Dorsal Finger Fold Recognition by Convolutional Neural Networks for the Detection and Monitoring of Joint Swelling in Patients with Rheumatoid Arthritis [0.03%]
基于卷积神经网络的指褶纹识别在类风湿关节炎患者肿胀关节检测和监测中的应用研究
Thomas Hügle,Leo Caratsch,Matteo Caorsi et al.
Thomas Hügle et al.
Digital biomarkers such as wearables are of increasing interest in monitoring rheumatic diseases, but they usually lack disease specificity. In this study, we apply convolutional neural networks (CNN) to real-world hand photographs in order...
Quantifying the Benefits of Digital Biomarkers and Technology-Based Study Endpoints in Clinical Trials: Project Moneyball [0.03%]
量化数字生物标志物及基于技术的临床试验研究终点的优势：Moneyball项目
Hiromasa Mori,Stig Johan Wiklund,Jason Yuren Zhang
Hiromasa Mori
Introduction: Digital biomarkers have significant potential to transform drug development, but only a few have contributed meaningfully to bring new treatments to market. There are uncertainties in how they will generate ...
Considerations for Conducting Bring Your Own "Device" (BYOD) Clinical Studies [0.03%]
开展“自带设备”（BYOD）临床试验的考量因素
Charmaine Demanuele,Cynthia Lokker,Krishna Jhaveri et al.
Charmaine Demanuele et al.
Background: Digital health technologies are attracting attention as novel tools for data collection in clinical research. They present alternative methods compared to in-clinic data collection, which often yields snapshot...
Video-Based Pose Estimation for Gait Analysis in Stroke Survivors during Clinical Assessments: A Proof-of-Concept Study [0.03%]
基于视频的姿势估计在临床评估中用于卒中患者的步态分析的概念验证研究
Luca Lonini,Yaejin Moon,Kyle Embry et al.
Luca Lonini et al.
Recent advancements in deep learning have produced significant progress in markerless human pose estimation, making it possible to estimate human kinematics from single camera videos without the need for reflective markers and specialized l...
A Smartphone Application as an Exploratory Endpoint in a Phase 3 Parkinson's Disease Clinical Trial: A Pilot Study [0.03%]
帕金森病三期临床试验中手机应用程序的探索性研究终点：一项试点研究
Alex Page,Norman Yung,Peggy Auinger et al.
Alex Page et al.
Background: Smartphones can generate objective measures of Parkinson's disease (PD) and supplement traditional in-person rating scales. However, smartphone use in clinical trials has been limited. ...
[This corrects the article DOI: 10.1159/000512500.]. Copyright © 2021 by S. Karger AG, Basel.
Published Erratum
Digital biomarkers. 2021 Nov 25;5(3):224. DOI:10.1159/000520738 2021
First Regulatory Qualification of a Novel Digital Endpoint in Duchenne Muscular Dystrophy: A Multi-Stakeholder Perspective on the Impact for Patients and for Drug Development in Neuromuscular Diseases [0.03%]
杜兴氏肌肉营养不良新型数字终点首次监管认定：多利益相关方视角对神经肌肉疾病患者及药物研发的影响
Laurent Servais,Eric Camino,Aude Clement et al.
Laurent Servais et al.
Background: Functional outcome measures used to assess efficacy in clinical trials of investigational treatments for rare neuromuscular diseases like Duchenne muscular dystrophy (DMD) are performance-based tasks completed...
Beyond the Therapist's Office: Merging Measurement-Based Care and Digital Medicine in the Real World [0.03%]
超越治疗室：在现实世界中结合基于测量的护理和数字医疗
Emil Chiauzzi,Paul Wicks
Emil Chiauzzi
This viewpoint focuses on the ways in which digital medicine and measurement-based care can be utilized in tandem to promote better assessment, patient engagement, and an improved quality of psychiatric care. To date, there has been an unde...
Advanced Machine Learning Tools to Monitor Biomarkers of Dysphagia: A Wearable Sensor Proof-of-Concept Study [0.03%]
高级机器学习工具监测吞咽障碍生物标志物：可穿戴传感器的概念验证研究
Megan K O&#x;Brien,Olivia K Botonis,Elissa Larkin et al.
Megan K O&#x;Brien et al.
Introduction: Difficulty swallowing (dysphagia) occurs frequently in patients with neurological disorders and can lead to aspiration, choking, and malnutrition. Dysphagia is typically diagnosed using costly, invasive imag...
Digital Endpoints: Definition, Benefits, and Current Barriers in Accelerating Development and Adoption [0.03%]
数字终点：定义、益处及目前在加速发展和采纳方面遇到的障碍
Matthew Landers,Ray Dorsey,Suchi Saria
Matthew Landers
The assessment of health and disease requires a set of criteria to define health status and progression. These health measures are referred to as "endpoints." A "digital endpoint" is defined by its use of sensor-generated data often collect...