Meningeal γδ T cell-derived IL-17 controls synaptic plasticity and short-term memory [0.03%]
脑膜γδT细胞源性的IL-17调控突触可塑性和短期记忆
Miguel Ribeiro,Helena C Brigas,Mariana Temido-Ferreira et al.
Miguel Ribeiro et al.
The notion of "immune privilege" of the brain has been revised to accommodate its infiltration, at steady state, by immune cells that participate in normal neurophysiology. However, the immune mechanisms that regulate learning and memory re...
Interleukin-36γ-producing macrophages drive IL-17-mediated fibrosis [0.03%]
产生IL-36γ的巨噬细胞介导纤维化中的IL-17路径
Sven D Sommerfeld,Christopher Cherry,Remi M Schwab et al.
Sven D Sommerfeld et al.
Biomaterials induce an immune response and mobilization of macrophages, yet identification and phenotypic characterization of functional macrophage subsets in vivo remain limited. We performed single-cell RNA sequencing analysis on macropha...
Kyle Burrows,Arthur Mortha
Kyle Burrows
Circadian clock proteins BMAL1 and REV-ERBα harmonize the development and function of ILC3 (see related articles by Teng et al. and Wang et al.). Copyri...
Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells [0.03%]
分子钟对3型先天淋巴细胞昼夜节律依赖性和非昼夜节律依赖性的影响
Qianli Wang,Michelle L Robinette,Cyrielle Billon et al.
Qianli Wang et al.
Many gut functions are attuned to circadian rhythm. Intestinal group 3 innate lymphoid cells (ILC3s) include NKp46+ and NKp46- subsets, which are RORγt dependent and provide mucosal defense through secretion of interleukin-22 (IL-22) and I...
A circadian clock is essential for homeostasis of group 3 innate lymphoid cells in the gut [0.03%]
肠道固有淋巴样细胞群的稳态需要昼夜钟的功能
Fei Teng,Jeremy Goc,Lei Zhou et al.
Fei Teng et al.
Group 3 innate lymphoid cells (ILC3s) critically orchestrate host-microbe interactions in the healthy mammalian intestine and become substantially impaired in the context of inflammatory bowel disease (IBD). However, the molecular pathways ...
Lin28b controls a neonatal to adult switch in B cell positive selection [0.03%]
Lin28b控制B细胞阳性选择从新生儿到成人阶段的转换
Stijn Vanhee,Hugo Åkerstrand,Trine Ahn Kristiansen et al.
Stijn Vanhee et al.
The ability of B-1 cells to become positively selected into the mature B cell pool, despite being weakly self-reactive, has puzzled the field since its initial discovery. Here, we explore changes in B cell positive selection as a function o...
Myeloid cell-synthesized coagulation factor X dampens antitumor immunity [0.03%]
髓系细胞合成的凝血因子X抑制抗肿瘤免疫反应
Claudine Graf,Petra Wilgenbus,Sven Pagel et al.
Claudine Graf et al.
Immune evasion in the tumor microenvironment (TME) is a crucial barrier for effective cancer therapy, and plasticity of innate immune cells may contribute to failures of targeted immunotherapies. Here, we show that rivaroxaban, a direct inh...
Nucleoside-modified mRNA encoding HSV-2 glycoproteins C, D, and E prevents clinical and subclinical genital herpes [0.03%]
经修饰的编码单纯疱疹病毒 2 型糖蛋白 C、D 和 E 的核苷酸 mRNA 可预防临床型和亚临床型生殖器疱疹
Sita Awasthi,Lauren M Hook,Norbert Pardi et al.
Sita Awasthi et al.
The goals of a genital herpes vaccine are to prevent painful genital lesions and reduce or eliminate subclinical infection that risks transmission to partners and newborns. We evaluated a trivalent glycoprotein vaccine containing herpes sim...
Germinal center TFH cells: T(w)o be or not t(w)o be, IL-6 is the answer [0.03%]
生发中心TFH细胞：T(W)O BE OR NOT T(W)O BE，IL-6 是答案
Pengcheng Zhou,Kaili Liang,Di Yu
Pengcheng Zhou
IL-6 inhibits the expression of IL-2Rβ (CD122) in germinal center TFH cells to maintain IL-2 hyporesponsiveness (see the related Research Article by Papillion et al.). ...
Inhibition of IL-2 responsiveness by IL-6 is required for the generation of GC-TFH cells [0.03%]
IL-6通过抑制IL-2反应性促进生发中心TFH细胞的生成
Amber Papillion,Michael D Powell,Danielle A Chisolm et al.
Amber Papillion et al.
Sustained T cell receptor (TCR) stimulation is required for maintaining germinal center T follicular helper (GC-TFH) cells. Paradoxically, TCR activation induces interleukin-2 receptor (IL-2R) expression and IL-2 production, thereby initiat...