Subramanian Senthilkumaran,Ketan Patel,Elanchezhian Rajan et al.
Subramanian Senthilkumaran et al.
Envenomings by Russell's viper ( Daboia russelii ), a species of high medical importance in India and other Asian countries, commonly result in hemorrhage, coagulopathies, necrosis, and acute kidney injury. Although bleeding complications a...
Platelets and the Lectin Pathway of Complement Activation in Patients with Systemic Lupus Erythematosus or Antiphospholipid Syndrome [0.03%]
系统性红斑狼疮或抗磷脂综合征患者的血小板和补体 lect2 反应途径激活
Signe Risbøl Vils,Anne Troldborg,Anne-Mette Hvas et al.
Signe Risbøl Vils et al.
Background Patients with systemic lupus erythematosus (SLE) have an increased risk of thrombosis even when they do not have antiphospholipid syndrome (APS). Interactions between complement activation and activated platelets have been sugges...
Identification of High Platelet Reactivity Despite ADP P2Y 12 Inhibitor Treatment: Two Populations in the Vasodilator-Stimulated Phosphoprotein Assay and Variable PFA-P2Y Shapes of Curve [0.03%]
阿司匹林抵抗患者血小板高反应性的血管舒张素刺激磷酸化蛋白检测及不同PFA-P2Y曲线形状的临床意义：来自VSP试验的数据
Cyril Mariethoz,Emmanuelle Scala,Elena Matthey-Guirao et al.
Cyril Mariethoz et al.
Introduction Response to ADP P2Y 12 receptor inhibition by clopidogrel can be evaluated by various techniques. Here, we compared a functional rapid point-of-care technique (PFA-P2Y) with the degree of biochemical inhibition assessed by the ...
Geographical Variation in the Use of Oral Anticoagulation and Clinical Outcomes among Patients with Atrial Fibrillation in Denmark, Sweden, and Finland [0.03%]
丹麦、瑞典和芬兰心房颤动患者口服抗凝药使用率的地域差异及临床转归研究
Lars Frost,Olli Halminen,Mika Lehto et al.
Lars Frost et al.
Background Geographical mapping of variations in the treatment and outcomes of a disease is a valuable tool for identifying inequity. We examined international and intranational variations in initiating oral anticoagulation (OAC) therapy an...
John Raedts,Edwin Kellenbach
John Raedts
Heparin is typically extracted from domestic pigs, which may carry zoonotic adventitious agents. Prion and viral safety cannot be assured by testing the active pharmaceutical ingredient itself; instead for the evaluation of the adventitious...
Design of a Real-World Observational Study in Previously Untreated and Minimally Treated Hemophilia A Patients: Protect-NOW [0.03%]
未治疗及接受最少治疗的甲型血友病患者的现实世界观察性研究设计：保护 NOW 研究
Johannes Oldenburg,Susan Halimeh,Georgina W Hall et al.
Johannes Oldenburg et al.
Background The efficacy, safety, and immunogenicity of each of Octapharma's factor VIII (FVIII) products, Nuwiq, octanate, and wilate, have been investigated in previously untreated patients (PUPs) with severe hemophilia A in prospective cl...
Combination of Primary Hemostatic Disorders and Atrial Fibrillation Increases Bleeding Events Following Transcatheter Aortic Valve Replacement [0.03%]
原发性止血障碍和房颤在经导管主动脉瓣置换术后增加出血事件的风险
Kensuke Matsushita,Benjamin Marchandot,Marion Kibler et al.
Kensuke Matsushita et al.
Background Patients with atrial fibrillation (AF) are likely to have a poor prognosis including bleedings following transcatheter aortic valve replacement (TAVR). Closure time of adenosine diphosphate (CT-ADP) is a primary hemostasis point-...
Adjudicating the Diagnosis of Immune Thrombocytopenia in a Clinical Research Study [0.03%]
特发性血小板减少性紫癜的临床研究诊断标准探讨
Caroline Gabe,Syed Mahamad,Melanie St John et al.
Caroline Gabe et al.
Antithrombotic Effects of the Novel Small-Molecule Factor XIa Inhibitor Milvexian in a Rabbit Arteriovenous Shunt Model of Venous Thrombosis [0.03%]
新型小分子因子XIa抑制剂Milvexian的抗血栓作用：兔动静脉分流模型中的静脉血栓形成试验
Xinkang Wang,Qiu Li,Fuyong Du et al.
Xinkang Wang et al.
Background Factor XIa (FXIa) is an emerging therapeutic target, and FXIa inhibition is a promising mechanism to improve therapeutic index over current anticoagulants. Milvexian (BMS-986177/JNJ-70033093) is an oral small-molecule FXIa inhibi...
Guillaume Roberge,Carine Samson,Grégoire Le Gal et al.
Guillaume Roberge et al.
Background Intermittent fasting is becoming more popular as health benefits are described in recent literature. Various forms of fasting exist, one of them involving a zero-calorie diet and drinking only water. However, the safety of water-...