Stereodynamics of E/ Z isomerization in rotaxanes through mechanical shuttling and covalent bond rotation [0.03%]
轮烷通过机械穿梭和共价键旋转控制E/Z异构体立体动力学行为
Stefano Corra,Christiaan de Vet,Massimo Baroncini et al.
Stefano Corra et al.
The mechanical bond has opened a new world for structural and dynamic stereochemistry, which is still largely underexplored and whose significance for various applications is becoming increasingly evident. We demonstrate that designed rearr...
A General N-alkylation Platform via Copper Metallaphotoredox and Silyl Radical Activation of Alkyl Halides [0.03%]
通过铜金属光氧化还原和硅基自由基活化进行的烷基卤代物官能团化反应通用N-烷基化平台
Nathan W Dow,Albert Cabré,David W C MacMillan
Nathan W Dow
The catalytic union of amides, sulfonamides, anilines, imines or N-heterocycles with a broad spectrum of electronically and sterically diverse alkyl bromides has been achieved via a visible light-induced metallaphotoredox platform. The use ...
A Fluorinated Ionic Liquid-Based Activatable 19F MRI Platform Detects Biological Targets [0.03%]
一种基于氟化离子液体的活化型生物检测平台用于19F磁共振成像
Xianglong Zhu,Xiaoxue Tang,Hongyu Lin et al.
Xianglong Zhu et al.
19F magnetic resonance imaging (19F MRI) is a promising technique for in vivo molecular imaging and clinical diagnosis, benefiting from its negligible background and unlimited tissue penetration depth. However, the development of 19F probes...
Compatibility Score for Rational Electrophile Selection in Pd/NBE Cooperative Catalysis [0.03%]
钯/N-溴代丁二酰亚胺协同催化的兼容性分数用于合理亲电试剂的选择
Xiaotian Qi,Jianchun Wang,Zhe Dong et al.
Xiaotian Qi et al.
A mechanistically guided approach is developed to predict electrophile compatibility in the palladium/norbornene (Pd/NBE) cooperative catalysis for the ipso/ortho difunctionalization of aryl halides. A key challenge in these reactions is to...
Metalloradical activation of carbonyl azides for enantioselective radical aziridination [0.03%]
金属自由基活化胩重氮化合物实现映异选择性自由基环丙烷化反应
Xavier Riart-Ferrer,Peng Sang,Jingran Tao et al.
Xavier Riart-Ferrer et al.
Organic azides have been increasingly employed as nitrogen sources for catalytic olefine aziridination due to their ease of preparation and generation of benign N2 as the only byproduct. Among common organic azides, carbonyl azides have not...
Sang-Hyun Park,Seong-Hyun Park,Ethan N W Howe et al.
Sang-Hyun Park et al.
Recently, we showed that synthetic anion transporters DSC4P-1 and SA-3 had activity related to cancer cell death. They were found to increase intracellular chloride and sodium ion concentrations. They were also found to induce apoptosis (DS...
Mechanistic Origins of Regioselectivity in Cobalt-Catalyzed C(sp2)-H Borylation of Benzoate Esters and Arylboronate Esters [0.03%]
钴催化苯甲酸酯和芳基硼酸酯C(sp2)−H硼化的区域选择性的起源研究
Tyler P Pabst,Linda Quach,Kaitlyn T MacMillan et al.
Tyler P Pabst et al.
Synthetic and mechanistic investigations into the C(sp2)-H borylation of various electronically diverse arenes catalyzed by bis(phosphine)pyridine (iPrPNP) cobalt complexes are reported. Borylation of various benzoate esters and arylboronat...
Peter H Winegar,Oliver G Hayes,Janet R McMillan et al.
Peter H Winegar et al.
Designed DNA-DNA interactions are investigated for their ability to modulate protein packing within single crystals of mutant green fluorescent proteins (mGFPs) functionalized with a single DNA strand (mGFP-DNA). We probe the effects of DNA...
Anna Olerinyova,Adar Sonn-Segev,Joseph Gault et al.
Anna Olerinyova et al.
Integral membrane proteins (IMPs) are biologically highly significant but challenging to study because they require maintaining a cellular lipid-like environment. Here, we explore the application of mass photometry (MP) to IMPs and membrane...
Porphyrinoid Drug Conjugates [0.03%]
卟啉药物缀合物
Jonathan F Arambula,Jonathan L Sessler
Jonathan F Arambula
Drawing inspiration from nature today remains a time-honored means of discovering the therapies of tomorrow. Porphyrins, the so-called "pigments of life" have played a key role in this effort due to their diverse and unique properties. They...