Validation of an Automated Speech Analysis of Cognitive Tasks within a Semiautomated Phone Assessment [0.03%]
认知任务的自动语音分析的验证工作——在半自动化电话评估中
Daphne Ter Huurne,Nina Possemis,Leonie Banning et al.
Daphne Ter Huurne et al.
Introduction: We studied the accuracy of the automatic speech recognition (ASR) software by comparing ASR scores with manual scores from a verbal learning test (VLT) and a semantic verbal fluency (SVF) task in a semiautom...
The Case for the Patient-Centric Development of Novel Digital Sleep Assessment Tools in Major Depressive Disorder [0.03%]
抑郁症患者中心的新型数字睡眠评估工具开发案例
Nele Peerenboom,Suvekshya Aryal,Jennifer M Blankenship et al.
Nele Peerenboom et al.
Background: Depression imposes a major burden on public health as the leading cause of disability worldwide. Sleep disturbance is a core symptom of depression that affects the vast majority of patients. Nonetheless, it is...
Exploring the Potential of Apple SensorKit and Digital Phenotyping Data as New Digital Biomarkers for Mental Health Research [0.03%]
探索Apple SensorKit和数字表型数据作为心理健康研究中新数字生物标志物的潜力
Carsten Langholm,Tobias Kowatsch,Sandra Bucci et al.
Carsten Langholm et al.
The use of digital phenotyping continues to expand across all fields of health. By collecting quantitative data in real-time using devices such as smartphones or smartwatches, researchers and clinicians can develop a profile of a wide range...
Regulatory Qualification of a Cross-Disease Digital Measure: Benefits and Challenges from the Perspective of IMI Consortium IDEA-FAST [0.03%]
IMI项目IDEA-FAST联合体关于跨疾病数字测量监管资质的利与弊的观点
David Nobbs,Wojciech Piwko,Christopher Bull et al.
David Nobbs et al.
Background: Innovative Medicines Initiative (IMI) consortium IDEA-FAST is developing novel digital measures of fatigue, sleep quality, and impact of sleep disturbances for neurodegenerative diseases and immune-mediated in...
Automated Real-World Video Analysis of Sit-to-Stand Transitions Predicts Parkinson's Disease Severity [0.03%]
自动化的真实世界视频分析坐立过渡预测帕金森病的严重程度
Catherine Morgan,Alessandro Masullo,Majid Mirmehdi et al.
Catherine Morgan et al.
Introduction: Technology holds the potential to track disease progression and response to neuroprotective therapies in Parkinson's disease (PD). The sit-to-stand (STS) transition is a frequently occurring event which is i...
Clinical Validation of Novel Digital Measures: Statistical Methods for Reliability Evaluation [0.03%]
新型数字测量的临床验证：可靠性评价的统计方法
Bohdana Ratitch,Andrew Trigg,Madhurima Majumder et al.
Bohdana Ratitch et al.
Background: Assessment of reliability is one of the key components of the validation process designed to demonstrate that a novel clinical measure assessed by a digital health technology tool is fit-for-purpose in clinica...
Development and Assessment of an Artificial Intelligence-Based Tool for Ptosis Measurement in Adult Myasthenia Gravis Patients Using Selfie Video Clips Recorded on Smartphones [0.03%]
基于人工智能的眼睑下垂测量工具的开发和评估用于成人重症肌无力患者的自拍视频片段录制在智能手机上
Meelis Lootus,Lulu Beatson,Lucas Atwood et al.
Meelis Lootus et al.
Introduction: Myasthenia gravis (MG) is a rare autoimmune disease characterized by muscle weakness and fatigue. Ptosis (eyelid drooping) occurs due to fatigue of the muscles for eyelid elevation and is one symptom widely ...
How Much Evidence Is Enough? Research Sponsor Experiences Seeking Regulatory Acceptance of Digital Health Technology-Derived Endpoints [0.03%]
足够的证据有多少？寻求监管部门认可基于数字健康技术的终点的研究资助者经验
Brian Perry,Lindsay Kehoe,Teresa Swezey et al.
Brian Perry et al.
Introduction: Digital health technologies (DHTs) provide opportunities for real-time data collection and assessment of patient function. However, use of DHT-derived endpoints in clinical trials to support medical product ...
Using Clinical Scales and Digital Measures to Explore Falls in Patients with Lewy Body Dementia [0.03%]
利用临床量表和数字测量探索莱ysz体痴呆患者的跌倒问题
Chakib Battioui,Albert Man,Melissa Pugh et al.
Chakib Battioui et al.
Introduction: PRESENCE was a phase 2 clinical trial assessing the efficacy of mevidalen, a D1 receptor positive allosteric modulator, for symptomatic treatment of Lewy body dementia (LBD). Mevidalen demonstrated improveme...
Reverse Engineering of Digital Measures: Inviting Patients to the Conversation [0.03%]
数字化评价的逆向工程——邀请患者参与对话
Ieuan Clay,Nele Peerenboom,Dana E Connors et al.
Ieuan Clay et al.
Background: Digital measures offer an unparalleled opportunity to create a more holistic picture of how people who are patients behave in their real-world environments, thereby establishing a better connection between pat...