Markku Kaste
Markku Kaste
Neurotrophic factor-based strategies to enhance survival and differentiation of neural progenitor cells toward the dopaminergic phenotype [0.03%]
基于神经营养素的策略促进多巴胺能神经元前体细胞存活和分化的研究进展
Stefano Di Santo,Hans R Widmer
Stefano Di Santo
Parkinson's disease (PD) is a neurodegenerative disorder that presents with hallmark clinical symptoms of tremor at rest, bradykinesia, and muscle rigidity. Stem cell therapy has emerged as an experimental treatment for PD. However, optimiz...
Effects of labeling human mesenchymal stem cells with superparamagnetic iron oxides on cellular functions and magnetic resonance contrast in hypoxic environments and long-term monitoring [0.03%]
超顺磁性氧化铁标记人骨髓间充质干细胞对细胞功能及缺氧环境MR信号的影响及其长期示踪能力研究
Jens T Rosenberg,Xuegang Yuan,Shannon N Helsper et al.
Jens T Rosenberg et al.
Ischemia, which involves decreased blood flow to a region and a corresponding deprivation of oxygen and nutrients, can be induced as a consequence of stroke or heart attack. A prevalent disease that affects many individuals worldwide, ische...
Encapsulated stem cells ameliorate depressive-like behavior via growth factor secretion [0.03%]
细胞分泌生长因子减轻抑郁样行为
Kyohei Kin,Takao Yasuhara,Cesar V Borlongan et al.
Kyohei Kin et al.
As prevalence of depression continues to rise around the world, there remains a stagnation of available treatments as the affected population grows. The subset of treatment-resistant depression also is on the rise highlighting the need for ...
Wharton' jelly mesenchymal stromal cell therapy for ischemic brain injury [0.03%]
胎盘华通胶间充质基质细胞治疗缺血性脑损伤
Kuo-Jen Wu,Seong-Jin Yu,Chia-Wen Chiang et al.
Kuo-Jen Wu et al.
Increasing evidence have supported that Wharton's jelly mesenchymal stem cell (WJ-MSCs) have immunomodulatory and protective effects against several diseases including kidney, liver pathologies, and heart injury. Few in vitro studies have r...
White-matter repair: Interaction between oligodendrocytes and the neurovascular unit [0.03%]
少突胶质细胞与神经血管单元的相互作用促进白质修复
Gen Hamanaka,Ryo Ohtomo,Hajime Takase et al.
Gen Hamanaka et al.
There are currently no adequate treatments for white-matter injury, which often follows central nervous system maladies and their accompanying neurodegenerative processes. Indeed, the white matter is compromised by the deterioration of the ...
Combination of cell transplantation and glial cell line-derived neurotrophic factor-secreting encapsulated cells in Parkinson's disease [0.03%]
帕金森病细胞移植与胶质细胞系源性神经营养因子分泌的封装细胞联合治疗
Hans R Widmer
Hans R Widmer
A major limitation of cell transplantation for Parkinson's disease (PD) is the mediocre survival of the grafted cells. Facilitating graft survival may improve the functional outcomes of the transplanted cells. Here, we discuss our observati...
The final frontier: Transient microglia reduction after cosmic radiation exposure mitigates cognitive impairments and modulates phagocytic activity [0.03%]
最终前沿：宇宙射线暴露后的瞬态小胶质细胞减少可减轻认知障碍并调节吞噬作用
Susanna Rosi
Susanna Rosi
Microglia are the primary immune element within the brain, which are responsible for monitoring synapse function and neuron health. Exposure to cosmic radiation has the potential to cause long-term cognitive deficits in rodent models and th...
Combination therapy for ischemic stroke: Novel approaches to lengthen therapeutic window of tissue plasminogen activator [0.03%]
急性缺血性卒中静脉溶栓增效方案的研究进展及对策：延长组织型纤溶酶原激活物治疗时间窗的新思路
Talia Knecht,Cesar Borlongan,Ike Dela Peña
Talia Knecht
Tissue plasminogen activator (tPA) thrombolysis continues to be the gold standard therapy for ischemic stroke. Due to the time-limited treatment window, within 4.5 h of stroke onset, and a variety of potentially deadly complications related...
Eleonora Russo,Eleonora Napoli,Cesar V Borlongan
Eleonora Russo
Stroke is a debilitating disease that remains as a significant unmet need. Although our understanding of the disease pathology has advanced over the years, treatment options for stroke are limited. Recent studies have implicated the importa...