Surabhi Kumar,Kevin C O&#x;Connor
Surabhi Kumar
Fc-swapped variant monoclonal antibodies reveal new mechanisms underlying Mycobacterium tuberculosis restriction.
Radiotherapy enhances anticancer CD8 T cell responses by cGAMP transfer through LRRC8A/C volume-regulated anion channels [0.03%]
放射治疗通过LRRC8A/C容积调节阴离子通道转移cGAMP增强抗肿瘤CD8T细胞反应
Limin Cao,Li Wang,Zhihong Li et al.
Limin Cao et al.
The volume-regulated anion channels (VRACs) transport osmolytes, neurotransmitters, and cyclic GMP-AMP (cGAMP) across the cell membrane to regulate cell volume and host defense. We report that the leucine-rich repeat-containing 8A/C (LRRC8A...
Riplet promotes lipid metabolism changes associated with CD8 T cell exhaustion and anti-PD-1 resistance in hepatocellular carcinoma [0.03%]
Riplet促进与肝细胞癌中CD8T细胞衰竭和抗PD-1耐药相关的脂质代谢改变
Junnan Liang,Jingyu Liao,Ruizhi Chang et al.
Junnan Liang et al.
The overall response rate to immunotherapy is modest in hepatocellular carcinoma (HCC), and immunotherapy resistance mechanisms are incompletely understood. We report that the E3 ubiquitin ligase Riplet is universally silenced by promoter h...
A Dock8-dependent mechanosensitive central actin pool maintains T cell shape and protects nucleus during migration [0.03%]
一种依赖于DOCK8的机械敏感型中央肌动蛋白池可维持T细胞形态并在迁移过程中保护细胞核
Connie Shen,Aysha Cerf,Jérémy Postat et al.
Connie Shen et al.
Immune cells navigate through complex tissue architectures by extensive cellular deformation, low adhesion, and high cell velocities. Loss-of-function mutations in Dedicator of Cytokinesis 8 (Dock8) are associated with immunodeficiency as i...
A linear ontogeny accounts for the development of naive, memory, and tumor-infiltrating regulatory T cells in mice [0.03%]
小鼠 naive、记忆和肿瘤浸润调节性T细胞的发育具有线性发生学特征
Sanmoy Pathak,Thea Hogan,Sanket Rane et al.
Sanmoy Pathak et al.
Regulatory T cells (Treg cells) are critical regulators of adaptive immunity and the pathophysiology of antitumoral immunity. Treg cells are both generated during thymic development and induced from peripheral conventional T cells. How thes...
TNF switches homeostatic efferocytosis to lytic caspase-8-dependent pyroptosis and IL-1β maturation [0.03%]
肿瘤坏死因子切换稳态致吞噬作用到裂解性caspase-8依赖的细胞焦亡和IL-1β成熟
Hayley I Muendlein,Wilson M Connolly,Jamie Leiriao et al.
Hayley I Muendlein et al.
Efferocytosis, wherein phagocytes engulf dead or dying cells, is a critical function of macrophages that supports cellular turnover, tissue repair, and resolution of inflammation. Despite its well-established anti-inflammatory mechanism in ...
CLNS1A regulates genome stability and cell cycle progression to control CD4 T cell function and autoimmunity [0.03%]
CLNS1A通过调节基因组稳定性和细胞周期进程来控制CD4T细胞的功能和自身免疫反应
Liwei Wang,Lucile Noyer,Miki Jishage et al.
Liwei Wang et al.
Pathogenic CD4 T cells drive autoimmunity in diseases such as multiple sclerosis (MS) and inflammatory bowel disease (IBD). Through a forward genetic screen, we identified chloride nucleotide-sensitive channel 1A (CLNS1A) as a key regulator...
PSGL-1 is a phagocytosis checkpoint that enables tumor escape from macrophage clearance [0.03%]
PSGL-1是促进肿瘤逃逸巨噬细胞清除的吞噬检查点蛋白质
Cheng Zhong,Lixiang Wang,Yujia Liu et al.
Cheng Zhong et al.
Cancer immunotherapies exhibit impressive efficacy in some cancers but show only limited benefits for refractory hematological malignancies. The complex immune escape mechanisms of hematological cancers remain unclear. Here, we found that P...
Shivangi Dave,André Ballesteros-Tato
Shivangi Dave
T follicular helper cells (TFH cells) are essential for germinal center (GC) formation and maintenance. However, recent insights reveal that TFH cells play additional immune regulatory roles beyond their traditional B cell helper function. ...
An Il12 mRNA-LNP adjuvant enhances mRNA vaccine-induced CD8 T cell responses [0.03%]
IL-12 mRNA-LNP佐剂增强mRNA疫苗诱导的CD8+t细胞反应
Emily A Aunins,Anthony T Phan,Mohamad-Gabriel Alameh et al.
Emily A Aunins et al.
Optimizing vaccine design to induce CD8 T cell responses has been challenging, but lipid nanoparticle (LNP)-encapsulated mRNA vaccines effectively generate CD8 T cell memory. Interleukin-12 (IL-12) supports CD8 T cell expansion and acquisit...