ORBIT-RT: A Real-Time, Open Platform for Knowledge-Based Quality Control of Radiotherapy Treatment Planning [0.03%]
基于知识的放射治疗计划质量控制的实时开放平台ORBIT-RT
Brent M Covele,Kartikeya S Puri,Karoline Kallis et al.
Brent M Covele et al.
Purpose: Access to knowledge-based treatment plan quality control has been hindered by the complexity of developing models and integration with different treatment planning systems (TPS). Online Real-time Benchmarking Inf...
Microsimulation Model for Evaluating the Cost-Effectiveness of Surveillance in BAP1 Pathogenic Variant Carriers [0.03%]
评估BAP1致病性变异携带者监测成本效益的微观模拟模型
Sebastian Walpole,Nicholas K Hayward,Antonia L Pritchard et al.
Sebastian Walpole et al.
Purpose: Pathogenic BAP1 germline variants cause a tumor-predisposition syndrome (BAP1-TPDS) linked to uveal melanoma, mesothelioma, cutaneous melanoma, and renal cell carcinoma. Surveillance of carriers of pathogenic BAP...
Feasibility of Fitness Tracker Usage to Assess Activity Level and Toxicities in Patients With Colorectal Cancer [0.03%]
用于评估结直肠癌患者活动量和毒副反应的运动追踪器使用可行性研究
William H Ward,Caitlin R Meeker,Elizabeth Handorf et al.
William H Ward et al.
Purpose: Performance status (PS) is a subjective assessment of patients' overall health. Quantification of physical activity using a wearable tracker (Fitbit Charge [FC]) may provide an objective measure of patient's over...
Health-Related Quality of Life Data in Cancer Clinical Trials for Drug Registration: The Value Beyond Reimbursement [0.03%]
肿瘤药物注册临床试验中的生命质量研究：超出报销价值的角度
Erinne Wasalski,Shashi Mehta
Erinne Wasalski
Purpose: A review of the literature was performed to evaluate how quality of life measures are collected, analyzed, and reported in cancer clinical trials intended to support drug registration.Health-related quality of li...
Development and Validation of a Prediction Model of Overall Survival in High-Risk Neuroblastoma Using Mechanistic Modeling of Metastasis [0.03%]
基于转移机制的高危神经母细胞瘤总生存预测模型的开发与验证
Sébastien Benzekry,Coline Sentis,Carole Coze et al.
Sébastien Benzekry et al.
Prognosis of high-risk neuroblastoma (HRNB) remains poor despite multimodal therapies. Better prediction of survival could help to refine patient stratification and better tailor treatments. We established a mechanistic model of metastasis ...
College of American Pathologists Cancer Protocols: From Optimizing Cancer Patient Care to Facilitating Interoperable Reporting and Downstream Data Use [0.03%]
美国病理学家协会癌症诊疗方案：从优化癌症患者护理到促进互操作性报告和后续数据使用
Vanda F Torous,Ross W Simpson,Jyoti P Balani et al.
Vanda F Torous et al.
The College of American Pathologists Cancer Protocols have offered guidance to pathologists for standard cancer pathology reporting for more than 35 years. The adoption of computer readable versions of these protocols by electronic health r...
Overall Survival With Second-Line Pembrolizumab in Patients With Non-Small-Cell Lung Cancer: Randomized Phase III Clinical Trial Versus Propensity-Adjusted Real-World Data [0.03%]
帕博利珠单抗二线治疗非小细胞肺癌患者的整体生存率：随机III期临床试验与倾向性调整的真实世界数据比较
Thomas Jemielita,Xiaoyun Nicole Li,Bilal Piperdi et al.
Thomas Jemielita et al.
Purpose: To compare and characterize overall survival (OS) differences between clinical trial data from the KEYNOTE-010 trial and real-world data (RWD) from the Flatiron Health database in patients with programmed death l...
Clinical Trial
JCO clinical cancer informatics. 2021 Jan:5:56-65. DOI:10.1200/CCI.20.00099 2021
BOIN Suite: A Software Platform to Design and Implement Novel Early-Phase Clinical Trials [0.03%]
BOIN套件：设计和实施新型早期临床试验的软件平台
Yanhong Zhou,Ruitao Lin,Ying-Wei Kuo et al.
Yanhong Zhou et al.
Purpose: Using novel Bayesian adaptive designs has great potential to improve the efficiency of early-phase clinical trials. A major barrier for clinical researchers to adopt novel designs is the lack of easy-to-use softw...
Machine Learning Frameworks to Predict Neoadjuvant Chemotherapy Response in Breast Cancer Using Clinical and Pathological Features [0.03%]
基于临床和病理特征使用机器学习框架预测乳腺癌新辅助化疗反应
Nicholas Meti,Khadijeh Saednia,Andrew Lagree et al.
Nicholas Meti et al.
Purpose: Neoadjuvant chemotherapy (NAC) is used to treat locally advanced breast cancer (LABC) and high-risk early breast cancer (BC). Pathological complete response (pCR) has prognostic value depending on BC subtype. Rat...
Artificial Intelligence Clinical Evidence Engine for Automatic Identification, Prioritization, and Extraction of Relevant Clinical Oncology Research [0.03%]
临床肿瘤研究的自动识别、优先排序和提取的相关人工智能临床证据引擎
Fernando Suarez Saiz,Corey Sanders,Rick Stevens et al.
Fernando Suarez Saiz et al.
Purpose: We developed a system to automate analysis of the clinical oncology scientific literature from bibliographic databases and match articles to specific patient cohorts to answer specific questions regarding the eff...