Clinical Trials Corner [0.03%]
临床试验专栏
Leonie K Heilbronn
Leonie K Heilbronn
Effect of alternate day fasting on markers of bone metabolism: An exploratory analysis of a 6-month randomized controlled trial [0.03%]
隔日断食对骨代谢标志物的影响：一项为期6个月的随机对照试验的探索性分析
Adrienne Barnosky,Cynthia M Kroeger,John F Trepanowski et al.
Adrienne Barnosky et al.
Background: Alternate day fasting (ADF) is a novel diet therapy that reduces body weight, but its effect on bone health remains unknown. Objective: ...
The role of dietary patterns and exceptional parental longevity in healthy aging [0.03%]
饮食模式和异常父母长寿在健康老龄化中的作用
Sriram Gubbi,Nir Barzilai,Jill Crandall et al.
Sriram Gubbi et al.
Background: Individuals with exceptional longevity and their offspring manifest a lower prevalence of age-related diseases than families without longevity. However, the contribution of dietary habits to protection from di...
Short-term consumption of a plant protein diet does not improve glucose homeostasis of young C57BL/6J mice [0.03%]
短期食用植物蛋白饮食不会改善年轻C57BL/6J小鼠的葡萄糖稳态
Dudley W Lamming,Emma L Baar,Sebastian I Arriola Apelo et al.
Dudley W Lamming et al.
Recently, it has become apparent that dietary macronutrient composition has a profound impact on metabolism, health and even lifespan. Work from many laboratories now suggest that dietary protein quality - the precise amino acid composition...
Dominic Picetti,Stephen Foster,Amanda K Pangle et al.
Dominic Picetti et al.
Background: Inadequate hydration in the elderly is associated with increased morbidity and mortality. However, few studies have addressed the knowledge of elderly individuals regarding hydration in health and disease. Gap...
Stephen J Simpson,David G Le Couteur,David E James et al.
Stephen J Simpson et al.
Fundamental questions in nutrition include, "What constitutes a nutritionally balanced diet?", "What are the consequences of failing to achieve diet balance?", and "How does diet balance change across the lifecourse and with individual circ...
A central role for hypoxia-inducible factor (HIF)-2α in hepatic glucose homeostasis [0.03%]
缺氧诱导因子(HIF)-2α在肝脏葡萄糖稳态中起中心作用
Sadeesh K Ramakrishnan,Yatrik M Shah
Sadeesh K Ramakrishnan
Hepatic glucose production is regulated by hormonal and dietary factors. At fasting, 80% of glucose released into the circulation is derived from the liver, among which gluconeogenesis accounts for 55% and the rest by glycogenolysis. Studie...
Cathy Slack
Cathy Slack
Aberrant signal transduction downstream of the Ras GTPase has a well-established role in tumorigenesis. Mutations that result in hyperactivation of Ras are responsible for a third of all human cancers. Hence, small molecule inhibitors of th...
Clinical Trials Corner [0.03%]
临床试验角注板块
Leonie K Heilbronn
Leonie K Heilbronn
A randomized trial of the effects of the no-carrageenan diet on ulcerative colitis disease activity [0.03%]
无 carrageenan 饮食对溃疡性结肠炎疾病活动度的影响的随机试验
Sumit Bhattacharyya,Theresa Shumard,Hui Xie et al.
Sumit Bhattacharyya et al.
BACKGROUND: Carrageenan is a very common food additive in Western diets, but predictably causes inflammation in thousands of cell-based and animal experiments. OBJECTIVE: To assess the impact of carrageenan exposure on the interval to relap...