Protocol to evaluate the efficacy and safety of tolvaptan in patients with refractory ascites after liver resection: an open-label, single-arm phase I/II study [0.03%]
评估托伐普坦对肝切除术后难治性腹水患者的有效性和安全性的一种临床研究方案：一项开放标签，单臂，I / II 期研究
Yosuke Namba,Tsuyoshi Kobayashi,Shintaro Kuroda et al.
Yosuke Namba et al.
Background: In patients with chronic liver diseases such as cirrhosis, massive ascites after hepatic resection is the cause of prolonged hospitalization and worsening prognosis. Recently, the efficacy of tolvaptan in refr...
Paul H Sugarbaker,Tom Deng
Paul H Sugarbaker
Background: Peritoneal metastases from gastrointestinal or gynecologic malignancy are a prominent part of the natural history of these diseases. Peritoneal metastases, if not effectively treated, will result in a decrease...
The MARECA (national study of management of breast cancer locoregional recurrence and oncological outcomes) study: protocol for a prospective, multicentre cohort study [0.03%]
MARECA（乳腺癌局部复发及其肿瘤学结局管理的国家研究）研究：一项前瞻性多中心队列研究的方案
Sue M Hartup,Jenna L Morgan,Vinton Wt Cheng et al.
Sue M Hartup et al.
Background: Despite a UK 5-year breast cancer survival rate of 86.6%, patients may develop breast cancer recurrence within the same breast after breast conserving surgery, as well as in the remaining skin or chest wall af...
A new minimally invasive, nonexcisional, surgical browlift technique with minimal scarring: a protocol for a prospective observational study [0.03%]
一种新型的最小创伤无切除微创提眉术以形成极小疤痕：一项前瞻性观察研究的方案
Frank W de Jongh,Laurens B R Kooiman,Elijah E Sanches et al.
Frank W de Jongh et al.
Background: The aim of this study is to prospectively evaluate the new minimal invasive (MINE) browlift technique with possibly superior results and minimal visible scarring. ...
Artificial intelligence-enabled ophthalmoscopy for papilledema: a systematic review protocol [0.03%]
人工智能辅助的眼底镜检查视乳头水肿的系统评价方案
Lekaashree Rambabu,Brandon G Smith,Stasa Tumpa et al.
Lekaashree Rambabu et al.
Papilledema is a pathology delineated by the swelling of the optic disc secondary to raised intracranial pressure (ICP). Diagnosis by ophthalmoscopy can be useful in the timely stratification of further investigations, such as magnetic reso...
Rural trauma team development training amongst medical trainees and traffic law enforcement professionals in a low-income country: a protocol for a prospective multicenter interrupted time series [0.03%]
在低收入国家对医疗学员和交通执法专业人员进行农村创伤团队开发培训：前瞻性多中心间断时间序列的试验方案
Herman Lule,Michael Mugerwa,Robinson SSebuufu et al.
Herman Lule et al.
Background: Road traffic injuries and their resulting mortality disproportionately affect rural communities in low-middle-income countries (LMICs) due to limited human and infrastructural resources for postcrash care. Evi...
A systematic scoping review protocol to summarise and appraise the use of artificial intelligence in the analysis of digital videos of invasive general surgical procedures [0.03%]
一项系统性综述协议：总结和评估人工智能在分析侵入式普通外科手术数字视频中的应用
Anni King,George Fowler,Rhiannon C Macefield et al.
Anni King et al.
Background: Intraoperative video recordings are a valuable addition to operative written documentation. However, the review of these videos often requires surgical expertise and takes considerable time. While a large amou...
Randomized trial of intravenous versus bidirectional chemotherapy after cytoreductive surgery for malignant peritoneal mesothelioma [0.03%]
术后静脉化疗与双途径化疗治疗恶性腹膜间皮oma的随机临床试验
Paul H Sugarbaker
Paul H Sugarbaker
Background: Malignant peritoneal mesothelioma (MPM) is a rare disease that progresses within the peritoneal cavity and only disseminates to systemic sites in the terminal months of the disease. For this malignancy, there ...
Research protocol to identify progression and death amongst patients with metastatic hormone-sensitive prostate cancer treated with available treatments: PIONEER IMI's "big data for better outcomes" program [0.03%]
HOVON-76/PIONEER IMI“大数据改善预后”计划：确定可用疗法治疗的转移性激素敏感性前列腺癌患者进展和死亡的研究方案
Juan Gomez Rivas,Rossella Nicoletti,Laura Ibáñez et al.
Juan Gomez Rivas et al.
Androgen deprivation therapy-based with or without first-generation anti-androgens, was the standard of care for patients with metastatic hormone-sensitive prostate cancer (mHSPC) for decades. However, the development of docetaxel chemother...
Framework for a living systematic review and meta-analysis for the surgical treatment of bladder cancer: introducing EVIglance to urology [0.03%]
膀胱癌手术治疗的动态系统综述和meta分析框架——引入EVIGLANCE至泌尿外科领域
Victoria L S Wieland,Daniel Uysal,Pascal Probst et al.
Victoria L S Wieland et al.
Background: Knowledge of current and ongoing studies is critical for identifying research gaps and enabling evidence-based decisions for individualized treatment. However, the increasing number of scientific publications ...