Exposure-Response Relationship between VWF/FVIII Activity and Spontaneous Bleeding Events Following Recombinant VWF Prophylaxis in Severe VWD [0.03%]
重组血管性假血友病因子预防治疗重度VWD患者自发性出血事件的发生与vWF/F VIII活性暴露反应关系的研究
Frank W G Leebeek,Giancarlo Castaman,Jean François Marier et al.
Frank W G Leebeek et al.
Background Recombinant von Willebrand factor (rVWF, vonicog alfa, Takeda Pharmaceuticals USA) is indicated in adults diagnosed with von Willebrand disease (VWD). In this study, the exposure-response (ER) relationship between VWF activity (V...
Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation [0.03%]
调控血小板不可逆激活的信号通路
Jinmi Zou,Siyu Sun,Ilaria De Simone et al.
Jinmi Zou et al.
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation. ...
Periprocedural Anticoagulation Management of Patients Undergoing Colonoscopy with Polypectomy [0.03%]
内镜黏膜下挖除术和内镜全层切除术后迟发性出血的风险因素分析
Melissa Chan,Joshua Yoon,Jennifer J Telford et al.
Melissa Chan et al.
Introduction/Objective Colonoscopy with polypectomy is an integral component of colorectal cancer screening. There are limited data and consensus on periprocedural anticoagulation management, especially regarding bleeding risk with uninterr...
Clinical Pathways and Outcomes of Andexanet Alfa Administration for the Reversal of Critical Bleeding in Patients on Oral Direct Factor Xa Inhibitors [0.03%]
Andexanet αfab用于口服直接因子Xa抑制剂患者危及生命的出血的临床路径和结局分析
Mark Goldin,Kolton Smith,Ioannis Koulas et al.
Mark Goldin et al.
Background Andexanet is U.S. Food and Drug Administration (FDA) approved for the reversal of critical bleeding from factor Xa inhibitors and off-label for surgical reversal. Data are lacking on andexanet administration processes. Methods We...
Management of Urgent Bleeding in Patients with Hemophilia A: Focus on the Use of Emicizumab [0.03%]
甲型血友病患者紧急出血的管理：emicizumab的应用聚焦
Víctor Jiménez-Yuste,María T Álvarez-Román,Rubén Berrueco et al.
Víctor Jiménez-Yuste et al.
Management of patients with hemophilia A (HA) requires the knowledge and experience of specialized health care professionals. However, these patients may need to be attended in emergencies, outside the referral hospital, where health care p...
Age-Dependent Detection of Atrial Fibrillation with Implantable Cardiac Monitors in Patients with Cryptogenic Stroke [0.03%]
不明原因卒中的植入式心脏监测仪在不同年龄段的心房颤动检出率
Tobias Uhe,Janina Keilitz,Jörg Berrouschot et al.
Tobias Uhe et al.
Background Continuous monitoring using implantable cardiac monitors (ICMs) results in atrial fibrillation (AF) detection rates of up to 30% in patients with cryptogenic stroke (CS). Although higher age is an independent risk factor for AF, ...
Disease Burden, Clinical Outcomes, and Quality of Life in People with Hemophilia A without Inhibitors in Europe: Analyses from CHESS II/CHESS PAEDs [0.03%]
CHESS II/CHESS PAEDs研究中的甲型血友病（无抑制物）患者的疾病负担、临床结局和生活质量分析
Pratima Chowdary,Richard Ofori-Asenso,Francis Nissen et al.
Pratima Chowdary et al.
Introduction Limited data relating to treatment burden, quality of life, and mental health burden of hemophilia A (HA) are currently available. Aim To provide a comprehensive overview of unmet needs in people with HA (PwHA) using data gener...
Thrombophilia Testing: from Genetic Predisposition to Discrimination [0.03%]
血栓形成倾向的检验：从基因易感性到区别对待政策
Andreas Verstraete,Kathleen Freson,Peter Verhamme et al.
Andreas Verstraete et al.
Challenges in the Monitoring of Therapeutic Plasma Exchange during Acute Heparin-Induced Thrombocytopenia in Adults under ECMO [0.03%]
成人体外膜氧合(ECMO)支持下的他莫西林诱导的血小板减少症(HTP)急性期治疗性血浆置换监测挑战
Nicolas Gendron,Candice Cavalie,Elie Kantor et al.
Nicolas Gendron et al.
Therapeutic plasma exchange (TPE) has been proposed to remove heparin-induced thrombocytopenia (HIT) antibodies before planned thoracic surgery in patients with acute HIT and to allow brief re-exposure to heparin during surgery. In patients...
Impaired Whole-Blood Fibrinolysis is a Predictor of Mortality in Intensive Care Patients [0.03%]
重症监护患者的全血纤溶功能受损是死亡率的预测指标
Julie S Brewer,Christine L Hvas,Anne-Mette Hvas et al.
Julie S Brewer et al.
Background Altered fibrinolysis is considered to play a crucial role in the development of coagulopathy in sepsis. However, routine laboratory tests for fibrinolysis are currently very limited, and the impact of fibrinolytic capacity on cli...