Molecular crosstalk in SP7-mediated osteogenesis: Regulatory mechanisms and therapeutic potential [0.03%]
SP7介导的骨发生的分子交叉谈话：调控机制和治疗潜力
Jun Lang,Vivek Kumar Morya,Mi-Kyung Kwak et al.
Jun Lang et al.
SP7, also known as Osterix, is a zinc finger-containing transcription factor, plays a crucial role in osteoblast differentiation and bone formation. This review examines the molecular mechanisms underlying SP7's regulatory functions, highli...
Minji Im,Sung Yoon Cho
Minji Im
Hypophosphatasia (HPP) is a rare inherited metabolic bone disorder caused by loss-of-function mutations in the ALPL gene, leading to deficient activity of tissue-nonspecific alkaline phosphatase (TNSALP). HPP is diagnosed based on a combina...
Systematic druggable genome-wide Mendelian randomization identifies therapeutic targets for osteoporosis [0.03%]
系统门德尔随机化 genomewide 关联分析鉴定脆性骨折潜在药物靶点
Chiyun Sun,Ruikang Liu,Jiaming Hu et al.
Chiyun Sun et al.
Objectives: The aim of this study was to find potential drug targets of osteoporosis (OP) through systematic druggable genome-wide Mendelian randomization (MR) analysis. ...
Comparing mortality rates, risk, and trends of hip fracture and common cancers in Hong Kong, 2010-2020: A population-based study [0.03%]
2010至2020年香港股骨骨折与常见癌症的死亡率、风险和趋势的基于人群的研究
Xiaowen Zhang,Chor-Wing Sing,Philip Cm Au et al.
Xiaowen Zhang et al.
Objectives: Hip fracture is a global public concern exhibiting high mortality rates but often underrecognized. We compared the mortality rates, risk, and secular trend of hip fractures with common cancers in females and m...
Two novel rare variants in the PTH gene found in patients with hypoparathyroidism [0.03%]
在特发性低钙血症患者中发现的两个新型罕见PTH基因变异
Yue Jiang,An Song,Jiajia Wang et al.
Yue Jiang et al.
Objectives: Hypoparathyroidism (HP) is a rare endocrine disorder caused by parathyroid hormone (PTH) deficiency. The PTH is a candidate gene for familial isolated hypoparathyroidism (FIH). This study aimed to investigate ...
Disorders of bone and mineral metabolism in pregnancy and lactation: A case based clinical review [0.03%]
妊娠和哺乳期骨代谢紊乱：基于病例的临床综述
Manju Chandran,Sarah Ying Tse Tan
Manju Chandran
Bone and mineral metabolism in the human body undergoes significant adaptations during pregnancy and lactation to meet the physiological demands of both the mother and fetus. The growing fetus requires approximately 30 g of calcium, with 80...
A predictive nomogram for selective screening of asymptomatic vertebral fractures: The Vietnam Osteoporosis Study [0.03%]
无症状椎体骨折选择性筛查的预测列线图：越南骨质疏松症研究
Hoa T Nguyen,Bao T Nguyen,An V Tran et al.
Hoa T Nguyen et al.
Objectives: Vertebral fractures are associated with disability and mortality, but most vertebral fractures are asymptomatic. The present study aimed to determine the incidence of and develop a predictive nomogram for asym...
Ji-Young Seo
Ji-Young Seo