Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice [0.03%]
SIRT1在衰老小鼠中cue和context恐惧条件反射记忆中的表达是必需的
Devin Wahl,Rahul Gokarn,Sarah J Mitchell et al.
Devin Wahl et al.
Background: Sirtuin 1 (SIRT1) is a NAD+-dependent enzyme that has important roles in many biological processes involved in aging, including cell growth and repair, inflammation, and energy regulation. SIRT1 activity is mo...
Effects of timing of food intake and fat/carbohydrate ratio on insulin sensitivity and preconditioning against renal ischemia reperfusion injury by calorie restriction [0.03%]
摄食时间及脂质/碳水化合物比率对摄食限制诱导的胰岛素敏感性改善和肾脏缺血再灌注损伤预适应的影响
Justin S Reynolds,Wei Peng,Timothy Chu et al.
Justin S Reynolds et al.
Background: Dietary restriction (DR) improves lifespan, metabolic fitness and resilience in many organisms, but the role of dietary macronutrient composition and timing of food intake in specific benefits remains unclear....
Clinical Trials Corner [0.03%]
临床试验专栏
Leonie K Heilbronn
Leonie K Heilbronn
Effects of 8-hour time restricted feeding on body weight and metabolic disease risk factors in obese adults: A pilot study [0.03%]
每日8小时限时进食对肥胖成年人体重和代谢性疾病危险因素的影响：一项试点研究
Kelsey Gabel,Kristin K Hoddy,Nicole Haggerty et al.
Kelsey Gabel et al.
Background: Time restricted feeding decreases energy intake without calorie counting and may be a viable option for weight loss. However, the effect of this diet on body weight in obese subjects has never been examined. ...
Relationships between the inflammatory potential of the diet, aging and anthropometric measurements in a cross-sectional study in Pakistan [0.03%]
巴基斯坦一项横断面研究中关于饮食炎症潜力、年龄与人体测量数据之间关系的研究
Iftikhar Alam,Nitin Shivappa,James R Hebert et al.
Iftikhar Alam et al.
Background: Little is known about associations between dietary inflammation, age and anthropometric measurements. Objective: In this re...
Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults [0.03%]
姜黄素补充与健康中老年人的运动认知功能
Jessica R Santos-Parker,Kara L Lubieniecki,Matthew J Rossman et al.
Jessica R Santos-Parker et al.
Background: Recent studies suggest curcumin is a promising nutraceutical for improving important clinical and physiological markers of healthy aging, including motor and cognitive function. ...
Practice effects in nutrition intervention studies with repeated cognitive testing [0.03%]
营养干预研究中重复认知测试的练习效应
Lynne Bell,Daniel J Lamport,David T Field et al.
Lynne Bell et al.
Background: There is growing interest in the use of nutrition interventions to improve cognitive function. To determine intervention efficacy, repeated cognitive testing is often required. However, performance on tasks ca...
Ilja L Kruglikov,Philipp E Scherer
Ilja L Kruglikov
From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below th...
Devin Wahl,Michel Bernier,Stephen J Simpson et al.
Devin Wahl et al.
Resveratrol improves healthspan and lifespan in many organisms. Several different targets and mechanisms of action have been proposed to explain the beneficial effects of resveratrol on healthspan and longevity, including the activation of ...
Ravinder Nagpal,Rabina Mainali,Shokouh Ahmadi et al.
Ravinder Nagpal et al.
The development of human gut microbiota begins as soon as the neonate leaves the protective environment of the uterus (or maybe in-utero) and is exposed to innumerable microorganisms from the mother as well as the surrounding environment. C...