Simulating Time-Dependent Patterns of Nonadherence by Patients With Breast Cancer to Adjuvant Oral Endocrine Therapy [0.03%]
乳腺癌患者对辅助口服内分泌治疗不依从的时变模式模拟研究
Eileen H Shinn,Gordon Broderick,Bryan Fellman et al.
Eileen H Shinn et al.
Purpose: Nearly 40% of patients with breast cancer discontinue their adjuvant oral endocrine treatment (ET). We measured discontinuation rates of ET at a comprehensive cancer center. We then used an iterative approach to ...
Natural Language Processing for Automated Quantification of Brain Metastases Reported in Free-Text Radiology Reports [0.03%]
基于自由文本放射学报告的自然语言处理在脑转移瘤量化中的应用
Joeky T Senders,Aditya V Karhade,David J Cote et al.
Joeky T Senders et al.
Purpose: Although the bulk of patient-generated health data are increasing exponentially, their use is impeded because most data come in unstructured format, namely as free-text clinical reports. A variety of natural lang...
A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic [0.03%]
一项用于优化个性化网络模型临床转化的机器学习平台
Manuela Salvucci,Arman Rahman,Alexa J Resler et al.
Manuela Salvucci et al.
Purpose: Dynamic network models predict clinical prognosis and inform therapeutic intervention by elucidating disease-driven aberrations at the systems level. However, the personalization of model predictions requires the...
Leveraging Single-Cell RNA Sequencing Experiments to Model Intratumor Heterogeneity [0.03%]
利用单细胞RNA测序实验建模肿瘤内异质性
Meghan C Ferrall-Fairbanks,Markus Ball,Eric Padron et al.
Meghan C Ferrall-Fairbanks et al.
Purpose: Many cancers can be treated with targeted therapy. Almost inevitably, tumors develop resistance to targeted therapy, either from pre-existence or by evolving new genotypes and traits. Intratumor heterogeneity ser...
Hospitalization Risk During Chemotherapy for Advanced Cancer: Development and Validation of Risk Stratification Models Using Real-World Data [0.03%]
基于真实世界数据的晚期癌症化疗住院风险分层模型的建立及验证
Gabriel A Brooks,Hajime Uno,Erin J Aiello Bowles et al.
Gabriel A Brooks et al.
Purpose: Hospitalizations are a common occurrence during chemotherapy for advanced cancer. Validated risk stratification tools could facilitate proactive approaches for reducing hospitalizations by identifying at-risk pat...
HistoQC: An Open-Source Quality Control Tool for Digital Pathology Slides [0.03%]
HistoQC：一种用于数字病理切片的开源质量控制工具
Andrew Janowczyk,Ren Zuo,Hannah Gilmore et al.
Andrew Janowczyk et al.
Purpose: Digital pathology (DP), referring to the digitization of tissue slides, is beginning to change the landscape of clinical diagnostic workflows and has engendered active research within the area of computational pa...
Mathematical Approach to Differentiate Spontaneous and Induced Evolution to Drug Resistance During Cancer Treatment [0.03%]
数学方法区分癌症治疗期间药物耐药性的自发和诱发进化
James M Greene,Jana L Gevertz,Eduardo D Sontag
James M Greene
Purpose: Drug resistance is a major impediment to the success of cancer treatment. Resistance is typically thought to arise from random genetic mutations, after which mutated cells expand via Darwinian selection. However,...
Juan Carlos López Alfonso,Jan Poleszczuk,Rachel Walker et al.
Juan Carlos López Alfonso et al.
Purpose: Early-stage cancers are routinely treated with surgery followed by radiotherapy (SR). Radiotherapy before surgery (RS) has been widely ignored for some cancers. We evaluate overall survival (OS) and disease-free ...
Stochastic Evolution of Pancreatic Cancer Metastases During Logistic Clonal Expansion [0.03%]
逻辑克隆扩张下的胰腺癌转移的随机演化过程
Kimiyo N Yamamoto,Lin L Liu,Akira Nakamura et al.
Kimiyo N Yamamoto et al.
Despite recent progress in diagnostic and multimodal treatment approaches, most cancer deaths are still caused by metastatic spread and the subsequent growth of tumor cells in sites distant from the primary organ. So far, few quantitative s...
Development of Technologic Solutions to Address Complex Local Requirements of an International Prostate Cancer Clinical Quality Registry [0.03%]
国际前列腺癌临床质量登记处开发技术解决方案以应对复杂的本地需求
Fanny Sampurno,Ashwini Kannan,Mark Lucas et al.
Fanny Sampurno et al.
Purpose: To detail the process for importing a defined data set into a centralized global registry via a secure file transfer platform and to understand the barriers to the establishment of a centralized global registry. ...