Adam Struck,Brian Walsh,Alexander Buchanan et al.
Adam Struck et al.
Purpose: The analysis of cancer biology data involves extremely heterogeneous data sets, including information from RNA sequencing, genome-wide copy number, DNA methylation data reporting on epigenetic regulation, somatic...
Bayesian Framework for Detecting Gene Expression Outliers in Individual Samples [0.03%]
用于检测单个样本中的基因表达异常值的贝叶斯框架
John Vivian,Jordan M Eizenga,Holly C Beale et al.
John Vivian et al.
Purpose: Many antineoplastics are designed to target upregulated genes, but quantifying upregulation in a single patient sample requires an appropriate set of samples for comparison. In cancer, the most natural comparison...
Predicting Acute Graft-Versus-Host Disease Using Machine Learning and Longitudinal Vital Sign Data From Electronic Health Records [0.03%]
基于电子健康记录的生命体征纵向数据的机器学习预测急性移植物抗宿主病
Shengpu Tang,Grant T Chappell,Amanda Mazzoli et al.
Shengpu Tang et al.
Purpose: Acute graft-versus-host disease (aGVHD) remains a significant complication of allogeneic hematopoietic cell transplantation (HCT) and limits its broader application. The ability to predict grade II to IV aGVHD co...
CART-WHEEL.org: An Ethically Approved Online Database for Patient-Entered Data to Facilitate Rare Cancer Research [0.03%]
卡特轮-org：一个伦理批准的在线患者数据数据库，可促进罕见癌症研究
Damien Kee,Clare Parker,Susie Bae et al.
Damien Kee et al.
Purpose: Rare cancers are challenging for researchers, as clinicians and scientists have difficulty recruiting sufficient patient cases to power studies appropriately. Likewise, patients often are frustrated by a lack of ...
Frailty in Older Adults With Multiple Myeloma: A Study of US Veterans [0.03%]
美国退役军人多发性骨髓瘤患者衰老相关脆弱性的研究
Bindiya G Patel,Suhong Luo,Tanya M Wildes et al.
Bindiya G Patel et al.
Purpose: Age-associated cumulative decline across physiologic systems results in a diminished resistance to stressors, including cancer and its treatment, creating a vulnerable state known as frailty. Frailty is associate...
Cancer Informatics for Cancer Centers (CI4CC): Building a Community Focused on Sharing Ideas and Best Practices to Improve Cancer Care and Patient Outcomes [0.03%]
癌症中心的癌症信息学(CI4CC)：建立一个以分享观念和最佳实践、改善肿瘤护理和患者预后为目标的社区
Jill S Barnholtz-Sloan,Dana E Rollison,Amrita Basu et al.
Jill S Barnholtz-Sloan et al.
Cancer Informatics for Cancer Centers (CI4CC) is a grassroots, nonprofit 501c3 organization intended to provide a focused national forum for engagement of senior cancer informatics leaders, primarily aimed at academic cancer centers anywher...
Epigenetic Conservation Is a Beacon of Function: An Analysis Using Methcon5 Software for Studying Gene Methylation [0.03%]
表观遗传保守是功能的灯塔——利用MethCon 5软件研究基因甲基化的一个分析报告
Emil Hvitfeldt,Chao Xia,Kimberly D Siegmund et al.
Emil Hvitfeldt et al.
Purpose: Different epigenetic configurations allow one genome to develop into multiple cell types. Although the rules governing what epigenetic features confer gene expression are increasingly being understood, much remai...
The International Association for the Study of Lung Cancer Early Lung Imaging Confederation [0.03%]
国际肺部癌症研究协会早期肺部成像联合会
James L Mulshine,Ricardo S Avila,Ed Conley et al.
James L Mulshine et al.
Purpose: To improve outcomes for lung cancer through low-dose computed tomography (LDCT) early lung cancer detection. The International Association for the Study of Lung Cancer is developing the Early Lung Imaging Confede...
Standardizing Chemotherapy Regimen Nomenclature: A Proposal and Evaluation of the HemOnc and National Cancer Institute Thesaurus Regimen Content [0.03%]
化疗方案名称的标准化：关于HemOnc和美国国家癌症研究所词典内容的建议和评估
Samuel M Rubinstein,Peter C Yang,Andrew J Cowan et al.
Samuel M Rubinstein et al.
Purpose: Due to decades of nonstandardized approaches to the naming of chemotherapy regimens, representation in electronic health records and secondary systems is highly variable. This hampers efforts to understand patter...
Evidence-Based Network Approach to Recommending Targeted Cancer Therapies [0.03%]
基于证据的网络药理学方法推荐癌症靶向治疗药物
Jayaram Kancherla,Shruti Rao,Krithika Bhuvaneshwar et al.
Jayaram Kancherla et al.
Purpose: In this work, we introduce CDGnet (Cancer-Drug-Gene Network), an evidence-based network approach for recommending targeted cancer therapies. CDGnet represents a user-friendly informatics tool that expands the ran...