Three-component enantioselective alkenylation of organophosphonates via nickel metallaphotoredox catalysis [0.03%]
镍金属光氧化还原催化的有机磷酯的三组分对映选择性烯基化反应
Xiaofang Li,Mingbin Yuan,Fan Chen et al.
Xiaofang Li et al.
The development of efficient catalytic multicomponent reactions (MCRs) is highly sought-after in chemical synthesis. However, catalytic asymmetric MCRs, particularly involving radical species, remain largely underdeveloped due to the except...
Terpenoid-Based High-Performance Polyester with Tacticity-Independent Crystallinity and Chemical Circularity [0.03%]
基于萜类的高性能聚酯，具有立构独立结晶性和化学循环性
Zhitao Hu,Simone N Bernsten,Changxia Shi et al.
Zhitao Hu et al.
The development of chemically circular, bio-based polymers is an urgently needed solution to combat the plastic waste crisis. However, the most prominent, commercially implemented bio-based aliphatic polyester, poly(lactic acid) (PLA), is b...
Florian Hubrich,Sanath K Kandy,Clara Chepkirui et al.
Florian Hubrich et al.
Isoprenoid modifications of proteins and peptides serve fundamental biological functions and are of therapeutic interest. While C15 (farnesyl) and C20 (geranylgeranyl) moieties are prevalent among proteins, known ribosomal peptide prenylati...
Spin-Coupled Electron Densities of Iron-Sulfur Cluster Imaged by In Situ Serial Laue Diffraction [0.03%]
原位拉莫尔衍射成像铁硫簇自旋耦合电子密度分布
Zhong Ren,Fan Zhang,Weijia Kang et al.
Zhong Ren et al.
Iron-sulfur clusters are inorganic cofactors found in many proteins involved in fundamental biological processes. The prokaryotic DNA repair photolyase PhrB carries a four-iron-four-sulfur cluster ([4Fe4S]) in addition to the catalytic flav...
Radical Chlorination of Non-Resonant Heterobenzylic C-H Bonds and High-Throughput Diversification of Heterocycles [0.03%]
非共振杂芳基烯丙位C-H键的氯化反应及含杂环分子的高通量化合物多样性输出
Dung L Golden,Kaitlyn M Flynn,Santeri Aikonen et al.
Dung L Golden et al.
Site-selective functionalization of the heterobenzylic C(sp3)-H bonds of pyridines and related heteroaromatic compounds presents challenges associated with the basic nitrogen atom and the variable reactivity among different positions on the...
Cyclopropanation of unactivated alkenes with non-stabilized iron carbenes [0.03%]
非稳定的铁亚 carbene与非活化的烯烃环丙烷化反应
Bethany M DeMuynck,Lumin Zhang,Emma K Ralph et al.
Bethany M DeMuynck et al.
Cyclopropanes are ubiquitous in medicines, yet robust synthetic access to a wide range of sterically and electronically diverse analogs remains a challenge. To address the synthetic limitations of the most direct strategy, (2+1) cycloadditi...
Rapid, Multiplexed, and Enzyme-Free Nucleic Acid Detection Using Programmable Aptamer-Based RNA Switches [0.03%]
一种使用可编程的基于适配体的RNA开关进行快速、多重和无酶核酸检测的方法
Zhaoqing Yan,Amit Eshed,Anli A Tang et al.
Zhaoqing Yan et al.
Rapid, simple, and low-cost diagnostic technologies are crucial tools for combatting infectious disease. We describe a class of aptamer-based RNA switches or aptaswitches that recognize target nucleic acid molecules and initiate folding of ...
Correction: Poison to promise: The resurgence of organophosphorus fluoride chemistry [0.03%]
关于“从毒药到承诺——有机磷氟化学的复兴”的更正通知
William P Chappell,Natalie Schur,James A Vogel et al.
William P Chappell et al.
[This corrects the article PMC11212144.].
Published Erratum
Chem. 2024 Jul 11;10(7):2324-2327. DOI:10.1016/j.chempr.2024.06.011 2024
Juan A Valdez-Moreira,Duleeka C Wannipurage,Maren Pink et al.
Juan A Valdez-Moreira et al.
Iron sulfur clusters are critical to a plethora of biological processes; however, little is known about the elementary unit of these clusters, namely the [Fe=S]n+ fragment. Here, we report the synthesis and characterization of a terminal ir...
Data-science-guided calibration curve prediction of an MLCT-based ee determination assay for chiral amines [0.03%]
基于MLCT的拆分胺类手性化合物ee值测定法的数据科学校正曲线预测模型
James R Howard,Julia R Shuluk,Arya Bhakare et al.
James R Howard et al.
Circular dichroism (CD) based enantiomeric excess (ee) determination assays are optical alternatives to chromatographic ee determination in high-throughput screening (HTS) applications. However, the implementation of these assays requires c...