Yifan Dai,Christian F Chamberlayne,Marco S Messina et al.
Yifan Dai et al.
Biomolecular condensates mediate diverse cellular processes. The density transition process of condensate formation results in selective partitioning of molecules, which define a distinct chemical environment within the condensates. However...
Data Science Enables the Development of a New Class of Chiral Phosphoric Acid Catalysts [0.03%]
数据科学助力开发新型手性磷酸催化剂
Jordan P Liles,Caroline Rouget-Virbel,Julie L H Wahlman et al.
Jordan P Liles et al.
The widespread success of BINOL-chiral phosphoric acids (CPAs) has led to the development of several high molecular weight, sterically encumbered variants. Herein, we disclose an alternative, minimalistic chiral phosphoric acid backbone inc...
Unified Total Synthesis of the Limonoid Alkaloids: Strategies for the De Novo Synthesis of Highly Substituted Pyridine Scaffolds [0.03%]
Limidine类生物碱的统一全合成：高度取代吡啶骨架从头合成策略
Alexander W Schuppe,Yannan Liu,Elsie Gonzalez-Hurtado et al.
Alexander W Schuppe et al.
Highly substituted pyridine scaffolds are found in many biologically active natural products and therapeutics. Accordingly, numerous complementary de novo approaches to obtain differentially substituted pyridines have been disclosed. This a...
Pillar[6]MaxQ: A Potent Supramolecular Host for In Vivo Sequestration of Methamphetamine and Fentanyl [0.03%]
柱芳烃Pillar[6]MaxQ：一种强大的超分子主体，用于体内捕获冰毒和芬太尼
Adam T Brockett,Weijian Xue,David King et al.
Adam T Brockett et al.
Pillar[6]MaxQ (P6AS) functions as an in vivo sequestration agent for methamphetamine and fentanyl. We use 1H NMR, isothermal titration calorimetry, and molecular modelling to deduce the geometry and strength of the P6AS•drug complexes. P6A...
A chemical strategy to study transient states in substrate ubiquitylation by cryo-EM [0.03%]
一种化学策略通过冷冻电镜研究底物泛素化的瞬态状态
Qi Hu,Maria Victoria Botuyan,Georges Mer
Qi Hu
The characterization of short-lived intermediate states along the path of a ubiquitylation reaction remains a major challenge. In this issue of Chem, Ai et al. present a chemical trapping method for probing transient intermediates in substr...
Charge-controlled Pd catalysis enables the meta-C-H activation and olefination of arenes [0.03%]
电荷控制的钯催化体系能够使芳烃均相C-H活化及烯基化反应发生
Arup Mondal,Marina Díaz-Ruiz,Fritz Deufel et al.
Arup Mondal et al.
The regioselective C-H activation of arenes remains one of the most promising techniques for accessing highly important functionalized motifs. Such functionalizations can generally be achieved through directed and non-directed processes. Th...
Zining Li,Baofu Xu,Volga Kojasoy et al.
Zining Li et al.
Terpenoids are the largest family of natural products, but prokaryotes are vastly underrepresented in this chemical space. However, genomics supports vast untapped biosynthetic potential for terpenoids in bacteria. We discovered the first t...
11C, 12C and 13C-Cyanation of Electron-Rich Arenes via Organic Photoredox Catalysis [0.03%]
电子丰富的芳烃的11C，12C和13C-CN化反应通过有机光氧化还原催化实现
Xuedan Wu,Wei Chen,Natalie Holmberg-Douglas et al.
Xuedan Wu et al.
As a non-invasive imaging technology, positron emission tomography (PET) plays a crucial role in personalized medicine, including early diagnosis, patient screening, and treatment monitoring. The advancement of PET research depends on the d...
General and Selective Metal-Free Radical α-C-H Borylation of Aliphatic Amines [0.03%]
脂肪胺的通用性和选择性的金属-free自由基α-C-H硼化反应
Sumon Sarkar,Sidhant Wagulde,Xiangqing Jia et al.
Sumon Sarkar et al.
Despite recent developments, selective C(sp3)-H borylation of feedstock amines remains a formidable challenge. Herein, we have developed a general, mild, and photoinduced transition metal- and strong base-free method for α-C(sp3)-H borylat...
Modular Nucleic Acid Scaffolds for Synthesizing Monodisperse and Sequence-Encoded Antibody Oligomers [0.03%]
用于合成单分散和序列编码的抗体寡聚体的模块化核酸支架
Peter H Winegar,C Adrian Figg,Michelle H Teplensky et al.
Peter H Winegar et al.
Synthesizing protein oligomers that contain exact numbers of multiple different proteins in defined architectures is challenging. DNA-DNA interactions can be used to program protein assembly into oligomers; however, existing methods require...