Recent advances of integrated microfluidic suspension cell culture system [0.03%]
集成式微流体悬浮细胞培养系统的最新进展
Yi Jing Kerk,Aysha Jameel,Xin-Hui Xing et al.
Yi Jing Kerk et al.
Microfluidic devices with superior microscale fluid manipulation ability and large integration flexibility offer great advantages of high throughput, parallelisation and multifunctional automation. Such features have been extensively utilis...
Dynamical model fitting to a synthetic positive feedback circuit in E. coli [0.03%]
大肠杆菌合成正反馈电路的动力学模型拟合
Jure Tica,Tong Zhu,Mark Isalan
Jure Tica
Applying the principles of engineering to Synthetic Biology relies on the development of robust and modular genetic components, as well as underlying quantitative dynamical models that closely predict their behaviour. This study looks at a ...
Hydrogen oxidising bacteria for production of single-cell protein and other food and feed ingredients [0.03%]
用于生产单细胞蛋白及其他食品和饲料原料的产氢细菌氧化作用
Bart Pander,Zahara Mortimer,Craig Woods et al.
Bart Pander et al.
Using hydrogen oxidising bacteria to produce protein and other food and feed ingredients is a form of industrial biotechnology that is gaining traction. The technology fixes carbon dioxide into products without the light requirements of agr...
Mechanistic modelling of tyrosine recombination reveals key parameters determining the performance of a CAR T cell switching circuit [0.03%]
酪氨酸重组的机制模型揭示了CAR-T细胞切换电路性能的关键参数
Jack E Bowyer,Deboki Chakravarti,Wilson W Wong et al.
Jack E Bowyer et al.
Inducible genetic switches based on tyrosine recombinase-based DNA excision are a promising platform for the regulation and control of chimeric antigen receptor (CAR) T cell activity in cancer immunotherapy. These switches exploit the incre...
Towards engineering and production of artificial spider silk using tools of synthetic biology [0.03%]
合成生物学技术在人工蜘蛛丝工程和生产中的应用
Hashwardhan Poddar,Rainer Breitling,Eriko Takano
Hashwardhan Poddar
Spider silk is one of the strongest biomaterials available in nature. Its mechanical properties make it a good candidate for applications in various fields ranging from protective armour to bandages for wound dressing to coatings for medica...
Machine learning-driven protein engineering: a case study in computational drug discovery [0.03%]
基于机器学习的蛋白质工程：计算药物发现中的一个案例研究
Harry F Rickerby,Katya Putintseva,Christopher Cozens
Harry F Rickerby
Research and development in drug discovery will need to find significant efficiency gains if the industry is to continue generating novel drugs. There is great expectation for machine learning (ML) to provide this boost in R&D productivity,...
Natalie Curach
Natalie Curach
In Australia, synthetic biology has taken a gradual and rational passage of growth from a collective of discrete practitioners and projects to capacity building initiatives. These initiatives fall under the National Innovation and Science A...
Case Reports
Engineering biology. 2021 Jun 13;5(2):43-47. DOI:10.1049/enb2.12009 2021
Ruoxuan Sun,Sierin Lim
Ruoxuan Sun
Proteins naturally self-assemble to function. Protein cages result from the self-assembly of multiple protein subunits that interact to form hollow symmetrical structures with functions that range from cargo storage to catalysis. Driven by ...
Defense Advanced Research Projects Agency: Comment on 'Engineering biology and the grand challenges: Do we need a new R&D&I model?' [0.03%]
评论：“工程生物学与重大挑战——我们需要新的研究、开发和创新模式吗？” DARPA 的回应
Ilya Klabukov,Olga Krasilnikova
Ilya Klabukov
This comment paper refers to the article published by Gauvreau et al. in Engineering Biology in 2018. Gauvreau et al. discussed various civilian models in the private and public sectors that could boost R&D plus Innovation (R&D&I) progress ...
Reducing metabolic burden in the PACEmid evolver system by remastering high-copy phagemid vectors [0.03%]
通过重塑高拷贝噬菌体辅助质粒载体减轻PACEmid进化系统中的代谢负担
Beth India Davenport,Jure Tica,Mark Isalan
Beth India Davenport
Orthogonal or non-cross-reacting transcription factors are used in synthetic biology as components of genetic circuits. Brödel et al. (2016) engineered 12 such cIλ transcription factor variants using a directed evolution 'PACEmid' system....