Melissa J Wolz,Katelyn E Sadler,Caela C Long et al.
Melissa J Wolz et al.
Changes in cold temperature sensitivity are often associated with chronic pain conditions. Progress in understanding the neurobiological mechanism underlying these changes and resulting development of effective therapies has been slowed by ...
Case Reports
Pain reports. 2016 Aug;1(2):e569. DOI:10.1097/PR9.0000000000000569 2016
Multivariate classification of pain-evoked brain activity in temporomandibular disorder [0.03%]
颞下颌疾病引起的脑电活动的多元分类疼痛
Daniel E Harper,Yash Shah,Eric Ichesco et al.
Daniel E Harper et al.
Introduction: Central nervous system factors are now understood to be important in the etiology of temporomandibular disorders (TMD), but knowledge concerning objective markers of central pathophysiology in TMD is lacking. Multivariate anal...
Effects of local and spinal administrations of mu-opioids on postoperative pain in aged versus adult mice [0.03%]
局部和脊髓内注射μ-阿片类药物对老龄与成年小鼠术后痛觉的影响
Jennifer Mecklenburg,Mayur J Patil,Wouter Koek et al.
Jennifer Mecklenburg et al.
Introduction: Suboptimal management of postoperative pain leads to increased risk of chronic opioid therapy, especially in elderly patients. Objectives: ...
Identifying brain nociceptive information transmission in patients with chronic somatic pain [0.03%]
慢性躯体疼痛患者脑痛觉信息传导的研究
Don A Davis,Mariam E Ghantous,Melissa A Farmer et al.
Don A Davis et al.
Introduction: Recent advances regarding mechanisms of chronic pain emphasize the role of corticolimbic circuitry in predicting risk for chronic pain, independently from site of injury-related parameters. These results com...
Identification of an epidermal keratinocyte AMPA glutamate receptor involved in dermatopathies associated with sensory abnormalities [0.03%]
与感觉异常相关性皮肤病的表皮角质细胞AMPA谷氨酸受体鉴定研究
David Cabañero,Takeshi Irie,Marta Celorrio et al.
David Cabañero et al.
Introduction: Epidermal keratinocytes are increasingly recognized as active participants in the sensory transduction of itch and pain, processes known to involve primary afferent glutamatergic neurons. However the role of...
Aubin Moutal,Nathan Eyde,Edwin Telemi et al.
Aubin Moutal et al.
Migraine is one of the world's most common neurological disorders. Current acute migraine treatments have sub-optimal efficacy and new therapeutic options are needed. Approaches targeting calcitonin gene related peptide (CGRP) signaling are...
Stephan Geuter,Jonathan T Cunningham,Tor D Wager
Stephan Geuter
Introduction: Although the motivation to avoid injury and pain is central to human and animal behavior, this goal compete priority with other homeostatic goals. Animal studies have shown that competing motivational states, such as thirst, r...
The potent, indirect adenosine monophosphate- activated protein kinase activator R419 attenuates mitogen-activated protein kinase signaling, inhibits nociceptor excitability, and reduces pain hypersensitivity in mice [0.03%]
有效的非直接腺苷酸活化蛋白激酶激活剂R419可减弱丝裂原活化蛋白激酶信号传导，抑制伤害感受器兴奋性并降低小鼠疼痛过敏度
Galo L Mejia,Marina N Asiedu,Yasumichi Hitoshi et al.
Galo L Mejia et al.
There is a great need for new therapeutics for the treatment of pain. A possible avenue to development of such therapeutics is to interfere with signaling pathways engaged in peripheral nociceptors that cause these neurons to become hyperex...
Effect of osteopathic manipulative treatment on pain in palliative care patients: a randomized placebo-controlled clinical trial [0.03%]
整骨保健操对姑息治疗患者疼痛的影响：随机安慰剂对照临床试验
Introduction: Standard osteopathic manipulative therapy (OMT) is used as a supportive care for pain management in cancer patients. Objectives: ...