An Intestinal Microbiome Intervention Affects Biochemical Disease Activity in Patients with Antiphospholipid Syndrome [0.03%]
肠道微生物组干预影响抗磷脂综合征患者生化疾病活动度
Valérie L B I Jansen,Dagmar J M van Mourik,Mark Davids et al.
Valérie L B I Jansen et al.
Background The origin of autoantibodies in patients with antiphospholipid syndrome (APS) is unknown. The gut microbiome contributes to autoimmunity and contains peptide homologues to the main APS autoantigen, which affect disease activity i...
Corrigendum: Bleeding Risk Prediction in Patients Treated with Antithrombotic Drugs According to the Anatomic Site of Bleeding, Indication for Treatment, and Time Since Treatment Initiation [0.03%]
特发部位、治疗适应证及开始用药时间指导下的抗栓药使用者出血风险预测的订正公告
Vinai Bhagirath,Tanya Kovalova,Jia Wang et al.
Vinai Bhagirath et al.
[This corrects the article DOI: 10.1055/a-2259-1134.]. The Author(s). This is an open access article published by Thieme under the terms of the Creative ...
Establishing Expectancy Values for Fibrin Monomer in Uncomplicated Pregnancy [0.03%]
建立未并发症妊娠纤维蛋白单体的预期值
Holger Seidel,Melina Duncklenberg,Hans-Jörg Hertfelder et al.
Holger Seidel et al.
Background During pregnancy, a physiological increase of molecular activation markers (MAM) of hemostasis such as prothrombin fragments 1 + 2, thrombin-antithrombin complex, and D-dimers (DD) occurs. Therefore, monitoring MAM levels during ...
Use of Magnetic Resonance Direct Thrombus Imaging for the Diagnostic Management of Suspected Thrombosis in Routine Clinical Practice [0.03%]
磁共振直接血栓成像在日常医疗实践中的应用：疑似血栓患者诊断治疗课题研究
Cindy M M de Jong,Lisette F van Dam,Charlotte E A Dronkers et al.
Cindy M M de Jong et al.
Background The noninvasive magnetic resonance direct thrombus imaging (MRDTI) technique can be used to diagnose acute deep vein thrombosis (DVT), without the use of intravenous contrast. MRDTI holds the potential to differentiate between ac...
Epidemiology, Treatment Patterns, and Cost Analysis of Immune Thrombocytopenia in Spain between 2014 and 2020: A Population-based Study [0.03%]
2014年至2020年期间西班牙免疫性血小板减少症的流行病学、治疗模式和成本分析：一项基于人群的研究
Tomás J González-López,Gabriela Alperovich,Elena Burillo et al.
Tomás J González-López et al.
Background Immune thrombocytopenia (ITP) is characterised by low platelet counts and often leads to bleeding, fatigue, and reduced health-related quality of life. Methods This observational, retrospective, population-based study using BIG-P...
Reduced Volume and Faster Infusion Rate of Activated Prothrombin Complex Concentrate: A Phase 3b/4 Trial in Adults with Hemophilia A with Inhibitors [0.03%]
体积更小且输注速度更快的活化凝血酶原复合浓缩剂：A型血友病伴抑制物成人的3b/4期临床试验
Bülent Zülfikar,Johnny Mahlangu,Salim Mohamed Nekkal et al.
Bülent Zülfikar et al.
Background Activated prothrombin complex concentrate (aPCC) is indicated for bleed treatment and prevention in patients with hemophilia with inhibitors. The safety and tolerability of intravenous aPCC at a reduced volume and faster infusion...
Exposure-Response Relationship between VWF/FVIII Activity and Spontaneous Bleeding Events Following Recombinant VWF Prophylaxis in Severe VWD [0.03%]
重组血管性假血友病因子预防治疗重度VWD患者自发性出血事件的发生与vWF/F VIII活性暴露反应关系的研究
Frank W G Leebeek,Giancarlo Castaman,Jean François Marier et al.
Frank W G Leebeek et al.
Background Recombinant von Willebrand factor (rVWF, vonicog alfa, Takeda Pharmaceuticals USA) is indicated in adults diagnosed with von Willebrand disease (VWD). In this study, the exposure-response (ER) relationship between VWF activity (V...
Platelet Activation Pathways Controlling Reversible Integrin αIIbβ3 Activation [0.03%]
调控血小板不可逆激活的信号通路
Jinmi Zou,Siyu Sun,Ilaria De Simone et al.
Jinmi Zou et al.
Background Agonist-induced platelet activation, with the integrin αIIbβ3 conformational change, is required for fibrinogen binding. This is considered reversible under specific conditions, allowing a second phase of platelet aggregation. ...
Periprocedural Anticoagulation Management of Patients Undergoing Colonoscopy with Polypectomy [0.03%]
内镜黏膜下挖除术和内镜全层切除术后迟发性出血的风险因素分析
Melissa Chan,Joshua Yoon,Jennifer J Telford et al.
Melissa Chan et al.
Introduction/Objective Colonoscopy with polypectomy is an integral component of colorectal cancer screening. There are limited data and consensus on periprocedural anticoagulation management, especially regarding bleeding risk with uninterr...
Clinical Pathways and Outcomes of Andexanet Alfa Administration for the Reversal of Critical Bleeding in Patients on Oral Direct Factor Xa Inhibitors [0.03%]
Andexanet αfab用于口服直接因子Xa抑制剂患者危及生命的出血的临床路径和结局分析
Mark Goldin,Kolton Smith,Ioannis Koulas et al.
Mark Goldin et al.
Background Andexanet is U.S. Food and Drug Administration (FDA) approved for the reversal of critical bleeding from factor Xa inhibitors and off-label for surgical reversal. Data are lacking on andexanet administration processes. Methods We...