Shaping Molecular Landscapes: Recent Advances, Opportunities, and Challenges in Dearomatization [0.03%]
分子景观的塑造：脱芳香化领域的最新进展、机遇与挑战
Christopher J Huck,David Sarlah
Christopher J Huck
Dearomatization is a fundamental chemical transformation, and it underlies some of the most efficient tactics for generating three-dimensional complexity from basic two-dimensional precursors. The dearomative toolbox, once restricted to onl...
Learning to Make Chemical Predictions: the Interplay of Feature Representation, Data, and Machine Learning Methods [0.03%]
化学预测的机器学习：特征表示、数据和算法之间的相互作用
Mojtaba Haghighatlari,Jie Li,Farnaz Heidar-Zadeh et al.
Mojtaba Haghighatlari et al.
Recently supervised machine learning has been ascending in providing new predictive approaches for chemical, biological and materials sciences applications. In this Perspective we focus on the interplay of machine learning method with the c...
Encapsulated Nanodroplet Crystallization of Organic-Soluble Small Molecules [0.03%]
有机可溶性小分子的封装型纳微滴结晶法
Andrew R Tyler,Ronnie Ragbirsingh,Charles J McMonagle et al.
Andrew R Tyler et al.
Single-crystal X-ray diffraction analysis (SCXRD) constitutes a universal approach for the elucidation of molecular structure and the study of crystalline forms. However, the discovery of viable crystallization conditions remains both exper...
Regio- and Stereoselective Synthesis of 1,2-Dihaloalkenes Using In-Situ-Generated ICl, IBr, BrCl, I2, and Br2 [0.03%]
就地生成的ICl、IBr、BrCl、I₂和Br₂参与的1,2-二卤代烯烃的区域及立体选择性合成
Xiaojun Zeng,Shiwen Liu,Yuhao Yang et al.
Xiaojun Zeng et al.
We describe a catalyst-free 1,2-trans-dihalogenation of alkynes with an unprecedented substrate scope and exclusive regio- and stereoselectivity. This versatile dihalogenation system-a combination of NX1S electrophile and alkali metal halid...
Developments in Photoredox/Nickel Dual-Catalyzed 1,2-Difunctionalizations [0.03%]
光氧化还原/镍双催化的1,2-双官能化反应研究进展
Shorouk O Badir,Gary A Molander
Shorouk O Badir
Progress in Ni/photoredox dual catalysis has enabled the construction of C(sp3)-hybridized centers under extremely mild reaction conditions in the presence of diverse functional groups. These strategies, however, are mainly restricted to th...
Alexander Dömling,Li Gao
Alexander Dömling
SARS-CoV-2 (previously 2019-nCoV or Wuhan coronavirus) caused an unprecedented fast-spreading worldwide pandemic. Although currently with a rather low mortality rate, the virus spread rapidly over the world using the modern world's traffic ...
A General Approach to Stereospecific Cross-Coupling Reactions of Nitrogen-Containing Stereocenters [0.03%]
一种氮手性中心的立体专一性交叉偶联反应的通用方法
Xinghua Ma,Haoran Zhao,Meruyert Binayeva et al.
Xinghua Ma et al.
A novel strategy employing cyclohexyl spectator ligands in Stille cross-coupling reactions has been developed as a general solution to the long-standing challenge of conducting stereospecific cross-coupling reactions at nitrogen-containing ...
Erratum: Regio- and Stereoselective Rhodium(II)-Catalyzed C-H Functionalization of Cyclobutanes [0.03%]
erratum：环丁烷的区域和立体选择性的铑(ii)催化c-h功能化
Zachary J Garlets,Benjamin D Wertz,Wenbin Liu et al.
Zachary J Garlets et al.
[This corrects the article PMC7233328.].
Published Erratum
Chem. 2020 Feb 13;6(2):538. DOI:10.1016/j.chempr.2020.01.007 2020
Regio- and Stereoselective Rhodium(II)-Catalyzed C-H Functionalization of Cyclobutanes [0.03%]
环丁烷的区域和立体选择性Rh(II)催化C-H官能团化反应
Zachary J Garlets,Benjamin D Wertz,Wenbin Liu et al.
Zachary J Garlets et al.
Recent developments in controlled C-H functionalization transformations continue to inspire new retrosynthetic disconnections. One tactic in C-H functionalization is the intermolecular C-H insertion reaction of rhodium bound carbenes. These...
Synthesis of a Mechanically Planar Chiral Rotaxane Ligand for Enantioselective Catalysis [0.03%]
用于手性催化的机械平面手性轮烷配体的合成
Andrew W Heard,Stephen M Goldup
Andrew W Heard
Rotaxanes are interlocked molecules in which a molecular ring is trapped on a dumbbell-shaped axle because of its inability to escape over the bulky end groups, resulting in a so-called mechanical bond. Interlocked molecules have mainly bee...