Single-cell multiomics identifies Tcf1 and Lef1 as key initiators of early thymic progenitor fate [0.03%]
单细胞多组学鉴定出Tcf1和Lef1是早期胸腺祖细胞命运的关键启动因子
Xin Zhao,Shengen Shawn Hu,Wen-Han Lee et al.
Xin Zhao et al.
Bone marrow-derived multipotent hematopoietic progenitors seed the thymus and generate early thymic progenitors (ETPs). However, the factors governing ETP formation remain poorly defined. Using single-cell RNA sequencing (scRNA-seq) and sin...
It's getting hot in here: Heating up the tumor microenvironment with an oral HO-1 inhibitor [0.03%]
这里越来越热了——通过口服HO-1抑制剂加热肿瘤微环境
Cait A McAlindon,Rachael A Clark
Cait A McAlindon
A new orally bioavailable HO-1 inhibitor enhances tumor clearance after chemotherapy in mice by enhancing the recruitment of CD8 T cells.
METTL1-mediated m7G methylation of Sarm1 mRNA promotes macrophage inflammatory responses and multiple organ injury [0.03%]
METTL1介导的Sarm1 mRNA甲基化促进巨噬细胞炎症反应和多器官损伤
Chao Hou,Xin-Ru Zhang,Jie Wei et al.
Chao Hou et al.
RNA modifications regulate phenotype and function of macrophages by regulating RNA translation, splicing, and stability. However, the role of N7-methylguanosine (m7G) modification in macrophages and inflammation remains unexplored. In this ...
Enkephalin-producing regulatory T cells in the skin restrain local inflammation through control of nociception [0.03%]
皮肤中的阿片肽产生调节性T细胞通过控制伤害感受来抑制局部炎症反应
Alejandra Mendoza,Regina Bou-Puerto,Juan Sebastian Jara et al.
Alejandra Mendoza et al.
The skin integrates diverse signals discerned by sensory neurons and immune cells to elicit adaptive responses to a range of stresses. Considering interactions between nervous and immune systems, we examined whether regulatory T (Treg) cell...
DDX55 safeguards naïve T cell homeostasis by suppressing activation-promoting transposable elements [0.03%]
DDX55通过抑制促进激活的转座元件来保障初始T细胞稳态
Mengyue Wu,Kepan Linghu,Qimin Yin et al.
Mengyue Wu et al.
Naïve T cells are maintained in a homeostatic state to preserve a stable T cell pool with diverse T cell receptor (TCR) repertoires, ensuring preparedness for priming. However, the underlying mechanisms controlling naïve T cell homeostasi...
Loss-of-function mutations ensure that response to immune checkpoint therapy is NOD2 be denied [0.03%]
NOD2功能丧失型突变确保免疫检查点治疗无效
Ana C Anderson,Manu Rangachari
Ana C Anderson
Loss-of-function mutations in NOD2 may predict positive response to PD-1 blockade monotherapy in cancer.
MAIT and other innate-like T cells integrate adaptive immune responses to modulate interval-dependent reactogenicity to mRNA vaccines [0.03%]
MAIT细胞和其他先天性T细胞通过调节mRNA疫苗的免疫原性来整合适应性免疫反应
Ali Amini,Lucy C Garner,Robert H Shaw et al.
Ali Amini et al.
Adenoviral (Ad) vectors and mRNA vaccines exhibit distinct patterns of immune responses and reactogenicity, but underpinning mechanisms remain unclear. We longitudinally compared homologous ChAdOx1 nCoV-19 and BNT162b2 vaccination, focusing...
Dosing interval is a major factor determining the quality of T cells induced by SARS-CoV-2 mRNA and adenoviral vector vaccines [0.03%]
剂量间隔是决定SARS-CoV-2 mRNA和腺病毒载体疫苗诱导T细胞质量的关键因素
Sam M Murray,Ali Amini,Helen Ferry et al.
Sam M Murray et al.
Functional T cell responses are crucial for protective immunity induced by COVID-19 vaccination, but factors influencing the quality of these responses are incompletely understood. We used an activation-induced marker (AIM) assay and single...
HIV broadly neutralizing antibody precursors to the Apex epitope induced in nonhuman primates [0.03%]
非人灵长类动物中广谱中和抗体Apex表位的前体被诱导出来
Krystal M Ma,Henry J Sutton,Payal P Pratap et al.
Krystal M Ma et al.
An effective prophylactic HIV vaccine will likely need to induce broadly neutralizing antibodies (bnAbs). bnAbs to the Apex region of the HIV envelope glycoprotein (Env) are promising targets for vaccination because of their relatively low ...
Reprogramming intratumoral Treg cells by morpholino-mediated splicing of FOXP3 for cancer immunotherapy [0.03%]
用于癌症免疫治疗的基于反义寡核苷酸介导重编程肿瘤浸润Tregs细胞的方法和组合物
Yujing Li,Naresh Singh,Chuanpeng Dong et al.
Yujing Li et al.
Regulatory T cells (Treg cells) represent a primary barrier to the development of effective antitumor immunity. Here, we report that reprogramming Treg cells by shifting the expression of FOXP3 from its full-length isoform (FOXP3FL) to a sh...