A systematic evaluation of analogs and automated read-across prediction of estrogenicity: A case study using hindered phenols [0.03%]
有关雌激素类似物的系统评价及运用读取预测阻碍酚类雌激素性的案例研究
Prachi Pradeep,Kamel Mansouri,Grace Patlewicz et al.
Prachi Pradeep et al.
Read-across is an important data gap filling technique used within category and analog approaches for regulatory hazard identification and risk assessment. Although much technical guidance is available that describes how to develop category...
Performance of Machine Learning Algorithms for Qualitative and Quantitative Prediction Drug Blockade of hERG1 channel [0.03%]
机器学习算法定性和定量预测药物阻断hERG1通道性能的研究
Soren Wacker,Sergei Yu Noskov
Soren Wacker
Drug-induced abnormal heart rhythm known as Torsades de Pointes (TdP) is a potential lethal ventricular tachycardia found in many patients. Even newly released anti-arrhythmic drugs, like ivabradine with HCN channel as a primary target, blo...
Human blood gene signature as a marker for smoking exposure: computational approaches of the top ranked teams in the sbv IMPROVER Systems Toxicology challenge [0.03%]
基于人类血液基因表达谱的吸烟暴露标志物：sbv IMPROVER系统毒理学挑战赛中排名靠前团队的计算方法研究
Adi L Tarca,Xiaofeng Gong,Roberto Romero et al.
Adi L Tarca et al.
Crowdsourcing has emerged as a framework to address methodological challenges in omics data analysis and assess the extent to which omics data are predictive of phenotypes of interest. The sbv IMPROVER Systems Toxicology Challenge was desig...
Species translatable blood gene signature as a marker of exposure to smoking: computational approaches of the top ranked teams in the sbv IMPROVER Systems Toxicology challenge [0.03%]
物种可译的血液基因特征作为吸烟暴露标记：sbv improver系统毒理学挑战赛中排名靠前团队的计算方法
Ömer Sinan Saraç,Rahul Kumar,Sandeep Kumar Dhanda et al.
Ömer Sinan Saraç et al.
Crowdsourcing has been used to address computational challenges in systems biology and assess translation of findings across species. Sub-challenge 2 of the sbv IMPROVER Systems Toxicology Challenge was designed to determine whether a commo...
Ab initio chemical safety assessment: A workflow based on exposure considerations and non-animal methods [0.03%]
从头算化学安全评估：基于暴露考虑和非动物方法的工作流程
Elisabet Berggren,Andrew White,Gladys Ouedraogo et al.
Elisabet Berggren et al.
We describe and illustrate a workflow for chemical safety assessment that completely avoids animal testing. The workflow, which was developed within the SEURAT-1 initiative, is designed to be applicable to cosmetic ingredients as well as to...