Effects of different degrees of insulin resistance on endothelial function in obese adults undergoing alternate day fasting [0.03%]
不同等级胰岛素抵抗对间歇性禁食肥胖成年人内皮功能的影响
Kristin K Hoddy,Surabhi Bhutani,Shane A Phillips et al.
Kristin K Hoddy et al.
BACKGROUND: Obesity can have deleterious effects on insulin sensitivity leading to endothelial dysfunction. Whether alternate day fasting (ADF) can ameliorate insulin sensitivity in a way that improves endothelial function remains unknown. ...
Reproduction regulates Drosophila nutrient intake through independent effects of egg production and sex peptide: Implications for aging [0.03%]
生殖通过独立的卵生成和性肽的作用调节果蝇的营养吸收：对衰老的影响
Elizabeth Bowman,Marc Tatar
Elizabeth Bowman
BACKGROUND: The ratio of protein to carbohydrate (P:C) consumed influences reproduction and lifespan, outcomes that are often maximized by different P:C intake. OBJECTIVE: Determine if reproduction in female Drosophila drives elevated P:C i...
Stage dependent nutritional regulation of transgenerational longevity [0.03%]
阶段性营养调节跨世代寿命上限的可能性及其机制研究
Ilianna G Roussou,Charalambos Savakis,Nektarios Tavernarakis et al.
Ilianna G Roussou et al.
BACKGROUND: Statistical analyses in human populations have associated limited food availability during development with increased longevity of next generations. In support, recent findings in Caenorhabditis elegans revealed nutritional effe...
Rachel A Brewer,Victoria K Gibbs,Daniel L Smith Jr
Rachel A Brewer
Advancing age is the greatest single risk factor for numerous chronic diseases. Thus, the ability to target the aging process can facilitate improved healthspan and potentially lifespan. Lack of adequate glucoregulatory control remains a re...
Emerging roles for histone deacetylases in age-related muscle atrophy [0.03%]
组蛋白去乙酰酶在与年龄有关的肌肉萎缩中发挥的作用
Michael E Walsh,Holly Van Remmen
Michael E Walsh
BACKGROUND: Skeletal muscle atrophy during aging, a process known as sarcopenia, is associated with muscle weakness, frailty, and the loss of independence in older adults. The mechanisms contributing to sarcopenia are not totally understood...
Human gut microbiota and healthy aging: Recent developments and future prospective [0.03%]
人类肠道微生物群与健康老龄化：最新研究进展和未来前景展望
Manish Kumar,Parizad Babaei,Boyang Ji et al.
Manish Kumar et al.
The human gut microbiota alters with the aging process. In the first 2-3 years of life, the gut microbiota varies extensively in composition and metabolic functions. After this period, the gut microbiota demonstrates adult-like more stable ...