Clinical potential of SAG-524: A novel HBV RNA destabilizer with a unique mechanism of action [0.03%]
SAG-524的临床潜力：具有独特作用机制的新HBV RNA不稳定剂
Yasuhito Tanaka
Yasuhito Tanaka
SAG-524 is a novel, oral HBV RNA destabilizer developed to address the limitations of treatment with nucleos(t)ide analogues (NAs), which are effective against HBV DNA but show limited efficacy in reducing hepatitis B surface antigen (HBsAg...
Current global applications of HBcrAg assays in the management of chronic hepatitis B [0.03%]
HBcrAg检测在慢性乙型肝炎管理中的当前全球应用
Takako Inoue,Yasuhito Tanaka
Takako Inoue
Hepatitis B core-related antigen (HBcrAg) is a vital marker for monitoring chronic hepatitis B (CHB) as it correlates with hepatitis B (HBV) DNA and covalently closed circular DNA (cccDNA). The iTACT-HBcrAg assay, approved in Japan, provide...
Analysis of the toxic and lethal doses of one over-the-counter drug product in humans and the ingredients that may be abused: Building a drug database to prevent drug overdoses [0.03%]
一种非处方药产品在人体内的毒性和致死剂量分析以及可能被滥用的成分：建立数据库以防止药物过量使用的模型
Kazuki Nagashima,Rin Tanaka,Miyu Nakahara et al.
Kazuki Nagashima et al.
Pharmacists who provide medication to patients immediately before they overdose should intervene appropriately; however, little information exists on the types and amounts of over-the-counter (OTC) drugs that are dangerous. This study inves...
Post-COVID-19 era trends in foreigners undergoing a complete medical examination in Japan: A single-center analysis of inbound medical care [0.03%]
后COVD-19时代在日本进行全面体检的外国人趋势：单中心分析入境医疗的趋势
Jun Lu,Sachiko Kubo,Makiko Hashimoto et al.
Jun Lu et al.
In the post-COVID-19 era, inbound medical care in Japan adapted to the growing demand for high-quality and precise healthcare. One form of this care is a complete medical examination, which has gained significant popularity among foreign re...
Higher FIB-4 index at baseline predicts development of liver cancer in a community-based cohort with viral hepatitis [0.03%]
基线较高的FIB-4指数可预测病毒性肝炎社区人群肝癌的发生发展
Makiko Kimura,Tomoki Nishikawa,Tetsuro Shimakami et al.
Makiko Kimura et al.
Hepatitis B and C (HBV and HCV) testing has been performed in Japan since 2002 and is subsidized by central and prefectural governments. A follow-up program for HBV- or HCV-infected persons was started at that time in Ishikawa Prefecture. T...
Suicide attempt and self-harm among hospitalized children in Japan: A nationwide inpatient database study [0.03%]
日本住院儿童自杀企图与自伤的全国性入院数据库研究
Sachiko Kita,Kojiro Morita,Hideaki Watanabe et al.
Sachiko Kita et al.
This study aims to delineate the characteristics and clinical trajectories of suicide attempts and self-harm, and its gender and age differences among children. This nationwide retrospective cross-sectional study utilized data extracted fro...
Increase in the number of female doctors and the challenges that Japan's medical system must face [0.03%]
日本女医生人数增加及其医疗系统面临的挑战
Shotaro Kinoshita,Taishiro Kishimoto
Shotaro Kinoshita
Japan has seen an increase in female physicians recently, yet it still lags behind other Organization for Economic Cooperation and Development (OECD) countries. A major barrier has been the historical discrimination against women in medical...
Analysis of recent changes in treatment options for patients with hepatocellular carcinoma using data from a highly comprehensive Japanese national database: Impact of advances in systemic therapy and minimally invasive surgery [0.03%]
利用日本大型国家数据库数据对肝细胞癌患者治疗手段变化的分析：系统性治疗及微创手术进展的影响
Takashi Kokudo,Yasuhide Yamada,Takehiro Sugiyama et al.
Takashi Kokudo et al.
In 2011, the Ministry of Health, Labour and Welfare started providing data from the National Database of Health Insurance Claims and Specific Health Checkups of Japan (NDB) for research purposes. The NDB is an exhaustive and valuable databa...
Patient-specific brain fluorodeoxyglucose positron emission tomography can detect the first effects of combination antiretroviral therapy in patient with HIV infection [0.03%]
患者特异性的脑氟脱氧葡萄糖正电子发射断层扫描能够检测到HIV感染的患者使用抗逆转录病毒联合药物治疗后产生的第一批效应
Miyako M Chikanishi,Junko Tanuma,Kenji Ishii et al.
Miyako M Chikanishi et al.
Patient-specific brain fluorodeoxyglucose-positron emission tomography (FDG PET) can detect areas with abnormal FDG uptake in patients with human immunodeficiency virus (HIV) before and after combination antiretroviral therapy (cART). There...
Adverse reactions to mRNA COVID-19 vaccine in people with allergies in Japan [0.03%]
日本过敏人群接种新冠mRNA疫苗的不良反应
Naoko Shoji,Suminobu Ito,Shuko Nojiri et al.
Naoko Shoji et al.
mRNA vaccines emerged as a new therapeutic modality during the COVID-19 pandemic. Individuals with allergies often experience anxiety about potential adverse reactions to these vaccines. This study aims to elucidate the relationship between...