Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age [0.03%]
与疲劳相关的日常功能变化：数字时代最有前景的措施
Walter Maetzler,Leonor Correia Guedes,Kirsten Nele Emmert et al.
Walter Maetzler et al.
Background: Fatigue is a prominent symptom in many diseases and is strongly associated with impaired daily function. The measurement of daily function is currently almost always done with questionnaires, which are subject...
Deep Learning-Based Psoriasis Assessment: Harnessing Clinical Trial Imaging for Accurate Psoriasis Area Severity Index Prediction [0.03%]
基于深度学习的银屑病评估：利用临床试验图像准确预测银屑病面积严重指数
Yunzhao Xing,Sheng Zhong,Samuel L Aronson et al.
Yunzhao Xing et al.
Introduction: Image-based machine learning holds great promise for facilitating clinical care; however, the datasets often used for model training differ from the interventional clinical trial-based findings frequently us...
Why Language Matters in Digital Endpoint Development: Harmonized Terminology as a Key Prerequisite for Evidence Generation [0.03%]
语言在数字终端开发中的重要性：和谐的术语是生成证据的关键前提条件
Lada Leyens,Carrie A Northcott,Lesley Maloney et al.
Lada Leyens et al.
Background: Developments in the field of digital measures and digitally derived endpoints demand greater attention on globally aligned approaches to enhance digital measure acceptance by regulatory authorities and health ...
How Much Speech Data Is Needed for Tracking Language Change in Alzheimer's Disease? A Comparison of Random Length, 5-Min, and 1-Min Spontaneous Speech Samples [0.03%]
阿尔茨海默病语言变化跟踪所需言语数据量是多少？随机长度、五分钟和一分钟自发言语样本的比较研究
Ulla Petti,Simon Baker,Anna Korhonen et al.
Ulla Petti et al.
Introduction: Changes in speech can act as biomarkers of cognitive decline in Alzheimer's disease (AD). While shorter speech samples would promote data collection and analysis, the minimum length of informative speech sam...
Development of a Prototype Video Head Impulse Test System Using an iPhone for Screening of Peripheral Vestibular Dysfunction [0.03%]
利用iPhone开发前庭视频头脉冲检测系统原型用于外周前庭功能障碍筛查
Tatsuaki Kuroda,Kazuhiro Kuroda,Hiroaki Fushiki
Tatsuaki Kuroda
Introduction: Head impulse, nystagmus, and test of skew (HINTS) is more accurate for the early diagnosis of occipital fossa stroke than magnetic resonance imaging. However, the head impulse test (HIT) is relatively challe...
Usability and Acceptability of a Corneal-Plane α-Opic Light Logger in a 24-h Field Trial [0.03%]
基于角膜平面的α-opic光照强度记录仪24小时现场试验的适用性和可接受性
Eljoh Balajadia,Sophie Garcia,Janine Stampfli et al.
Eljoh Balajadia et al.
Introduction: Exposure to light fundamentally influences human physiology and behaviour by synchronising our biological clock to the external light-dark cycle and controlling melatonin production. In addition to well-cont...
Validation of an Automated Speech Analysis of Cognitive Tasks within a Semiautomated Phone Assessment [0.03%]
认知任务的自动语音分析的验证工作——在半自动化电话评估中
Daphne Ter Huurne,Nina Possemis,Leonie Banning et al.
Daphne Ter Huurne et al.
Introduction: We studied the accuracy of the automatic speech recognition (ASR) software by comparing ASR scores with manual scores from a verbal learning test (VLT) and a semantic verbal fluency (SVF) task in a semiautom...
The Case for the Patient-Centric Development of Novel Digital Sleep Assessment Tools in Major Depressive Disorder [0.03%]
抑郁症患者中心的新型数字睡眠评估工具开发案例
Nele Peerenboom,Suvekshya Aryal,Jennifer M Blankenship et al.
Nele Peerenboom et al.
Background: Depression imposes a major burden on public health as the leading cause of disability worldwide. Sleep disturbance is a core symptom of depression that affects the vast majority of patients. Nonetheless, it is...
Exploring the Potential of Apple SensorKit and Digital Phenotyping Data as New Digital Biomarkers for Mental Health Research [0.03%]
探索Apple SensorKit和数字表型数据作为心理健康研究中新数字生物标志物的潜力
Carsten Langholm,Tobias Kowatsch,Sandra Bucci et al.
Carsten Langholm et al.
The use of digital phenotyping continues to expand across all fields of health. By collecting quantitative data in real-time using devices such as smartphones or smartwatches, researchers and clinicians can develop a profile of a wide range...
Regulatory Qualification of a Cross-Disease Digital Measure: Benefits and Challenges from the Perspective of IMI Consortium IDEA-FAST [0.03%]
IMI项目IDEA-FAST联合体关于跨疾病数字测量监管资质的利与弊的观点
David Nobbs,Wojciech Piwko,Christopher Bull et al.
David Nobbs et al.
Background: Innovative Medicines Initiative (IMI) consortium IDEA-FAST is developing novel digital measures of fatigue, sleep quality, and impact of sleep disturbances for neurodegenerative diseases and immune-mediated in...