Effectiveness and Safety of Rivaroxaban Versus Warfarin among Nonvalvular Atrial Fibrillation Patients with Concomitant Obstructive Sleep Apnea [0.03%]
非瓣膜性房颤且伴有睡眠呼吸暂停症患者的利伐沙班与华法林的对比研究：效果和安全性
Nitesh Sood,Veronica Ashton,Youssef Bessada et al.
Nitesh Sood et al.
Background Obstructive sleep apnea (OSA) is associated with an increased incidence of atrial fibrillation (AF), hypertension, diabetes, heart failure, coronary heart disease, stroke, and death. We sought to evaluate the effectiveness and sa...
Sepsis-Associated DIC with Decreased Levels of Antithrombin and Fibrinogen is the Target for Combination Therapy with Thrombomodulin Alfa and Antithrombin [0.03%]
降抗凝血酶和纤维蛋白原水平的脓毒症相关性DIC是重组水溶性 thrombomodulin与抗凝血酶联合治疗的目标类型
Hideo Wada,Kazuo Kawasugi,Goichi Honda et al.
Hideo Wada et al.
Background Disseminated intravascular coagulation (DIC) is not a homogeneous condition, but rather includes heterogeneous conditions, and its pathophysiology and outcome vary considerably depending on the background. Although anticoagulant ...
Automated Light Transmission Aggregometry with and without Platelet Poor Plasma Reference: A Method Comparison [0.03%]
自动化光透射聚集测定法有和无血小板减少血浆参考：一种方法比较
Ulrich J Sachs,Lida Röder,Nina Cooper et al.
Ulrich J Sachs et al.
Background Light transmission aggregometry (LTA) is considered the gold standard for the evaluation of platelet function but is labor-intensive and involves numerous manual steps. Automation may contribute to standardization. Here, we evalu...
Treatment of Acquired von Willebrand Disease due to Extracorporeal Membrane Oxygenation in a Pediatric COVID-19 Patient with Vonicog Alfa: A Case Report and Literature Review [0.03%]
儿科新冠患者体外膜肺氧合所致获得性血管性血友病的治疗——用Vonicog Alfa药物治疗一例报道及文献回顾
Lars Heubner,Karolin Trautmann-Grill,Oliver Tiebel et al.
Lars Heubner et al.
Acquired von Willebrand disease (aVWD) is frequently observed in patients with the need for extracorporeal membrane oxygenation (ECMO). aVWD can be treated by plasma-derived concentrates containing factor VIII (FVIII) and/or von Willebrand ...
In vitro Effect of Dalteparin and Argatroban on Hemostasis in Critically Ill Sepsis Patients with New-Onset Thrombocytopenia [0.03%]
达肝素和阿加曲班对脓毒症合并新发血小板减少的危重患者体外凝血功能的影响
Søren Nygaard,Christine L Hvas,Anne-Mette Hvas et al.
Søren Nygaard et al.
Thrombocytopenia is common among critically ill sepsis patients, while they also hold an increased risk for thromboembolic events. Thus, the choice of anticoagulant prophylaxis for this patient population is challenging. We investigated the...
Analysis of 363 Genetic Variants in F5 via an Interactive Web Database Reveals New Insights into FV Deficiency and FV Leiden [0.03%]
通过交互式网络数据库分析F5的363种基因变异，揭示了新的FV缺乏和FV莱顿突变见解
Christos Efthymiou,Emily H T Print,Anna Simmons et al.
Christos Efthymiou et al.
The inherited bleeding disorder Factor V (FV) deficiency and clotting risk factor FV Leiden are associated with genetic variants in the F5 gene. FV deficiency occurs with mild, moderate, severe, or asymptomatic phenotypes, and either dysfun...
The Saudi Consensus for the Management of Cancer-Associated Thromboembolism: A Modified Delphi-Based Study [0.03%]
沙特癌症相关血栓症管理共识：一项改良德尔菲法研究
Mohammed Alsheef,Shouki Bazarbashi,Ashraf Warsi et al.
Mohammed Alsheef et al.
Background Cancer is a well-known risk factor of preventable thromboembolic disease. This study aims to provide guidance on the prevention and management of cancer-associated thrombosis (CT) that tailors prophylactic and therapeutic options...
Edoxaban, a Factor Xa-Specific Direct Oral Anticoagulant, Significantly Suppresses Tumor Growth in Colorectal Cancer Colon26-Inoculated BALB/c Mice [0.03%]
一种新型的口服直接Xa因子特异性抗凝剂艾多沙班抑制结肠癌CT26细胞小鼠移植瘤生长作用的研究
Keiichi Hiramoto,Nobuyuki Akita,Junji Nishioka et al.
Keiichi Hiramoto et al.
Introduction Certain low-molecular-weight heparins have been reported to reduce tumor growth and metastasis in tumor cell-inoculated mouse models and cancer patients. Recently, direct oral anticoagulants (DOACs) have been widely used in pat...
Evaluation of Risk Scores as Predictive Tools for Stroke in Patients with Retinal Artery Occlusion: A Danish Nationwide Cohort Study [0.03%]
风险评分作为视网膜动脉阻塞患者中风预测工具的评估：一项丹麦全国性队列研究
Marie Ørskov,Henrik Vorum,Torben Bjerregaard Larsen et al.
Marie Ørskov et al.
Purpose We investigated the 1-year risk of stroke in patients with retinal artery occlusion and evaluated the predictive and discriminating abilities of contemporary risk stratification models for embolic stroke. Methods This register-based...
Physical Characteristics of von Willebrand Factor Binding with Platelet Glycoprotein Ibɑ Mutants at Residue 233 Causing Various Biological Functions [0.03%]
血小板膜糖蛋白Ibɑ第233位点突变与血管性假血友病因子结合特性的改变及不同生物学功能的关系研究
Masamitsu Nakayama,Shinichi Goto,Shinya Goto
Masamitsu Nakayama
Glycoprotein (GP: HIS 1 -PRO 265 ) Ibɑ is a receptor protein expressed on the surface of the platelet. Its N-terminus domain binds with the A1 domain (ASP 1269 -PRO 1472 ) of its ligand protein von Willebrand factor (VWF) and plays a uniqu...