Andrew P Worth
Andrew P Worth
This commentary explores the contribution of computational toxicology to chemical safety assessment in the context of the broad policy challenges faced by the European Union. The state of the European Environment is considered from the pers...
Novel application of normalized pointwise mutual information (NPMI) to mine biomedical literature for gene sets associated with disease: use case in breast carcinogenesis [0.03%]
一种新颖的规范化点互信息(NPMI)应用方法用于挖掘与疾病相关的基因集合的生物医学文献：乳腺癌变用例分析
Sean M Watford,Rachel G Grashow,Vanessa Y De La Rosa et al.
Sean M Watford et al.
Advances in technology within biomedical sciences have led to an inundation of data across many fields, raising new challenges in how best to integrate and analyze these resources. For example, rapid chemical screening programs like the US ...
Clemens Wittwehr,Paul Blomstedt,John Paul Gosling et al.
Clemens Wittwehr et al.
As the basis for managing the risks of chemical exposure, the Chemical Risk Assessment (CRA) process can impact a substantial part of the economy, the health of hundreds of millions of people, and the condition of the environment. However, ...
Extending the Generalised Read-Across approach (GenRA): A systematic analysis of the impact of physicochemical property information on read-across performance [0.03%]
扩展广义读取跨域方法（GenRA）：物理化学属性信息对读取跨域性能影响的系统分析
George Helman,Imran Shah,Grace Patlewicz
George Helman
Read-across is a useful data gap filling technique used within category and analogue approaches in regulatory hazard and risk assessment. Recently we developed an algorithmic, approach called Generalised Read-Across (GenRA) (Shah et al., 20...
Time-dependent behavioral data from zebrafish reveals novel signatures of chemical toxicity using point of departure analysis [0.03%]
时间依赖的行为数据揭示了斑马鱼化学毒性的新型标志物分析方法
Dennis G Thomas,Harish Shankaran,Lisa Truong et al.
Dennis G Thomas et al.
High-content imaging of larval zebrafish behavior can be used as a screening approach to rapidly evaluate the relative potential for chemicals to cause toxicity. However, most statistical methods applied to these data transform movement val...
Integration of curated and high-throughput screening data to elucidate environmental influences on disease pathways [0.03%]
整合人工精选和高通量筛选数据以阐明环境因素对疾病途径的影响
Marissa B Kosnik,Antonio Planchart,Skylar W Marvel et al.
Marissa B Kosnik et al.
Addressing the complex relationship between public health and environmental exposure requires multiple types and sources of data. An important source of chemical data derives from high-throughput screening (HTS) efforts, such as the Tox21/T...
Utilizing Threshold of Toxicological Concern (TTC) with High Throughput Exposure Predictions (HTE) as a Risk-Based Prioritization Approach for thousands of chemicals [0.03%]
利用高通量暴露预测（HTE）和毒理学关注阈值（TTC）进行风险优先级划分数千种化学品的方法
Grace Patlewicz,John F Wambaugh,Susan P Felter et al.
Grace Patlewicz et al.
Regulatory agencies across the world are facing the challenge of performing risk-based prioritization of thousands of chemicals in commerce. Here, we present an approach using the Threshold of Toxicological Concern (TTC) combined with heuri...
BCScreen: A gene panel to test for breast carcinogenesis in chemical safety screening [0.03%]
用于化学品安全筛查的乳腺癌发生基因检测板(BCScreen)
Rachel G Grashow,Vanessa Y De La Rosa,Sean M Watford et al.
Rachel G Grashow et al.
Targeted gene lists have been used in clinical settings to specify breast tumor type, and to predict breast cancer prognosis and response to treatment. Separately, panels have been curated to predict systemic toxicity and xenoestrogen activ...
Role of Physiologically Based Kinetic modelling in addressing environmental chemical mixtures - A review [0.03%]
基于生理的 kinetic模型在解决环境化学混合物问题中的作用-综述文章
Anteneh Desalegn,Stephanie Bopp,David Asturiol et al.
Anteneh Desalegn et al.
The role of Physiologically Based Kinetic (PBK) modelling in assessing mixture toxicology has been growing for the last three decades. It has been widely used to investigate and address interactions in mixtures. This review describes the cu...
Unlocking the potential of in silico chemical safety assessment - A report on a cross-sector symposium on current opportunities and future challenges [0.03%]
基于跨行业研讨会的报告：抓住计算化学安全性评估当前机遇及未来挑战的契机
Mark T D Cronin,Judith C Madden,Chihae Yang et al.
Mark T D Cronin et al.
In silico chemical safety assessment can support the evaluation of hazard and risk following potential exposure to a substance. A symposium identified a number of opportunities and challenges to implement in silico methods, such as quantita...