Reengineering a Reversible Covalent-Bonding Assembly to Optically Detect ee in β-Chiral Primary Alcohols [0.03%]
通过光学方法检测β-手性伯醇ee值的可逆共价键合成的工程化改造
Matthew B Minus,Aaron L Featherston,Sooyun Choi et al.
Matthew B Minus et al.
The use of parallel synthesis protocols for asymmetric reaction discovery has increased the need for new methods to rapidly determine enantiomeric excess (ee) values. Most chirality sensing is performed on stereocenters that are α (i.e., p...
Creation of Bacterial cells with 5-Hydroxytryptophan as a 21st Amino Acid Building Block [0.03%]
以5-羟色氨酸为第21种氨基酸构建模块的细菌细胞的创建
Yuda Chen,Juan Tang,Lushun Wang et al.
Yuda Chen et al.
While most organisms utilize 20 canonical amino acid building blocks for protein synthesis, adding additional candidates to the amino acid repertoire can greatly facilitate the investigation and manipulation of protein structures and functi...
Indoor Surface Chemistry: Developing a Molecular Picture of Reactions on Indoor Interfaces [0.03%]
室内表面化学：在室内界面上构建反应的分子图像
Andrew P Ault,Vicki H Grassian,Nicola Carslaw et al.
Andrew P Ault et al.
Chemical reactions on indoor surfaces play an important role in air quality in indoor environments, where humans spend 90% of their time. We focus on the challenges of understanding the complex chemistry that takes place on indoor surfaces ...
Mitochondrial relocation of a common synthetic antibiotic: A non-genotoxic approach to cancer therapy [0.03%]
常见合成抗生素的线粒体重新定位：癌症治疗的非遗传毒性方法
Kyoung Sunwoo,Miae Won,Kyung-Phil Ko et al.
Kyoung Sunwoo et al.
Tumor recurrence as a result of therapy-induced nuclear DNA lesions is a major issue in cancer treatment. Currently, only a few examples of potentially non-genotoxic drugs have been reported. Mitochondrial re-localization of ciprofloxacin, ...
Eszter Boros,Paul J Dyson,Gilles Gasser
Eszter Boros
Metal-based drugs and imaging agents are extensively used in the clinic for the treatment and diagnosis of cancers and a wide range of other diseases. The current clinical arsenal of compounds operate via a limited number of mechanisms, whe...
Surface Chemistry Can Unlock Drivers of Surface Stability of SARS-CoV-2 in a Variety of Environmental Conditions [0.03%]
表面化学可以在各种环境条件下解锁SARS-CoV-2表面稳定性的驱动因素
Edris Joonaki,Aliakbar Hassanpouryouzband,Caryn L Heldt et al.
Edris Joonaki et al.
The surface stability and resulting transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), specifically in indoor environments, have been identified as a potential pandemic challenge requiring investigation. This nove...
Molecular Design of Stable Sulfamide- and Sulfonamide-based Electrolytes for Aprotic Li-O2 Batteries [0.03%]
用于无溶剂Li-O2电池的稳定磺胺和磺酰胺类电解质的分子设计
Shuting Feng,Mingjun Huang,Jessica R Lamb et al.
Shuting Feng et al.
Electrolyte instability is one of the most challenging impediments to enabling Lithium-Oxygen (Li-O2) batteries for practical use. The use of physical organic chemistry principles to rationally design new molecular components may enable the...
Discovery of a Small Molecule Drug Candidate for Selective NKCC1 Inhibition in Brain Disorders [0.03%]
用于脑部疾病中选择性NKCC1抑制的小分子药物候选物的发现
Annalisa Savardi,Marco Borgogno,Roberto Narducci et al.
Annalisa Savardi et al.
Aberrant expression ratio of Cl- transporters, NKCC1 and KCC2, is implicated in several brain conditions. NKCC1 inhibition by the FDA-approved diuretic drug, bumetanide, rescues core symptoms in rodent models and/or clinical trials with pat...
Direct Observation and Analysis of the Halo-Amino-Nitro Alkane Functional Group [0.03%]
halo-氨基-硝基烷功能群的直接观察与分析
Michael S Crocker,Hayden Foy,Kazuyuki Tokumaru et al.
Michael S Crocker et al.
Conventional amide synthesis is a mainstay in discipline-spanning applications, and it is a reaction type that historically developed as a singular paradigm when considering the carbon-nitrogen bond-forming step. Umpolung amide synthesis (U...
Size-selective Catalytic Polymer Acylation with a Molecular Tetrahedron [0.03%]
分子四面体对尺寸选择性催化聚合物酰化反应
Mona Sharafi,Kyle T McKay,Monika Ivancic et al.
Mona Sharafi et al.
Selective catalysis at the molecular level represents a cornerstone of chemical synthesis. However, it still remains an open question how to elevate tunable catalysis to larger length scales to functionalize whole polymer chains in a select...