SKP2 at the crossroads of proliferation and immune evasion: a new target in the tumor microenvironment [0.03%]
SKP2在增殖和免疫逃逸的交叉路口：肿瘤微环境中的新靶点
Panagiotis J Vlachostergios,Stergios Boussios
Panagiotis J Vlachostergios
Metabolic regulation of T cell production of IL-10 and IL-22 protects against intestinal inflammation [0.03%]
代谢调节T细胞产生IL-10和IL-22可保护肠道免受炎症侵害
Han Liu,Xiaojing Zhao,Tianming Yu et al.
Han Liu et al.
Objectives: Inflammatory bowel disease is driven by dysregulated CD4⁺ T cell responses to the intestinal microbiota. While T cells can exacerbate inflammation by producing proinflammatory cytokines, they also produce ant...
Citrullination of CAMP exacerbating mucosal inflammation in inflammatory bowel disease [0.03%]
瓜氨酸化CAMP加重炎症性肠病黏膜炎症
Xin Chang,Haicong Wu,Yihang Song et al.
Xin Chang et al.
Background: Cathelicidin (CAMP), plays important roles in pathogen defense, immune regulation, and epithelial barrier maintenance. While previous studies have highlighted its protective function, the post-translational mo...
Clinical and genomic characteristics of HER2-ultralow breast cancer and implications for T-DXd therapy [0.03%]
HER2超低表达乳腺癌的临床和基因组特征及其对T-DXd治疗的意义
Juan Jin,Tiantian Liu,Mengyuan Cai et al.
Juan Jin et al.
Background: The clinical benefit of T-DXd in advanced breast cancer with hormone receptor-positive (HR+), human epidermal growth factor receptor 2 (HER2)-ultralow tumors in the DESTINY-Breast06 trial has drawn attention t...
CRISPR-based prime editing improves therapeutic outcomes for childhood alternating hemiplegia [0.03%]
基于CRISPR的prime编辑可改善儿童交替性偏瘫的治疗效果
Guanwang Shen,Yingying Liao,Ping Lin
Guanwang Shen
A pan-cancer analysis revealed SKP2 as an inhibitor of the tumor immune microenvironment and a promising therapeutic target for immunotherapy [0.03%]
泛癌分析揭示SKP2是肿瘤免疫微环境的抑制因子和免疫治疗有希望的治疗靶点
Xingyu Liao,Yaxin Zhang,Xue Yu et al.
Xingyu Liao et al.
Background: S-Phase kinase associated protein 2 (SKP2) is a key regulator of the cell cycle and proliferation linked to cancer development. Our recent study has revealed that knocking out Skp2 in a mouse model significant...
Trends of obesity management in adults: an analysis across guidelines in China and in Europe [0.03%]
中国和欧洲成人肥胖管理指南趋势分析
Shen Qu,Le Bu,Jiajun Zhao
Shen Qu
Molecular mechanisms and genetic features of cholangiocarcinoma: implications for targeted therapeutic strategies [0.03%]
胆管癌的分子机制和遗传特征及其对靶向治疗策略的意义
Xiao Lu,Shoujia Xu,Zhe Deng et al.
Xiao Lu et al.
Cholangiocarcinoma (CCA) is a biologically diverse and highly aggressive cancer that arises from the biliary epithelium. It is typically divided into intrahepatic, perihilar, and distal types, each with distinct clinical behavior, genetic a...
Bile acid metabolism and hcepatocellular carcinoma: mechanisms of drug resistance and intervention strategies [0.03%]
胆酸代谢与肝细胞癌：药物抗性的机制及干预策略
Yan Lu,Xiaochen Feng,Zhijie Wang et al.
Yan Lu et al.
Hepatocellular carcinoma (HCC) is the predominant malignant liver tumor, characterized by high morbidity, mortality, and rapid progression, and it ranks among the leading causes of cancer-related fatalities worldwide. Its treatment is facin...
Single-cell transcriptomic profiling reveals distinct tumor microenvironments in HPV-associated penile squamous cell carcinoma [0.03%]
单细胞转录组分析揭示了与HPV相关的阴茎鳞状细胞癌的不同肿瘤微环境
Lianbang Zhu,Deyun Shen,Jiahao Zhou et al.
Lianbang Zhu et al.
Background: Penile squamous cell carcinoma (PSCC) is a rare yet potentially lethal malignancy, often resulting in devastating disfigurement, with a 5-year survival rate of only ∼50%. Human papillomavirus (HPV) infection ...