are now recognized as essential regulators of gene and prot...
Agrimol B inhibits pancreatic ductal adenocarcinoma by induction of lethal mitophagy through decreasing mitochondrial transcription termination factor 3 [0.03%]
Agrimol B通过降低线粒体转录终止因子3诱导致死性自噬抑制胰腺导管腺癌
Yifei Ma,Ying Zheng,Ying Zhou et al.
Yifei Ma et al.
Objective: To investigate the inhibitory effect of the natural polyphenol Agrimol B on pancreatic ductal adenocarcinoma (PDAC) and its underlying molecular mechanisms. ...
Mitochondrial homeostasis: the central hub governing the progression of atherosclerosis [0.03%]
线粒体稳态：调控动脉粥样硬化进展的核心节点
Hao Liu,Shuaiyong Zhao,Huiqin Gao et al.
Hao Liu et al.
Atherosclerosis is a disease centered on chronic inflammation, in which mitochondrial damage plays a key role in its initiation and progression. Traditionally, atherosclerosis is thought to be triggered by cholesterol accumulation, but rece...
Therapeutic strategy for cervical gastric-type adenocarcinoma by targeting CLU to relieve CLU-associated stress and sensitize chemotherapy [0.03%]
靶向CLU治疗宫颈胃型腺癌以缓解CLU相关压力和提高化疗敏感性的治疗策略
Tong Wu,Xinyu Qu,Lili Jiang et al.
Tong Wu et al.
Objectives: Gastric-type adenocarcinoma (GAS), an aggressive subtype of non-human papillomavirus (HPV)-associated (NHPVA) cervical adenocarcinomas (ADC), remains a treatment-refractory disease with poor prognosis. This st...
Linking first-pass reperfusion success to proteomic markers in large and medium vessel ischemic stroke: an exploratory study [0.03%]
溶栓成功与大中血管缺血性卒中的蛋白质标志物的探索性研究
Crhistian-Mario Oblitas,Sabela Fernández-Rodicio,Manuel Rodríguez-Yáñez et al.
Crhistian-Mario Oblitas et al.
Pressure cycling technology-assisted data-independent acquisition proteomics reveals molecular alterations and potential therapeutic targets in minor glomerular abnormalities [0.03%]
压力循环技术辅助的数据非依赖性获取蛋白组学揭示了轻微肾小球异常的分子改变及潜在治疗靶点
Ling Li,Yingying Ling,Fei Cai et al.
Ling Li et al.
Background: Minor glomerular abnormalities (MGAs) are histopathologically heterogeneous renal lesions with subtle structural changes and latent clinical manifestations, yet their molecular mechanisms remain poorly charact...