Synthesis, molecular docking, pharmacological evaluation, MD simulation, and DFT calculations of quinazolin-12-one derivatives as PDK1 inhibitors [0.03%]
喹唑啉-12-一酮衍生物作为PDK1抑制剂的合成、分子对接、药理评价、MD模拟和DFT计算研究
Zahra Sadeghian,Mohammad Bayat,Davood Gheidari
Zahra Sadeghian
3-Phosphoinositide-dependent protein kinase-1(PDK1) is a vital kinase in cellular signaling that regulates growth and survival, playing a crucial role in cancer by activating Akt within the PI3K/Akt pathway. Elevated PDK1 levels correlate w...
A compartment-free digital plasmonic coupling assay via single-particle imaging and counting [0.03%]
基于单颗粒成像和计数的无隔室数字化等离激元耦合免疫检测法
Shengwei Zhang,Sina Jamalzadegan,Yan Wang et al.
Shengwei Zhang et al.
Plasmonic coupling-based biosensors have been conventionally quantified by bulk spectroscopic or color measurement methods. Such detection schemes limit assay sensitivity due to the high background noise of bulk measurement. In this work, w...
Decoration of gold nanoparticles with glycopeptides leads to a lower cellular uptake and liver retention [0.03%]
甘肽修饰的金纳米颗粒具有较低的细胞摄取和肝脏滞留性能
Mahmoud G Soliman,Jennifer Fernandez Alarcon,Tanja Ursula Lüdtke et al.
Mahmoud G Soliman et al.
Unspecific uptake by the liver is one of the main drawbacks of the translation of nanomaterials into clinics, preventing their delivery into diseased tissues. Here, we synthesized gold nanoparticles (GNPs) decorated with a sialic acid-displ...
A density functional theory investigation of ammonia oxidation pathways on nickel oxide [0.03%]
镍氧化物上氨氧化途径的密度泛函理论研究
Brendan D Paget,Shayne J Johnston,Henry Lim et al.
Brendan D Paget et al.
Direct ammonia fuel cells (DAFCs) utilize ammonia's chemical energy and convert it into electricity through the electrocatalyzed ammonia oxidation reaction (AOR). To date, studies have focused on Pt-based anode materials; however due to lim...
Evaluation of the safety profile of a metal-based nanosystem for developing antimicrobial polymer membranes in healthcare applications [0.03%]
一种金属基纳米系统的安全性评价及其在制备抗菌医用聚合物膜中的应用研究
Piumika Yapa,Imalka Munaweera,Mayuri Geethanjalie Thammitiyagodage
Piumika Yapa
Healthcare-associated infections remain a significant concern, driving the exploration of metal-based nanosystems as innovative solutions for developing antimicrobial polymer membranes. This study evaluates the toxicity of a novel nanofiber...
Bottom-up sono-enzymatic approach to build antimicrobial and antifouling nano-enabled coatings on urinary catheters [0.03%]
自下而上的声化学酶学法在导尿管表面构建抗菌抗污涂层
Antonio Puertas-Segura,Leonardo Martín Pérez,Paul Savage et al.
Antonio Puertas-Segura et al.
In this work, an antifouling and antibacterial nano-enabled coating for urinary catheters was synthesised using a bottom-up sono-enzymatic approach. Ceragenin CSA-131, an antimicrobial peptide, and lauryl gallate were nanoformulated into co...
Tuning the electrochemical performance of a hierarchical MoO3/CdO binary heterostructure for supercapacitor applications [0.03%]
用于超级电容器应用的分层MoO3 / CdO二元异质结构电化学性能的研究
Saifullah,Probal Roy,Md Abdullah Zubair et al.
Saifullah et al.
Cadmium oxide (CdO)-incorporating molybdenum trioxide (MoO3) nanocomposites were synthesized using a facile hydrothermal method by varying the CdO content (1%, 3%, and 5%) to comprehend the influence of CdO concentration on the electrochemi...
Copper ferrite-graphene oxide catalyst for enhanced peroxymonosulfate activation and pollutant degradation [0.03%]
用于增强过一硫酸盐活化和污染物降解的铜铁氧体-氧化石墨烯催化剂
Imane Sebah,Moustapha Belmouden
Imane Sebah
In this study, a magnetic nanocomposite of copper ferrite (CuFe2O4) supported on reduced graphene oxide (rGO) was synthesized via a solvothermal method and applied as a catalyst for the activation of peroxymonosulfate (PMS) to degrade Orang...
Biofilm formation on collagen substrates modulates Streptococcus mutans bacterial extracellular nanovesicle production and cargo [0.03%]
胶原底物上的菌斑形成调节变异链球菌细菌胞外纳米囊泡的产生及其负载货物
Camila Leiva-Sabadini,Pablo Berríos,Paula Saavedra et al.
Camila Leiva-Sabadini et al.
Streptococcus mutans is the major microbial etiological agent of dental caries and can adhere to surfaces such as type-I collagen, which is present in dentin and periodontal tissues. Recent studies have characterized planktonic S. mutans ba...
Semiconductor NbSe2 nanoparticles synthesized at various temperatures: a novel promising antifungal candidate with in vitro wound healing potential [0.03%]
在不同温度下合成的半导体NbSe2纳米颗粒：一种具有体外伤口愈合潜力的新型抗真菌候选药物
Shivani R Bharucha,Mehul S Dave,Sunil H Chaki et al.
Shivani R Bharucha et al.
This study reports the synthesis of niobium diselenide (NbSe2) nanoparticles at room temperature (RT), 70 °C, and 100 °C via a sonochemical method, followed by an assessment of their structural, morphological, antimicrobial, cytotoxic, an...