Visualization of OPN-Targeted Self-Assembled Micelles Encapsulated With an SIRT6 Activator and Doped Indocyanine Green for Attenuating Vascular Aging [0.03%]
可视化OPN靶向自组装聚合物胶束递送SIRT6激活剂和吲哚菁绿联合治疗血管衰老
Yan Fang,Wenyue Li,Cheng Qin et al.
Yan Fang et al.
Objectives: Sirtuin 6 (SIRT6) is a longevity-associated gene with recognized therapeutic potential for vascular aging through the regulation of vascular smooth muscle cells (VSMCs) senescence. This study aims to develop a...
Mental Health and Aging: Identifying Risk and Protective Factors of Anxiety and Depression in Older Women [0.03%]
老年女性焦虑和抑郁的风险和保护因素识别：心理健康与老龄化
Guilherme Augusto Santos Bueno,Renato Canevari Dutra da Silva,Elton Brás Camargo Júnior et al.
Guilherme Augusto Santos Bueno et al.
Objective: To identify risk and protective factors associated with anxiety and depression symptoms in older adult women, considering clinical, functional, and electrophysiological parameters. ...
Generation of Nonintegrative-Induced Pluripotent Stem Cells in Hutchinson-Gilford Progeria Syndrome: Enhancing Aging Research [0.03%]
Hutchinson-Gilford早衰综合征的非整合诱导多能干细胞的生成及在抗衰老研究中的应用增强作用
Juned Kadiwala,Rameen Shakur
Juned Kadiwala
Heart failure and cardiovascular disease are the primary causes of mortality in patients with Hutchinson-Gilford Progeria Syndrome (HGPS), resulting from mutations in the LMNA gene. In this study, we investigated a familial pedigree of HGPS...
Artificial Intelligence in Medication Management for Older Adults in Low- and Middle-Income Countries: A Narrative Review [0.03%]
低收入和中等收入国家老年人用药管理的人工智能技术：叙述性评论
Christina Malini Christopher,Nabin Pathak,Zaheer-Ud-Din Babar et al.
Christina Malini Christopher et al.
Artificial Intelligence (AI) has emerged as a transformative tool in medication management, particularly for older adults who are vulnerable to adverse drug events, polypharmacy, and medication non-adherence. This narrative review explores ...
Wan-Zhou Wu,Xuan Wang,Fang-Fang Wu et al.
Wan-Zhou Wu et al.
As we approach the mid-21st century, more developing countries are progressing towards becoming developed nations. Advances in medical technology have resulted in the prolonged human lifespan and a sustained decline in birth rates, leading ...
A Novel Theoretical Hypothesis on Comorbidity in the Elderly-The Disease of Sympathetic Overdrive (DSO) [0.03%]
关于老年人并存疾病的新假设—— sympathetic overdrive 病毒理论
Li Jie,Kong Jian,Yu Boxin et al.
Li Jie et al.
The coexistence of multimorbidity and geriatric syndromes is a big character and role target to manage for the clinic works in older age, but related theories still require innovation and exploration. The disease of sympathetic overdrive (D...
Association Between Turn Impairments and Cognitive Function in Parkinson Disease [0.03%]
帕金森病患者转身障碍与认知功能的关系
Shanhu Xu,Linlin Kong,Xiaoli Liu et al.
Shanhu Xu et al.
Objective: To investigate the association of turn parameters with cognitive status in patients with Parkinson disease (PD) and determine the value of turn performance in distinguishing PD-related cognitive impairment (CI)...
Potentially Inappropriate Medications and Drug-Drug Interactions in Geriatrics Cardiac Patients Visiting to Tertiary Care Central Hospital of Nepal [0.03%]
尼泊尔三级医疗中心就诊的老年心脏病患者不适当药物使用及药物相互作用的调查研究
Roshan Giri,Rajeev Shrestha,Aatma Rai et al.
Roshan Giri et al.
Objective: Potentially Inappropriate Medications (PIMs) and Drug-Drug Interactions (DDIs) among geriatrics are a prominent issue and place a considerable burden on the quality health outcome. This study aimed to assess PI...
Spino-Pelvic Alignment and Surgical Outcomes in Chinese Elderly With Lumbar Stenosis Syndrome: A Prospective Study [0.03%]
腰骶骨盆排列与腰椎管狭窄症老年人手术效果的相关性研究：一项前瞻性研究
Chong Zhao,Linyu Jin,Yan Liang et al.
Chong Zhao et al.
Objective: This study aimed to systematically identify and quantify the acceptable spino-pelvic parameters for Chinese elderly patients with lumbar stenosis syndrome (LSS) following surgical treatment. ...
Impact of Type 2 Diabetes Mellitus and Chronic Kidney Disease on Bone Mineral Density in Elderly Patients With Fragility Hip Fracture: A Cross-Sectional Study [0.03%]
2型糖尿病和慢性肾脏病对脆弱性髋部骨折老年人骨密度影响：一项横断面研究
Debajyoti Roy,Jiashen Cai,Chee Yong Ng et al.
Debajyoti Roy et al.
Objectives: Diabetes mellitus (DM) and chronic kidney disease (CKD) are prevalent conditions in the elderly population, increasing the risk of bone fractures due to their adverse effects on bone quality. This study aimed ...