Computational models for the assessment of manufactured nanomaterials: Development of model reporting standards and mapping of the model landscape [0.03%]
用于评估纳米材料的计算模型：制定模型报告标准和绘制模型概览地图
L Lamon,D Asturiol,A Vilchez et al.
L Lamon et al.
Different types of computational models have been developed for predicting the biokinetics, environmental fate, exposure levels and toxicological effects of chemicals and manufactured nanomaterials (MNs). However, these models are not descr...
Physiologically based mathematical models of nanomaterials for regulatory toxicology: A review [0.03%]
基于生理学的纳米材料监管毒理学数学模型综述
L Lamon,D Asturiol,A Vilchez et al.
L Lamon et al.
The development of physiologically based (PB) models to support safety assessments in the field of nanotechnology has grown steadily during the last decade. This review reports on the availability of PB models for toxicokinetic (TK) and tox...
Next generation physiologically based kinetic (NG-PBK) models in support of regulatory decision making [0.03%]
下一代基于生理的毒性动力学模型（NG-PBTK）在决策支持中的应用
A Paini,J A Leonard,E Joossens et al.
A Paini et al.
The fields of toxicology and chemical risk assessment seek to reduce, and eventually replace, the use of animals for the prediction of toxicity in humans. In this context, physiologically based kinetic (PBK) modelling based on in vitro and ...
Frequent Modulation of the Sterol Regulatory Element Binding Protein (SREBP) by Chemical Exposure in the Livers of Rats [0.03%]
化学物质暴露大鼠肝脏中sterol regulatory element binding protein(SREBP)的频繁调节作用
J Christopher Corton
J Christopher Corton
Inappropriate activation of sterol regulatory element-binding proteins (SREBPs) can lead to non-alcoholic fatty liver disease (NAFLD). To link chemical exposure to SREBP activity, a previously characterized gene expression biomarker (Rooney...
Homology models of mouse and rat estrogen receptor- α ligand-binding domain created by in silico mutagenesis of a human template: molecular docking with 17ß-estradiol, diethylstilbestrol, and paraben analogs [0.03%]
利用计算诱变的人类模板构建的小鼠和大鼠雌激素受体α配体结合区同源模型：与17β雌二醇、双酚A及对羟基苯甲酸酯类似物的分子对接研究
Thomas L Gonzalez,James M Rae,Justin A Colacino et al.
Thomas L Gonzalez et al.
Crystal structures exist for human, but not rodent, estrogen receptor-α ligand-binding domain (ERα-LBD). Consequently, rodent studies involving binding of compounds to ERα-LBD are limited in their molecular-level interpretation and extra...
Chemical-agnostic hazard prediction: statistical inference of in vitro toxicity pathways from proteomics responses to chemical mixtures [0.03%]
基于蛋白质组响应的化学混合物体内毒性通路的统计推理及危害预测的化学无关性研究
Jeffrey A Ross,Barbara Jane George,Maribel Bruno et al.
Jeffrey A Ross et al.
Toxicity pathways have been defined as normal cellular pathways that, when sufficiently perturbed as a consequence of chemical exposure, lead to an adverse outcome. If an exposure alters one or more normal biological pathways to an extent t...
Predictive Models for Acute Oral Systemic Toxicity: A Workshop to Bridge the Gap from Research to Regulation [0.03%]
急性口服全身毒性预测模型研讨会：从研究到监管的通桥工程
Nicole C Kleinstreuer,Agnes Karmaus,Kamel Mansouri et al.
Nicole C Kleinstreuer et al.
In early 2018, the Interagency Coordinating Committee for the Validation of Alternative Methods (ICCVAM) published the "Strategic Roadmap for Establishing New Approaches to Evaluate the Safety of Chemicals and Medical Products in the United...
A Workflow for Identifying Metabolically Active Chemicals to Complement in vitro Toxicity Screening [0.03%]
一种识别代谢活跃化学品的工作流程，以补充体外毒性筛查
Jeremy A Leonard,Caroline Stevens,Kamel Mansouri et al.
Jeremy A Leonard et al.
The new paradigm of toxicity testing approaches involves rapid screening of thousands of chemicals across hundreds of biological targets through use of in vitro assays. Such assays may lead to false negatives when the complex metabolic proc...
The sbv IMPROVER Systems Toxicology Computational Challenge: Identification of Human and Species-Independent Blood Response Markers as Predictors of Smoking Exposure and Cessation Status [0.03%]
sbv IMPROVER系统毒理学计算挑战：鉴定人类和跨物种血液生物标志物作为吸烟暴露与戒断状态的预测指标
Vincenzo Belcastro,Carine Poussin,Yang Xiang et al.
Vincenzo Belcastro et al.
Cigarette smoking entails chronic exposure to a mixture of harmful chemicals that trigger molecular changes over time, and is known to increase the risk of developing diseases. Risk assessment in the context of 21st century toxicology relie...
Navigating through the minefield of read-across tools: A review of in silico tools for grouping [0.03%]
审阅计算分组工具：穿行工具雷区的思考
Patlewicz Grace,Helman George,Pradeep Prachi et al.
Patlewicz Grace et al.
Read-across is a popular data gap filling technique used within analogue and category approaches for regulatory purposes. In recent years there have been many efforts focused on the challenges involved in read-across development, its scient...