Mark K Borsody,Emilio Sacristan
Mark K Borsody
Stimulation of the autonomic parasympathetic fibers of the facial nerve system (hereafter simply "facial nerve") rapidly dilates the cerebral arteries and increases cerebral blood flow whether that stimulation is delivered at the facial ner...
Targeting oxidative stress for the treatment of ischemic stroke: Upstream and downstream therapeutic strategies [0.03%]
氧化应激在缺血性脑卒中治疗中的作用及对策：上游和下游疗法
Wenjun Li,Shaohua Yang
Wenjun Li
Excessive oxygen and its chemical derivatives, namely reactive oxygen species (ROS), produce oxidative stress that has been known to lead to cell injury in ischemic stroke. ROS can damage macromolecules such as proteins and lipids and leads...
Science, ethics and communication remain essential for the success of cell-based therapies [0.03%]
科学、伦理及沟通仍是细胞疗法成功的关键因素
Massimo Dominici,Karen M Nichols,Aaron D Levine et al.
Massimo Dominici et al.
Cell-based therapeutics, such as marrow or peripheral blood stem cell transplantation, are a standard of care for certain malignancies. More recently, a wider variety of cell-based therapeutics including the use of mesenchymal stromal/stem ...
Nonhuman primate model in clinical modeling of diseases for stem cell therapy [0.03%]
用于干细胞治疗的疾病临床研究的非人灵长类模型
Gourav R Choudhury,Jeffrey Kim,Patrice A Frost et al.
Gourav R Choudhury et al.
Nonhuman primates (NHPs) are alike humans in size, behavior, physiology, biochemistry, and immunology. Given close similarities to humans, the NHP model offers exceptional opportunities to understand the biological mechanisms and translatio...
A therapeutic shock propels Schwann cells to proliferate in peripheral nerve injury [0.03%]
治疗性刺激可促进施万细胞在周围神经损伤中的增殖
Christina Map Schuh,Thomas Hausner,Heinz R Redl
Christina Map Schuh
Damage to the peripheral nervous system (PNS) is a prevalent issue and represents a great burden to patients. Although the PNS has a good capacity for regeneration, regeneration over long distances poses several difficulties. Several recent...
Creatine supplementation improves neural progenitor cell survival in Huntington's disease [0.03%]
肌酸补充改善亨廷顿舞蹈病小鼠神经前体细胞的存活率
Robert H Andres,Theo Wallimann,Hans R Widmer
Robert H Andres
Preclinical and clinical studies suggest that striatal transplantation of neural stem cells (NSCs) and neural progenitor cells (NPCs) may be an appealing and valuable system for treating Huntington's disease. Nevertheless, for a neural repl...
Finding effective biomarkers for pediatric traumatic brain injury [0.03%]
寻找有效的生物标志物以评估儿童创伤性脑损伤病情严重程度及预后
Olena Y Glushakova,Alexander V Glushakov,Ronald L Hayes
Olena Y Glushakova
As traumatic brain injury (TBI) continues to affect children and young adults worldwide, research on reliable biomarkers grows as a possible aid in determining the severity of injury. However, many studies have revealed that diverse biomark...
Susanna Rosi
Susanna Rosi
Traumatic brain injury (TBI) activates the simultaneous proliferation of various pro- and anti-inflammatory molecules. Considering the amount of factors participating, this response is naturally complex. However, there is an increasing tren...
Clinical application of oligodendrocyte precursor cells for cell-based therapy [0.03%]
少突胶质细胞前体细胞的临床应用及其作为治疗手段的效果评估研究
Naohiro Egawa,Hajime Takase,Lok Josephine et al.
Naohiro Egawa et al.
Oligodendrocyte precursor cells (OPCs), which give rise to mature oligodendrocytes (OLs), play important roles in maintaining white matter function. Even during the adulthood period, OPCs comprise roughly 5% of all cells in the forebrain an...
Yun Wang,Brandon K Harvey
Yun Wang
The neurotransmitter glutamate is released following ischemic brain damage, and its excitotoxic effects contribute greatly to the development of stroke. Because this release of glutamate occurs within minutes, therapeutic drugs targeting th...