Revisiting PFA-mediated tissue fixation chemistry: FixEL enables trapping of small molecules in the brain to visualize their distribution changes [0.03%]
重新审视PFA介导的组织固定化学：FixEL使大脑中小分子的捕获成为可能以可视化其分布变化
Hiroshi Nonaka,Takeharu Mino,Seiji Sakamoto et al.
Hiroshi Nonaka et al.
Various small molecules have been used as functional probes for tissue imaging in medical diagnosis and pharmaceutical drugs for disease treatment. The spatial distribution, target selectivity, and diffusion/excretion kinetics of small mole...
Jiaqi Guo,Shane T Rich-New,Chen Liu et al.
Jiaqi Guo et al.
The understanding on how short peptide assemblies transit from disorder to order remains limited due to the lack of atomistic structures. Here we report cryo-EM structure of the nanofibers short intrinsically disordered peptides (IDPs). Upo...
Alan K Wortman,Corey R J Stephenson
Alan K Wortman
Recently, organic synthesis has seen a renaissance in radical chemistry due to the accessibility of mild methods for radical generation using visible light. While renewed interest in synthetic radical chemistry has been driven by the advent...
Retraction Notice to: Nanoscale Metal-Organic Framework Mediates Radical Therapy to Enhance Cancer Immunotherapy [0.03%]
撤稿通知：纳米金属有机骨架介导的自由基疗法可增强癌症免疫治疗
Kaiyuan Ni,Theint Aung,Shuyi Li et al.
Kaiyuan Ni et al.
[This retracts the article PMC6681452.].
Retraction of Publication
Chem. 2023 Mar 9;9(3):755. DOI:10.1016/j.chempr.2023.02.003 2023
Vivian Zhang,Joseph V Accardo,Ilia Kevlishvili et al.
Vivian Zhang et al.
Dithioalkylidenes are a newly-developed class of conjugate acceptors that undergo thiol exchange via an associative mechanism, enabling decoupling of key material properties for sustainability, biomedical, and sensing applications. Here, we...
Recent updates and future perspectives in aziridine synthesis and reactivity [0.03%]
氮杂环丙烷合成与反应的最新进展和未来展望
Hillary J Dequina,Corey L Jones,Jennifer M Schomaker
Hillary J Dequina
In this review, selected recent advances in the preparation and reactivity of aziridines using modern synthetic approaches are highlighted, while comparing these new strategies with more classical approaches. This critical analysis is desig...
Grace A Lutovsky,Samuel N Gockel,Mark W Bundesmann et al.
Grace A Lutovsky et al.
Carboxylic acids are valuable building blocks for pharmaceutical discovery because of their chemical stability, commercial availability, and structural diversity. Decarboxylative coupling reactions enable versatile functionalization of thes...
Christian S Diercks,David A Dik,Peter G Schultz
Christian S Diercks
The maturation of chemical synthesis during the 20th century has elevated the discipline from a largely empirical into a rational science. This ability to purposefully craft matter at the molecular level has put chemists in a privileged pos...
Generative design of de novo proteins based on secondary structure constraints using an attention-based diffusion model [0.03%]
基于二次结构约束的注意力扩散模型的新蛋白质生成设计
Bo Ni,David L Kaplan,Markus J Buehler
Bo Ni
We report two generative deep learning models that predict amino acid sequences and 3D protein structures based on secondary structure design objectives via either overall content or per-residue structure. Both models are robust regarding i...
Visible-light-induced coupling of carboxylic acids with alcohols/amines via a phosphorous linchpin strategy [0.03%]
可见光促进磷键合催化羧酸与醇/胺的偶联反应研究
Qiupeng Peng,Achyut Ranjan Gogoi,Ángel Rentería-Gómez et al.
Qiupeng Peng et al.
The combination of activated carboxylic acids and alcohols/amines to access esters and amides, respectively, is a cornerstone of organic chemistry and has been well developed over the past century. These dehydrations are extensively used in...